Acid-Sensing Ion Channel (ASIC)
Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat Acid-Sensing Ion Channel 1a
... Abstract Acid-sensing ion channels (ASICs) are proton-gated cationic channels involved in pain and other processes, underscoring the potential therapeutic value of specific inhibitors such as the ...
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Acid-sensing ion channels in postoperative pain.
... ASIC3-containing channels are particularly well suited to de- tect local changes in pH associated with postoperative pain and to contribute to nociceptor sensitization: (1) they exhibit the high- est sensitivity to ...
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Acid-Sensing Ion Channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis
... lined spinal BDNF-induced pain hypersensitivity through a mechanism of spinal central sensitisation involving the PI3-kinase/Akt pathway. They established that activation of the PI3-kinase/Akt pathway by BDNF regulates ...
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en fr Involvement of nerve growth factor (NGF) and acid-sensing ion channels (ASIC) in colonic hypersensitivity induced by butyrate in the rat Étude de l'implication du Nerve Growth Factor et des Acid-Sensing Ion Channels dans l'hypersensibilité colique induite par le butyrate chez le rat
... ASIC1A channel contributes to ion currents evoked by painful stimulations, we wanted to know if this spinal hyperactivity could be consecutive to an increased synaptic transmission involving ...in ...
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Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain
... ASIC3-containing channel [9], decrease pain produced by acid, inflammation, local incision and osteoarthritis, supporting the participation of peripheral ASIC3-containing channels in pain associated with ...
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en fr Involvement of nerve growth factor (NGF) and acid-sensing ion channels (ASIC) in colonic hypersensitivity induced by butyrate in the rat Étude de l'implication du nerve growth factor (NGF) et des acid-sensing ion channels (ASIC) dans l'hyper-sensibilité colique induite par le butyrate chez le rat
... ASIC1A channel contributes to ion currents evoked by painful stimulations, we wanted to know if this spinal hyperactivity could be consecutive to an increased synaptic transmission involving ...in ...
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Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives
... the channel and induces a strong shift of the pH-dependent activation of ASIC1a channel towards more acidic pH, decreasing its apparent affinity for protons (Diochot et ...the channel in the closed ...
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Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels
... ASIC1a channel by inducing a strong shift of its pH dependent activation toward more acidic pH, thus trapping the channel in its closed state ...the channel in the inactivated ...
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Zn 2+ and H + Are Coactivators of Acid-sensing Ion Channels
... tion of the necessary association with other subunits to form a homomeric channel. Analysis of the pH sensor of ASICs is complicated by the absence of other modes of activation, such as capsaicin and/or ...
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Piezo1 ion channel pore properties are dictated by C-terminal region
... touch sensing, ...that ion-permeation properties are conferred by C-terminal ...and ion selectivity, and modulates pore ...amino acid is either in the pore or closely associates with the ...
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Oxaliplatin‐induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
... of ion channels important for cold sensing Does oxaliplatin directly alter the activity of TRPM8 or does it induce downstream changes from this class of ion channels able to explain this ...
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The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen.
... Gq protein activation or ATP release to be responsible for the observed P2X 1 channel inactivation by 0.5 M ADP. The preservation of P2X 1 functionality requires the use of high concentrations of apyrase during ...
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Preparation of ion exchange membranes for fuel cell based on crosslinked poly(vinyl alcohol) with poly(styrene sulfonic acid-co-maleic acid)
... sulfonic acid groups (–SO3H) have a strong solvation property compared to ...sulfonic acid group and/or unreacted carboxylic groups of PSSA MA acted as physical crosslinking in the membrane matrix [17] ...
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Radiation grafting of acrylic acid onto chitosan beads for metal ion sorption
... Publication date 2011/7/1 Description The removal of heavy metals from aqueous solutions was investigated using natural and grafted sorbent chitosan beads, which have been grafted with acrylic acid by gamma ...
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Ca2+ influx via the platelet P2X1 ion channel contributes to collagen-induced platelet activation.
... salicylic acid against platelet aggregation, we used acetylsalicylic acid as a clearly established reference compound and confirmed that it exerts a good anti- aggregating ...acetylsalicylic acid, ...
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Modification of Hydroxyapatite with Ion-Selective Complexants: 1-Hydroxyethane-1,1-diphosphonic Acid
... longer reaction times (168 h/20 °C, mHAP6A), but an increase in temperature (4 h/80 °C, mHAP5B) resulted in a loss of only 12.3%. The temperature range and weight loss values are consistent with what has been observed in ...
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A study of Kv channel dynamics using a fluorescent unnatural amino acid
... However, under some circumstances, translation does not strictly follow the linear scanning model. One example is stop codon readthrough, where a tRNA inserts its amino acid at the stop codon [4], or the stop ...
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Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects.
... encoding ion channel subunits associated with the electrocardiographic heart- rate corrected QT (QTc) length in healthy populations of Caucasian origin (KCNH2 rs1805123 (K897T) and rs3815459, SCN5A ...
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Ion-Induced Dipole Interactions and Fragmentation Times : Cα -Cβ Chromophore Bond Dissociation Channel
... electrospray ion source as ion bunches of ~130 ns duration are mass-selected and accelerated to 5 ...pulsed ion beam intercepts the 263 nm laser pulse (100 µJ/pulse, 200 ns duration and 1 kHz pulse ...
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A dual role for the OsK5.2 ion channel in stomatal movements and K+ loading into xylem sap.
... Pubmed: Author and Title CrossRef: Author and Title Google Scholar: Author Only Title Only Author and Title Cuéllar T, Pascaud F, Verdeil JL, Torregrosa L, Adam-Blondon AF, Thibaud JB, Sentenac H, Gaillard I (2010) A ...
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