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β-catenin signaling

A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis

A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis

... Wnt/ β-catenin activation as compared with the high levels that might have been initially predicted based on previous studies in other ...Wnt/ β-catenin signaling by PKA. Specifically, ...

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A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis

A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis

... Wnt/ β-catenin activation as compared with the high levels that might have been initially predicted based on previous studies in other ...Wnt/ β-catenin signaling by PKA. Specifically, ...

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New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?

New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?

... /β-Catenin Signaling Pathway in Ewing Sarcoma The involvement of the Wnt signaling pathway in Ewing sarcoma is less described than in osteosarcoma and seems to be ...

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Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in Cancers

Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in Cancers

... indicate that KCNQ1 restricts the Wnt/ b-catenin signaling pathway activity, stabilising b-catenin at the plasma membrane. These results reveal a new role for KCNQ1: in parallel with its function of ...

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Identification and characterization of the transcriptional targets of the WNT/β-catenin signaling pathway in granulosa cells

Identification and characterization of the transcriptional targets of the WNT/β-catenin signaling pathway in granulosa cells

... regulation in response to gonadotropin stimulation, suggesting that they may function during specific phases of follicular development (34, 36, 39, 40). The first indication of the importance of Wnt signalling in ovarian ...

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Acute Exposure to Zearalenone Disturbs Intestinal Homeostasis by Modulating the Wnt/β-Catenin Signaling Pathway

Acute Exposure to Zearalenone Disturbs Intestinal Homeostasis by Modulating the Wnt/β-Catenin Signaling Pathway

... Abstract: The mycotoxin zearalenone (ZEN), which frequently contaminates cereal-based human food and animal feed, is known to have an estrogenic effect. The biological response associated with exposure to ZEN has rarely ...

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Insulin activates hepatic Wnt/β- catenin signaling through stearoyl- CoA desaturase 1 and Porcupine

Insulin activates hepatic Wnt/β- catenin signaling through stearoyl- CoA desaturase 1 and Porcupine

... insulin signaling inhibition, hepatocytes were treated with either 10 μM of Akti (Akti VIII, InVivoGen), 1 μM of wortmannin or 1 μM of rapamycin (Sigma-Aldrich) or DMSO as control, prior to incubation for 24 h in ...

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A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/β-Catenin Pathway

A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/β-Catenin Pathway

... Wnt/ β-catenin ...TCF/ β-catenin complex ICRT14 and PNU-74654 are unspecific inhibitors of the Wnt/ β-catenin ...Wnt/β-catenin signaling pathway, our method ...

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Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.

Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.

... and β-catenin staining confined to cell-cell contacts, and a dramatic reduction in nuclear β-catenin ...of β-catenin from the nucleus to adherens junctions in dense cultures was ...

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LKB1 signaling is activated in CTNNB1 -mutated HCC and positively regulates β-catenin-dependent CTNNB1 -mutated HCC

LKB1 signaling is activated in CTNNB1 -mutated HCC and positively regulates β-catenin-dependent CTNNB1 -mutated HCC

... of β-catenin) ...with β-catenin inactivation (Figure ...mutant β-catenin was required for the control of LKB1 protein expression (Figure ...canonical β-catenin ...

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Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin.

Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin.

... low β -catenin levels We produced HCT116 cell cultures stably expressing V3Nter (V3Nter-HCT116) or SFRP-1 (SFRP-1-HCT116) (Figures 1a and ...low β-catenin levels, and ~50% of cells showing low ...

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Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma

Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma

... Wnt/β-catenin signaling pathway. However, the adrenal-specific targets of oncogenic β-catenin-mediating tumorigenesis have not being ...spontaneous β-catenin activating ...

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TLR3 promotes MMP-9 production in primary human airway epithelial cells through Wnt/beta-catenin signaling.

TLR3 promotes MMP-9 production in primary human airway epithelial cells through Wnt/beta-catenin signaling.

... of β-catenin in AEC treated with poly(I:C) but not LPS ...Wnt/β-catenin signaling were not ...Wnt/β-catenin signaling [19], we hypothesized that this pathway was ...

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Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity

Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity

... protein, β-catenin, is translocated to the cell nucleus where it interacts with TCF/LEF transcription factors, displacing the Groucho repressor [ 13 ] and activating multiple target genes [ 2 , 14 , 15 ...

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Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma

Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma

... Wnt/β-catenin signaling pathway. However, the adrenal-specific targets of oncogenic β-catenin-mediating tumorigenesis have not being ...spontaneous β-catenin activating ...

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Topological and semantic Web based method for analyzing TGF-β signaling pathways

Topological and semantic Web based method for analyzing TGF-β signaling pathways

... cell signaling? 1 Université de Rennes 1 - IRISA/INRIA, UMR6074, 263 avenue du Général Leclerc, 35042 Rennes, Cedex, France 2 Université de Rennes 1 - IRSET EA 4427 SeRAIC, IFR140, 2 avenue Pr Léon Bernard, ...

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The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/beta-Catenin Signaling

The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/beta-Catenin Signaling

... Cell signaling technology) as above. To quantify  -catenin, Z-stack of five 16 bits 1024x1024 images of each condition was processed using Image ...

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Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer.

Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer.

... AR signaling in murine prostate cancers. Tumors with ß-catenin activation depend on WNT signaling to sustain tumor growth, especially under ...WNT signaling by blocking the secretion of ...

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Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by {beta}-catenin signaling

Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by {beta}-catenin signaling

... ß-catenin signaling, ß-catenin can also act through the PITX family of transcription factors [17], which are abundantly expressed in developing mesenchymal tissues ...ß-catenin-PITX ...

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Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

... Discussion Recent research has highlighted that microglia of the developing brain have a unique phenotype. The aims of this study were, the identification in MG of the developing brain of the molecular regulators of ...

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