Physiological partial aldosterone resistance in human newborns.: Aldosterone resistance at birth

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HAL Id: inserm-00383127

https://www.hal.inserm.fr/inserm-00383127

Submitted on 17 Jun 2010

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newborns.

Laetitia Martinerie, Eric Pussard, Laurence Foix-l’Hélias, François Petit,

Claudine Cosson, Pascal Boileau, Marc Lombès

To cite this version:

Laetitia Martinerie, Eric Pussard, Laurence Foix-l’Hélias, François Petit, Claudine Cosson, et al.. Physiological partial aldosterone resistance in human newborns.: Aldosterone resistance at birth. Pe-diatric Research, Nature Publishing Group, 2009, 66 (3), pp.323-8. �10.1203/PDR.0b013e3181b1bbec�. �inserm-00383127�

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Neonates Mothers 2 4 6 8 10 12 14 P la sm a K+ (mmol/l)

A

2.5 3.0 3.5 4.0 4.5 5.0 5.5 0 5 10 15 Maternal K+ (mmol/l) Neonatal K + (mmol/l) 0

B

C

Figure 1

*

20 30 40 50 60 70 80 0 20 40 60 80

Maternal creatinine (µmol/l)

Neonatal c re at in ine (µmol/l)

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Urinary

N

a/

K

Urinary creatinine (µmol/l)x 10-2

Figure 2

25 50 75 100 125 150 0 2.5 5.0 7.5 10.0

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Neonates Mothers 0 5 10 15 20 25 P la sm a al d o st er o n e (pg/ml) x 10 -2

A

Neonates Mothers 0 1 2 3 P la sm a re n in (pg/ml) x 10 -2

B

0 5 10 15 20 25 0 10 20 30 Neonatal aldosterone (pg/ml) Neonatal r en in (pg/ml)

C

x 10 x 10 -2

Figure 3

** * -2

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0 5 10 15 20 25 0 1 2 3 Neonatal aldosterone (pg/ml) U ri n ar y al d o st er o ne (pg/µg creatinine) x 10 2 x 10 -2 0 5 10 15 20 25 0 5 10 15 Neonatal aldosterone (pg/ml) Neonatal K + (mmol/l) x 10 -2 0 5 10 15 20 25 30 0 5 10 15 Urinary aldosterone (pg/ug creatinine) Neonatal K+ (mmol/l)

C

x 10

D

Urinary aldosterone distribution (pg/µg creatinine) 0 50 100 150 200 250 -1

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0 5 10 15 20 25 30 0 5 10 15 20 25 Urinary aldosterone (pg/µg creatinine) U ri n ar y K + (m m o l/ µ m o l creatinine)

A

0 5 10 15 20 25 30 0 2.5 5.0 7.5 10.0 12.5 Urinary aldosterone (pg/µg creatinine) U ri n ar y N a+ /K +

B

x 10 x 10 3 x 10

Figure 5

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