HAL Id: inserm-00383127
https://www.hal.inserm.fr/inserm-00383127
Submitted on 17 Jun 2010HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are
pub-L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non,
newborns.
Laetitia Martinerie, Eric Pussard, Laurence Foix-l’Hélias, François Petit,
Claudine Cosson, Pascal Boileau, Marc Lombès
To cite this version:
Laetitia Martinerie, Eric Pussard, Laurence Foix-l’Hélias, François Petit, Claudine Cosson, et al.. Physiological partial aldosterone resistance in human newborns.: Aldosterone resistance at birth. Pe-diatric Research, Nature Publishing Group, 2009, 66 (3), pp.323-8. �10.1203/PDR.0b013e3181b1bbec�. �inserm-00383127�
Neonates Mothers 2 4 6 8 10 12 14 P la sm a K+ (mmol/l)
A
2.5 3.0 3.5 4.0 4.5 5.0 5.5 0 5 10 15 Maternal K+ (mmol/l) Neonatal K + (mmol/l) 0B
C
Figure 1
*
20 30 40 50 60 70 80 0 20 40 60 80Maternal creatinine (µmol/l)
Neonatal c re at in ine (µmol/l)
Urinary
N
a/
K
Urinary creatinine (µmol/l)x 10-2
Figure 2
25 50 75 100 125 150 0 2.5 5.0 7.5 10.0Neonates Mothers 0 5 10 15 20 25 P la sm a al d o st er o n e (pg/ml) x 10 -2
A
Neonates Mothers 0 1 2 3 P la sm a re n in (pg/ml) x 10 -2B
0 5 10 15 20 25 0 10 20 30 Neonatal aldosterone (pg/ml) Neonatal r en in (pg/ml)C
x 10 x 10 -2Figure 3
** * -20 5 10 15 20 25 0 1 2 3 Neonatal aldosterone (pg/ml) U ri n ar y al d o st er o ne (pg/µg creatinine) x 10 2 x 10 -2 0 5 10 15 20 25 0 5 10 15 Neonatal aldosterone (pg/ml) Neonatal K + (mmol/l) x 10 -2 0 5 10 15 20 25 30 0 5 10 15 Urinary aldosterone (pg/ug creatinine) Neonatal K+ (mmol/l)
C
x 10D
Urinary aldosterone distribution (pg/µg creatinine) 0 50 100 150 200 250 -1
0 5 10 15 20 25 30 0 5 10 15 20 25 Urinary aldosterone (pg/µg creatinine) U ri n ar y K + (m m o l/ µ m o l creatinine)
