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Figure 2A

applicability bias MSE λ P CI success λ H CI success

g 0 = 10 2

g 0 = 10 4

g 0 = 10 6

N e = 1 00

g 0 = 10 2

g 0 = 10 4

g 0 = 10 6 g 0 = 10 2

g 0 = 10 4

g 0 = 10 6

N e = 1 00 0 N e = 1 0

p p

p p

c c

c c

g g g g

l l l l

m m m m

x x x x

p p c c

c c

g g

g g

l l

l l

m m

m m

x x

x x

p p c

c c

c

g g

g g

l l

l l

m m

m m

x x

x

x

p p c

c c

c

g g

g g

l l

l l

m m

m m

x x

x x

p p

c c c

c

g g

g

g

l l

l l

m m

m m

x x

x x

1 10 100 1000

p p

p p

c c

c c

g g g g

l l

l l

m m m m

x x x x

p p c c c

c

g g g

g

l l

l l

m m m m

x x x x

p p c

c c

c

g g

g g

l l

l l

m m m

m

x x

x x

p p

c c

c c

g g

g

g

l l l

l

m m m

m

x x

x x

p p

c c

c c

g g g

g

l l l

l

m m

m m

x x

x x

1 10 100 1000

p p

p p

c c

c c

g g g g

l l

l l

m m m m

x x x x

p p c c c

c

g g g

g

l l

l l

m m m m

x x x x

p p c

c c

c

g g

g g

l l

l l

m m m

m

x x

x x

p p c

c c

c

g g

g

g

l l l

l

m m m

m

x x

x x

p p

c c

c c

g g

g

g

l l l

l

m m

m m

x x

x x

1 10 100 1000

p p

p p

c c c c

g g g g

l l l l

m m m m

x x x x

100 80 60 40 20 0

p p

c c

c c

g g

g g

l l

l l

m m

m m

x x

x x

-0.5 -0.3 -0.1 0.0 0.1 0.3 0.5

p p

c c

c c

g g

g g

l l

l l

m m

m m

x x

x

x

0.0 0.1 0.2 0.3 0.4 0.5

p p c

c c

c

g g

g g

l l

l l

m m

m m

x x

x x

1.0 0.8 0.6 0.4 0.2 0.0

p p c

c c

c

g g

g

g

l l

l l

m m

m m

x x

x x

1.0 0.8 0.6 0.4 0.2 0.0

1 10 100 1000

p p

p

p

c c

c c

g g g g

l l l l

m m m m

x x x x

p p p

c c c

c

g g g

g

l l l

l

m m m m

x x x

x

p p

p

c c

c c

g g

g g

l l

l

l

m m m

m

x x x

x

p p p

c c c

c

g g

g

g

l l l

l

m m m

m

x x

x

x

p p p

c c c c

g g g

g

l l l l

m m

m m

x x

x x

1 10 100 1000

p p

p

p

c c c

c

g g g g

l l l

l

m m m m

x x x x

p p p

c c c c

g g g

g

l l l

l

m m m m

x x x

x

p p

p

c c c

c

g g g

g

l l

l l

m m m

m

x x x

x

p p p

c c c

c

g g

g

g

l l l

l

m m m

m

x x

x

x

p p p

c c c c

g g g

g

l l l

l

m m

m m

x x

x x

1 10 100 1000

p p

p p

c c c c

g g g g

l l l l

m m m m

x x x x

100 80 60 40 20 0

p p

c c

c c

g g

g g

l l

l l

m m

m m

x x

x x

-0.5 -0.3 -0.1 0.0 0.1 0.3 0.5

p p

c c

c c

g g

g g

l l

l l

m m

m m

x x

x x

0.0 0.1 0.2 0.3 0.4 0.5

p p c

c c

c

g g

g g

l l

l l

m m

m m

x x

x x

1.0 0.8 0.6 0.4 0.2 0.0

p p c

c c

c

g g

g g

l l

l l

m m

m m

x x

x x

1.0 0.8 0.6 0.4 0.2 0.0

1 10 100 1000

p p p

p

c c c

c

g g g g

l l l l

m m m m

x x x x

p p p

p

c c c

c

g g g

g

l l l

l

m m m

m

x x x x

p p p

p

c c c

c

g g g

g

l l

l l

m m m

m

x x x

x

p p p p

c c c

c

g g

g

g

l l

l l

m m m

m

x x

x x

p p p p

c c c c

g g

g

g

l l

l l

m m m

m

x x

x x

1 10 100 1000

p p p

p

c c c

c

g g g g

l l l l

m m m m

x x x x

p p p p

c c c c

g g g

g

l l l

l

m m m m

x x x x

p p p

p

c c c

c

g g g

g

l l l

l

m m m

m

x x x

x

p p

p p

c c c c

g g

g

g

l l l

l

m m m

m

x x

x x

p p p

p

c c

c c

g g

g g

l l l

l

m m m

m

x x

x x

1 10 100 1000

(2)

Figure 2B

applicability bias MSE λ P CI success λ H CI success

g 0 = 10 2

g 0 = 10 4

g 0 = 10 6

N e = 1 00

g 0 = 10 2

g 0 = 10 4

g 0 = 10 6 g 0 = 10 2

g 0 = 10 4

g 0 = 10 6

N e = 1 00 0 N e = 1 0

p p

p p

c c

c c

g g g g

l l l l

m m m m

x x x x

p p c c c c

g g g g

l l l l

m m m m

x x x x

p p c

c c c

g g

g g

l l

l l

m m

m m

x x

x x

p p c c c c

g g

g g

l l

l l

m m m

m

x x

x x

p p c

c c c

g g g g

l l l l

m m m m

x x

x x

1 10 100 1000

p p

p p

c c c

c

g g g g

l l l l

m m m m

x x x x

p p c c c c

g g g g

l l l l

m m m m

x x x x

p p c

c c c

g g

g g

l l

l l

m m

m m

x x

x x

p p c c c c

g g g

g

l l l

l

m m m

m

x x

x x

p p

c c c c

g g g g

l l l l

m m m

m

x x

x x

1 10 100 1000

p p

p p

c c c

c

g g g g

l l l l

m m m m

x x x x

p p c c c c

g g g g

l l l l

m m m m

x x x x

p p c

c c c

g g

g g

l l

l l

m m

m m

x x

x x

p p c c c c

g g g

g

l l l l

m m m

m

x x

x x

p p

c c c c

g g g g

l l l l

m m m

m

x x

x x

1 10 100 1000

p p

p

p

c c

c c

g g

g g

l l l l

m m m m

x x x x

100 80 60 40 20 0

p p

p

c c c c

g g g g

l l l l

m m m m

x x x x

-0. 5 -0. 3 -0. 1 0. 0 0. 1 0. 3 0. 5

p p

p

c c

c c

g g

g g

l l

l l

m m

m m

x x

x x

0. 0 0. 1 0. 2 0. 3 0. 4 0. 5

p p

p

c c c c

g g g

g

l l l l

m m m m

x x

x x

1. 0 0. 8 0. 6 0. 4 0. 2 0. 0

p p

p

c c c c

g g g

g

l l l l

m m m m

x x

x x

1. 0 0. 8 0. 6 0. 4 0. 2 0. 0

1 10 100 1000

p p

p

p

c c c c

g g g g

l l l l

m m m m

x x x x

p p p

c c c c

g g g g

l l l l

m m m m

x x x x

p p

p

c c

c c

g g g

g

l l

l l

m m m

m

x x

x

x

p p p

c c c c

g g g

g

l l l

l

m m m

m

x x x

x

p p p

c c c c

g g g g

l l l l

m m m

m

x x

x

x

1 10 100 1000

p p

p

p

c c c c

g g g g

l l l l

m m m m

x x x x

p p p

c c c c

g g g g

l l l l

m m m m

x x x x

p p

p

c c

c c

g g g

g

l l l

l

m m m

m

x x

x

x

p p p

c c c c

g g g

g

l l l l

m m m

m

x x x

x

p p p

c c c c

g g g g

l l l l

m m m m

x x

x

x

1 10 100 1000

p p

p p

c c c c

g g g g

l l l l

m m m m

x x x x

100 80 60 40 20 0

p p c c c c

g g g g

l l l l

m m m m

x x x x

-0. 5 -0. 3 -0. 1 0. 0 0. 1 0. 3 0. 5

p p

c c c c

g g g

g

l l

l l

m m

m m

x x

x x

0. 0 0. 1 0. 2 0. 3 0. 4 0. 5

p p c c

c c

g g g

g

l l l l

m m m

m

x x

x x

1. 0 0. 8 0. 6 0. 4 0. 2 0. 0

p p c c

c c

g g g

g

l l l l

m m m

m

x x

x x

1. 0 0. 8 0. 6 0. 4 0. 2 0. 0

1 10 100 1000

p p p

p

c c c c

g g g g

l l l l

m m m m

x x x x

p p p p

c c c c

g g g g

l l l l

m m m m

x x x x

p p p

p

c c c

c

g g g

g

l l l

l

m m m

m

x x x

x

p p p

p

c c c c

g g g

g

l l l l

m m m m

x x

x

x

p p p p

c c c c

g g g g

l l l l

m m m m

x x

x x

1 10 100 1000

p p p

p

c c c c

g g g g

l l l l

m m m m

x x x x

p p p p

c c c c

g g g g

l l l l

m m m m

x x x x

p p p

p

c c c

c

g g g

g

l l l

l

m m m

m

x x x

x

p p p

p

c c c c

g g g g

l l l l

m m m m

x x x

x

p p p p

c c c c

g g

g g

l l l l

m m m m

x x x

x

1 10 100 1000

(3)

Figure 3A

N e = 1 0

n loc

ss

n loc

ss

n loc

N = 1 00 0 N = 1 00 e e ss

applicability bias O MSE O λ P CI success λ H CI success

c c c

5 10 15 20

02060100

p p p

g g g

l l l

mx mx mx

c c c

5 10 15 20

-0.10.1 g g g

l l

mx m ml

x x

c c

c

5 10 15 20

0.050.150.25

g g g

l l

m l

m m

x x x

c c c

5 10 15 20

0.00.40.8

g g g

l l l

m m m

x x

x c c c

5 10 15 20

0.00.40.8

gl gl gl

m m m

x x

x

c c c

20 40 60 80

02060100

p p p

gl gl gl

mx mx mx

c c c

20 40 60 80

-0.10.1

p p p

gl gl gl

m m m

x x x c c c

20 40 60 80

0.050.150.25

p p p

g g g

l l l

mx mx mx

c c c

20 40 60 80

0.00.40.8 p p p

gl gl gl

m m m

x x x c c c

20 40 60 80

0.00.40.8p p p

gl gl gl

m m m

x x x

c c c

5 10 15 20

02060100

p p p

gl gl gl

mx mx mx

c c c

5 10 15 20

-0.10.1

p p p

gl gl gl

mx m m

x x c c

c

5 10 15 20

0.050.150.25

p p

p

g g g

l l m l

m m

x

x x

c c c

5 10 15 20

0.00.40.8 p p p

g g g

l l l

m m m

x x x c c c

5 10 15 20

0.00.40.8p p p

g g g

l l l

m m m

x x

x

c c c

20 40 60 80

02060100

p p p

gl gl gl

mx mx mx

c c c

20 40 60 80

-0.10.1

p p p

gl gl gl

mx mx mx c c c

20 40 60 80

0.050.150.25

p p p

gl gl gl

mx mx mx

c c c

20 40 60 80

0.00.40.8 p p p

gl gl gl

m m m

x x x c c c

20 40 60 80

0.00.40.8p p p

gl gl gl

m m m

x x x

c c c

5 10 15 20

02060100

p p p

gl gl gl

mx mx mx

c c c

5 10 15 20

-0.10.1

p p p

gl gl gl

mx mx mx c c c

5 10 15 20

0.050.150.25

p p p

gl g g

l l

mx mx mx

c c c

5 10 15 20

0.00.40.8

p p p

g g

g

l l

l

m m

x x m

x c c c

5 10 15 20

0.00.40.8

p p p

g g

g

l l

l

m m m

x x

x

c c c

20 40 60 80

02060100

p p p

gl gl gl

mx mx mx

c c c

20 40 60 80

-0.10.1 p p p

gl g g

l l

mx mx mx c c c

20 40 60 80

0.050.150.25

p

p p

g g g

l

l l

m m m

x x x

c c c

20 40 60 80

0.00.40.8

p p p

gl gl gl

mx mx mx c c c

20 40 60 80

0.00.40.8

p p p

gl gl gl

m m m

x x x

(4)

Figure 3B

N e = 1 0

n loc

ss

n loc

ss

n loc

N = 1 00 0 N = 1 00 e e ss

applicability bias O MSE O λ P CI success λ H CI success

c c c

5 10 15 20

02060100

p p p

gl gl gl

m m m

x x x

c c c

5 10 15 20

-0.10.1

gl gl gl

mx mx mx

c c

c

5 10 15 20

0.050.150.25

g

g g

l

l l

m m

m

x x x

c c c

5 10 15 20

0.00.40.8 g g gl l lm m mx x

x c c c

5 10 15 20

0.00.40.8 g g gl l l

m m m

x x x

c c c

20 40 60 80

02060100

p p p

gl gl gl

m m m

x x x

c c c

20 40 60 80

-0.10.1

p p p

gl gl gl

mx mx mx

c c c

20 40 60 80

0.050.150.25

p p p

gl gl gl

m m m

x x x

c c c

20 40 60 80

0.00.40.8 p p pg g gl l lm m m

x x x c c c

20 40 60 80

0.00.40.8 p p pg g gl l lm m m

x x x

c c c

5 10 15 20

02060100

p p p

gl gl gl

m m m

x x x

c c c

5 10 15 20

-0.10.1

p p p

gl gl gl

mx mx mx

c c c

5 10 15 20

0.050.150.25

p p p

g

g g

l

l l

m

m m

x x x

c c c

5 10 15 20

0.00.40.8 p p pg g gl l l

mx mx mx c c c

5 10 15 20

0.00.40.8 p p pg g gl l l

m m m

x x x

c c c

20 40 60 80

02060100

p p p

gl gl gl

m m m

x x x

c c c

20 40 60 80

-0.10.1

p p p

gl gl gl

mx mx mx c c c

20 40 60 80

0.050.150.25

p p p

gl gl gl

m m m

x x x

c c c

20 40 60 80

0.00.40.8 p p pg g gl l lm m mx x x c c c

20 40 60 80

0.00.40.8 p p pg g gl l lm m mx x x

c c c

5 10 15 20

02060100

p p p

gl gl gl

m m m

x x x

c c c

5 10 15 20

-0.10.1

p p p

gl gl gl

mx mx mx c c c

5 10 15 20

0.050.150.25

p p p

g g

g l

l l

m

m m

x x x

c c c

5 10 15 20

0.00.40.8 p p pg g gl l lm m mx x x c c c

5 10 15 20

0.00.40.8

p p p

gl gl gl

m m m

x x x

c c c

20 40 60 80

02060100

p p p

gl gl gl

m m m

x x x

c c c

20 40 60 80

-0.10.1

p p p

gl gl gl

mx mx mx c c c

20 40 60 80

0.050.150.25

p p p

gl gl gl

m m m

x x x

c c c

20 40 60 80

0.00.40.8 p p p

gl gl gl

mx mx m

x c c c

20 40 60 80

0.00.40.8 p

p p

gl gl gl

m m m

x x

x

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