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Spatial competition constrains resistance to targeted cancer therapy

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Academic year: 2021

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Fig. 1 Mathematical modelling of tumour evolutionary dynamics. a In mathematical modelling of cancer treatment outcomes, the function f describing the relationship between resistant cell relative fi tness and frequency may be assumed to be linear (solid cur
Fig. 2 Cell cycle rewiring in CDKi-resistant cells. a HCT116 WT and R50 early and late cells were grown in the absence or presence of 50 μ M NU6102 and the cell number was evaluated every day for 6 days
Fig. 3 CDKi-resistant cells have lower proliferative fi tness in vitro and in vivo. a WT and R50 cells were grown in 1% O 2
Fig. 4 AT does not outperform MTD in limiting tumour growth in a monolayer culture. a Sensitive GFP+ and R50 mCherry+ cells were plated in monolayer at initial 99:1 ratio, in the presence of either DMSO as control or NU6102: AT condition (15 μ M initial dr
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