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Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins

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Academic year: 2021

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Figure

Figure 1. Affinity-matured p19 clones display high affinity and stability. (A) SEC analysis of the p19 clones
Figure 2. Characterization of EGFR-targeted p19 clones. (A) Model structures of the targeted p19 constructs used in this study
Figure 3. Potent, affinity-dependent silencing mediated by the targeted siRNA carriers
Figure 4. Silencing of endogenous PLK1 is affinity dependent. A431 cells were transfected with p19-E18 or p19-E18 N15K,G16R that were loaded with either PLK1 siRNA or negative control (NEG) siRNA
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