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Safe and efficient novel approach for non-invasive gene electrotransfer to skin

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Academic year: 2021

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Figure 1.  Gene electrotransfer in vivo. (A) Electrode set-up applied on the mouse skin
Figure 3.  Optimization of the HV-MV parameters for cutaneous transgenic expression. Plasmid DNA (25 µg)  encoding the fluorescent protein tdTomato were intradermally injected in the back of anesthetized C57Bl/6  mice and the electrotransfer was performed
Figure 5.  Time dependence of the voltage present between the electrodes under the unipolar and bipolar  settings
Figure 8.  pIL-12 GET induces expression and secretion of IL-12. Mice were intradermally injected with  25 µg of pIL-12 in 20 µl PBS, or with 20 µl of PBS alone in one flank and were submitted to HV-MV electrical  treatment
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