Article
Reference
Baboon syndrome due to amoxicillin: an unusual complication
CORREIA, Jorge, FUBINI, Pietro Elias
Abstract
This is an illustration of a case of “Baboon Syndrome” related to the use of Amoxicilin.
“Baboon syndrome”, or symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) as it is more correctly termed, is a rare type IV hypersensitivity reaction causing a maculopapular rash. It is an unusual complication of several medications with Amoxicillin and other beta lactam antibiotics accounting for about half of cases. Given the frequent use of this antibiotic, it is important that clinicians recognize this side effect arising from this treatment.
CORREIA, Jorge, FUBINI, Pietro Elias. Baboon syndrome due to amoxicillin: an unusual complication. Journal of Case Reports and Medical Images , 2019, vol. 2, no. 1, p. 1028
Available at:
http://archive-ouverte.unige.ch/unige:136971
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Baboon syndrome due to amoxicillin: an unusual complication
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MedDocs Publishers
Received: Sep 09, 2019 Accepted: Oct 30, 2019 Published Online: Nov 04, 2019
Journal: Journal of Case Reports and Medical Images Publisher: MedDocs Publishers LLC
Online edition: http://meddocsonline.org/
Copyright: © Correia JC (2019). This Article is distributed under the terms of Creative Commons Attribution 4.0 International License
*Corresponding Author(s): Jorge César Correia Department of Community Medicine, Primary and Emergency Care, Geneva University Hospitals and University of Geneva 1205 Geneva, Switzerland Email: jorgecesar.correia@hcuge.ch
Journal of Case Reports and Medical Images
Open Access | Clinical Image
Cite this article: Correia JC, Fubini PE. Baboon syndrome due to amoxicillin: An unusual complication. J Case Rep Clin Images. 2019; 2(1): 1028.
ISSN: 2639-9237
Clinical Image Description
A 30-year-old man, with no known medical conditions or history of allergies, was prescribed Amoxicillin after a common dental extraction. On the same day he rapidly developed a hitching maculopapular rash on his buttock, genitals and ingui- nal area (Figure 1).
Clinical presentation and cutaneous biopsy were consistent with Baboon Syndrome equally known as Symmetrical Drug-Re- lated Intertriginous and Flexural Exanthema (SDRIFE). Amoxicil- lin was discontinued and the patient treated with a short course of systemic and topical steroids experiencing full recovery.
Jorge César Correia1*; Pietro Elias Fubini2
1Department of Community Medicine, Primary and Emergency Care, Geneva University Hospitals and University of Geneva 1205 Geneva, Switzerland
2Department of Internal Medicine, Geneva University Hospitals 1205 Geneva, Switzerland
SDRIFE is an uncommon drug-related rash occurring hours to days after exposure to the offending drug, that classically pres- ents as a V-shaped well demarcated erythema in the gluteal, inguinal and peri-genital area (green arrows). Amoxicillin and other antibiotics (mostly beta-lactams) are often involved, but many other drugs have also been implicated. As for our patient, treatment usually includes discontinuing the suspected drug and use of topical and/or systemic corticosteroids.
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MedDocs Publishers
Journal of Case Reports and Medical Images
Figure 1: Symmetrical Drug-Related Intertriginous and Flexural Exanthema due to Amoxicillin
