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DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease

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Academic year: 2021

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Fig. 2. Adenoviral overexpression of hepatic DEPTOR inhibits mTORC1 and improves hepatic  steatosis in chronic-binge ethanol-fed mice
Fig. 3. Hepatic overexpression of DEPTOR ameliorates alcohol-mediated dysregulation of lipid  metabolism in chronic-binge ethanol-fed mice
Fig. 4. Pharmacologic intervention via mTORC1 inhibition reduces hepatic lipogenesis,  stimulates fatty acid oxidation, and ameliorates hepatic steatosis in chronic-binge ethanol-fed  mice
Fig. 5. Hepatic S6K1 activity is required for the proteolytic activation of SREBP-1 and its  lipogenic process in mice after chronic-binge ethanol feeding
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