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In vitro study of carbon black nanoparticles on human pulmonary artery endothelial cells: effects on calcium signaling and mitochondrial alterations

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Academic year: 2021

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Fig. 1 Size distribution of FW2 NPs in endothelial cell growth medium measured by DLS
Fig. 2 Cell viability and intracellular ROS production in HPAEC. a Cell viability after 24-h exposure with FW2 NPs (1–10 µg/cm 2 ) measured by WST-1 colorimetric assay
Fig. 3 Cytoplasmic basal calcium level ([Ca 2+ ] c ) in HPAEC. Cal- Cal-cium level was measured with Fluo-4, AM probe (1 µM), by confo-cal microscopy
Figure 6a shows, in HPAEC, a statistically significant and concentration-dependent increase in [Ca 2+ ] m induced by FW2 NPs (5, 7.5 and 10 µg/cm 2 ) as compared to con-trol cells (19.1%, P < 0.01; 45.6% and 55.1%, P < 0.001)
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