HAL Id: tel-02420531
https://tel.archives-ouvertes.fr/tel-02420531v2
Submitted on 20 Dec 2019
HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci- entific research documents, whether they are pub- lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.
L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Rôle des interactions entre la mitochondrie et le reticulum endoplasmique dans les défauts de sécrétion d’insuline par les cellules béta pancréatiques au cours du
diabète de type 2
Florian Dingreville
To cite this version:
Florian Dingreville. Rôle des interactions entre la mitochondrie et le reticulum endoplasmique dans les défauts de sécrétion d’insuline par les cellules béta pancréatiques au cours du diabète de type 2. Endocrinologie et métabolisme. Université de Lyon, 2018. Français. �NNT : 2018LYSE1341�.
�tel-02420531v2�
1. Henquin JC, Ravier MA, Nenquin M, Jonas JC, Gilon P. Hierarchy of the beta-cell signals controlling insulin secretion. Eur J Clin Invest. 2003 Sep;33(9):742 50.
2. Rutter GA, Pullen TJ, Hodson DJ, Martinez-Sanchez A. Pancreatic -cell identity, glucose sensing and the control of insulin secretion. Biochem J. 2015 Mar 1;466(2):203 18.
3. Maechler P, Carobbio S, Rubi B. In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion. Int J Biochem Cell Biol. 2006;38(5 6):696 709.
4. Arunagiri A, Haataja L, Cunningham CN, Shrestha N, Tsai B, Qi L, et al. Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes. Ann N Y Acad Sci. 2018 Apr;1418(1):5 19.
5. Bensellam M, Laybutt DR, Jonas J-C. The molecular mechanisms of pancreatic -cell glucotoxicity: recent findings and future research directions. Mol Cell Endocrinol.
2012 Nov 25;364(1 2):1 27.
6. Eizirik DL, Korbutt GS, Hellerström C. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. J Clin Invest. 1992 Oct;90(4):1263 8.
7. Fex M, Nicholas LM, Vishnu N, Medina A, Sharoyko VV, Nicholls DG, et al. The pathogenetic role of -cell mitochondria in type 2 diabetes. J Endocrinol. 2018 Mar;236(3):R145 59.
8. Karunakaran U, Kim H-J, Kim J-Y, Lee I-K. Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and -cell failure in type II diabetes. Exp Diabetes Res.
2012;2012:639762.
9. Madec A-M, Cassel R, Dubois S, Ducreux S, Vial G, Chauvin M-A, et al. Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway. FASEB J Off Publ Fed Am Soc Exp Biol. 2013 Dec;27(12):5122 30.
10. Anello M, Lupi R, Spampinato D, Piro S, Masini M, Boggi U, et al. Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia. 2005 Feb;48(2):282 9.
11. Barlow J, Affourtit C. Novel insights into pancreatic -cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells. Biochem J. 2013 Dec 15;456(3):417 26.
12. Masini M, Anello M, Bugliani M, Marselli L, Filipponi F, Boggi U, et al. Prevention by metformin of alterations induced by chronic exposure to high glucose in human islet beta cells is associated with preserved ATP/ADP ratio. Diabetes Res Clin Pract.
2014 Apr;104(1):163 70.
13. Yoon Y, Galloway CA, Jhun BS, Yu T. Mitochondrial dynamics in diabetes. Antioxid Redox Signal. 2011 Feb 1;14(3):439 57.
14. Filadi R, Theurey P, Pizzo P. The endoplasmic reticulum-mitochondria coupling in health and disease: Molecules, functions and significance. Cell Calcium. 2017;62:1 15.
15. Herrera-Cruz MS, Simmen T. Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs). Adv Exp Med Biol. 2017;997:13 31.
16. Tubbs E, Theurey P, Vial G, Bendridi N, Bravard A, Chauvin M-A, et al.
Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance. Diabetes.
2014 Oct;63(10):3279 94.
17. Tubbs E, Chanon S, Robert M, Bendridi N, Bidaux G, Chauvin M-A, et al. Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans. Diabetes.
2018;67(4):636 50.
18. Rieusset J, Fauconnier J, Paillard M, Belaidi E, Tubbs E, Chauvin M-A, et al.
Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance.
Diabetologia. 2016 Mar;59(3):614 23.
19. Thivolet C, Vial G, Cassel R, Rieusset J, Madec A-M. Reduction of endoplasmic reticulum- mitochondria interactions in beta cells from patients with type 2 diabetes.
PloS One. 2017;12(7):e0182027.
20. Merglen A, Theander S, Rubi B, Chaffard G, Wollheim CB, Maechler P. Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology. 2004 Feb;145(2):667 78.
21. Csordás G, Renken C, Várnai P, Walter L, Weaver D, Buttle KF, et al. Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol. 2006 Sep 25;174(7):915 21.
22. Weaver D, Bartok A, Csordas G, Hajnoczky G. A Standardized Method to Quantify ER-Mitochondrial Interfaces in Electron Mircographs. Biophysical Journal. 112(3), 133a. 2017;
23. Tubbs E, Rieusset J. Study of Endoplasmic Reticulum and Mitochondria Interactions by In Situ Proximity Ligation Assay in Fixed Cells. J Vis Exp JoVE. 2016 10;(118).
24. Palmer AE, Giacomello M, Kortemme T, Hires SA, Lev-Ram V, Baker D, et al. Ca2+
indicators based on computationally redesigned calmodulin-peptide pairs. Chem Biol.
2006 May;13(5):521 30.
25. Rodriguez-Garcia A, Rojo-Ruiz J, Navas-Navarro P, Aulestia FJ, Gallego-Sandin S, Garcia-Sancho J, et al. GAP, an aequorin-based fluorescent indicator for imaging Ca2+ in organelles. Proc Natl Acad Sci. 2014 Feb 18;111(7):2584 9.
26. Bonnard C, Durand A, Peyrol S, Chanseaume E, Chauvin M-A, Morio B, et al.
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet- induced insulin-resistant mice. J Clin Invest. 2008 Feb;118(2):789 800.
27. Theurey P, Tubbs E, Vial G, Jacquemetton J, Bendridi N, Chauvin M-A, et al.
Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver. J Mol Cell Biol. 2016 Apr;8(2):129 43.
28. Jhun BS, Lee H, Jin Z-G, Yoon Y. Glucose stimulation induces dynamic change of mitochondrial morphology to promote insulin secretion in the insulinoma cell line INS-1E. PloS One. 2013;8(4):e60810.
29. Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GS. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med. 2014 Dec;20(12):1427 35.
30. Gilon P, Chae H-Y, Rutter GA, Ravier MA. Calcium signaling in pancreatic -cells in health and in Type 2 diabetes. Cell Calcium. 2014 Nov;56(5):340 61.
31. Molina AJA, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, et al.
Mitochondrial networking protects beta-cells from nutrient-induced apoptosis.
Diabetes. 2009 Oct;58(10):2303 15.
32. Rieusset J. The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update. Cell Death Dis. 2018 Mar 9;9(3):388.
33. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.
Cell. 2010 Jul 23;142(2):270 83.
34. Masini M, Martino L, Marselli L, Bugliani M, Boggi U, Filipponi F, et al.
Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus. Diabetes Metab Res Rev. 2017;33(6).
35. Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, Bortell R, et al. Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab. 2006 Sep;4(3):245 54.
36. Kono T, Tong X, Taleb S, Bone RN, Iida H, Lee C-C, et al. Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic cell. Diabetes. 2018 Aug 21;
37. Gwiazda KS, Yang T-LB, Lin Y, Johnson JD. Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E690-701.
38. Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, et al. Increased ER- mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci. 2011 Jul 1;124(Pt 13):2143 52.
