Proteasome dysfunction mediates high glucose-induced apoptosis in rodent beta cells and human islets

Under conditions of permissive, clamped [ Ca 2 + ] c in permeabilized cells, exogenous glutamate directly stimulates insulin exocytosis independently of mitochondrial

Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6.. Effects of depletion of mitochondrial DNA in

Finally, to show that Fas signaling by itself can lead to proliferation, Fas receptor was blocked in islets exposed for 2 days to high glucose, a time point when ␤ cell proliferation

Here we demonstrate that high concentrations of glucose induce IL-1 β production and secretion in human β cells, leading to Fas receptor upregulation, NF-κB activation, β

suppression of HNF-1 ␣ function in INS-1 insulinoma cells ac- tivates the evolutionary conserved apoptotic cell death machin- ery via alterations in gene expression and

Loss of beta-cell mass and function raises a concern regarding the application of sulfonylureas for the treatment of type 2 diabetes because previous studies have shown that agents

Effects of glucose treatment on the MAPK ERK1/2 and AMPK phosphorylation and on the adiponectin receptor expression in rat granulosa cells.. We examined whether the inhibitory

The proposed test statistics T R can accomodate either proportional hazards or nonproportional hazards with better observed power when sample size formula accounting for competing