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Detection of IgM/IgG antibodies to the novel coronavirus (SARS-CoV-2) in cardiology caregivers using a qualitative detection kit

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Letter to the editor | Published 04 August 2020 | doi:10.4414/cvm.2020.02120 Cite this as: Cardiovasc Med. 2020;23:w02120

Detection of IgM/IgG antibodies to the novel

coronavirus (SARS-CoV-2) in cardiology

caregivers using a qualitative detection kit

Schukraft Sara, Fellay Benoît, Togni Mario, Magnin Jean-Luc, Nordmann Patrice, Cook Stéphane University and Hospital Fribourg, Switzerland

Since 25 February 2020, Switzerland has been affected by the coronavirus disease-2019 (COVID-19) pandemic and has one of the highest number of cases per capita in the world. Cardiology caregivers are also at risk. One third of COVID-19 patients have cardiac involvement and re-quire specific investigations involving close contact with patients (e.g., transthoracic echocardiography, transoe-sophageal echocardiography, coronary angiography). As standard in our hospital, a surgical mask is worn by care-givers at all times. The standard “droplet” isolation pre-cautions are taken for any patient with symptoms com-patible with COVID-19. Transthoracic, transoesophageal and stress echocardiography in patients for whom test re-sults were not likely to change the management strategy are avoided [1].

We sought to use a rapid antibody test to detect recent COVID-19 infection in cardiac caregivers 1 month after the pandemic peak to assess the effectiveness of the pre-ventive measures put in place.

Our laboratory has tested three rapid antibody tests for COVID-19. The SARS-CoV-2 immunoglobulin (Ig) M / IgG antibody Rapid Test (Sure Biotech Ltd. Hong Kong) was considered to produce the most reliable results, a

sitivity of 82% and specificity of 96% for IgM, and a sen-sitivity 93% and specificity of 98% for IgG. All cardiol-ogy department staff who worked in the clinic during the pandemic were invited to complete a health summary form on the presence of symptoms of viral infection in the first quarter of 2020 and to undergo the capillary blood test (fig. 1). All tests were completed by 23 April 2020. The collec-tion of data for quality control was approved by the Insti-tutional Board.

In the ward, 54 caregivers were working at the beginning of the outbreak (17 physicians, 28 nurses and 9 administra-tive staff). There were twice as many women (n = 36) as men (n = 18). The average age was 44.5 ± 9.7 years and 5 people were <30 years old. Two subjects defined as mem-bers of a risk group were quarantined and excluded from the analysis.

All 52 caregivers were tested. The results were as follows. All asymptomatic caregivers (n = 41) were negative for both IgG and IgM. Nine symptomatic caregivers with in-fluenza-like symptoms had a negative rapid test. In only two symptomatic caregivers the rapid test showed antibod-ies (IgG: 2/2, IgM: 1/2), equivalent to 4% of the tested population. The two caregivers who were positively tested

Correspondence: Sara Schukraft, MD, Cardi-ology, University and Hos-pital Fribourg, CH-1708 Fribourg,

sara.schukraft[at]h-fr.ch

Figure 1: COVID-19 rapid testing in cardiology caregivers.

Cardiovascular Medicine · PDF of the online version · www.cardiovascmed.ch

Published under the copyright license “Attribution – Non-Commercial – No Derivatives 4.0”. No commercial reuse without permission. See http://emh.ch/en/services/permissions.html.

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had also had a previous positive nasopharyngeal swab test. Both infections occurred within the family circle.

We draw several conclusions. The incidence of caregivers with positive serology is extremely low. This suggests that the safeguards in place to limit the risk of contamination of caregivers are efficient. However, this test cannot evaluate contagiousness or immunity, as it only provides evidence of a recent infection. Finally, rapid serological testing for COVID-19 can help to determine the impact of protection strategies for caregivers and guide the choice of the best strategy to follow in a hospital setting.

Financial disclosure

Fonds Scientifique Cardiovasculaire, Fribourg Potential competing interests

No conflict of interest was reported References

1 The European Society for Cardiology. ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance.

Letter to the editor Cardiovasc Med. 2020;23:w02120

Cardiovascular Medicine · PDF of the online version · www.cardiovascmed.ch

Published under the copyright license “Attribution – Non-Commercial – No Derivatives 4.0”. No commercial reuse without permission. See http://emh.ch/en/services/permissions.html.

Figure

Figure 1: COVID-19 rapid testing in cardiology caregivers.

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