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Glucose‐6‐Phosphate Regulates Hepatic Bile Acid Synthesis in Mice

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Academic year: 2021

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FIg. 1. Hepatic G6P accumulation modifies bile acid synthesis. (A) Hepatic mRNA levels of bile acid synthesis genes and (B) biliary  bile acid composition in C57BL/6 mice infused with S4048 or vehicle (n = 7)
taBle 1. Bile Characteristics in Chow-Fed Male l-G6pc −/−  Mice and Wt littermates
FIg. 2. ChREBP mediates induction of Cyp8b1 in response to hepatic G6P accumulation. (A) Hepatic mRNA levels of Cyp8b1 in  L-FoxO1,3,4 −/−  and L-FoxO1,3,4 +/+  mice and in C57BL/6 mice treated with either shChREBP or scrambled shRNA, infused with  S4048 o
FIg. 3. ChREBP does not directly regulate hepatic Cyp8b1 transcription. (A) Schematic presentation of putative consensus and  alternative ChREBP response elements within the murine Cyp8b1 promoter
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