Activités anti-biofilm de Lactobacillus vis-à-vis de Klebsiella Pneumoniae

Texte intégral

(1)Activités anti-biofilm de Lactobacillus vis-à-vis de Klebsiella Pneumoniae Rosyne Lagrafeuille. To cite this version: Rosyne Lagrafeuille. Activités anti-biofilm de Lactobacillus vis-à-vis de Klebsiella Pneumoniae. Médecine humaine et pathologie. Université d’Auvergne - Clermont-Ferrand I, 2016. Français. �NNT : 2016CLF1PP03�. �tel-01661354v2�. HAL Id: tel-01661354 https://tel.archives-ouvertes.fr/tel-01661354v2 Submitted on 13 Dec 2017. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

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(5) 5(0(5&,(0(176 Cette thèse a été réalisée grâce à un financement de la Région Auvergne, que je remercie grandement. Je remercie Muriel Mercier-Bonin, Muriel Thomas ainsi que Marie-José Butel de m’avoir fait l’honneur d’évaluer ce travail. Je remercie également Nicolas Barnich et Adrien Nivoliez d’avoir accepté de participer à mon jury de thèse. Au terme de ce doctorat, je tiens à remercier sincèrement Christiane Forestier de m’avoir accueillie au sein de son équipe et de m’avoir guidée dans la réalisation de cette thèse. Votre disponibilité, vos précieux conseils, mais aussi votre rire communicatif et vos qualités humaines font de ce laboratoire un environnement de travail et de partage chaleureux. Merci de votre confiance et de m’avoir permis de découvrir le monde de la recherche à vos côtés. Je remercie vivement Sylvie Miquel de m’avoir aidée dans l’accomplissement de cette thèse. Merci de m’avoir transmis toutes tes connaissances techniques et scientifiques et fait part de ton expérience. Tu as toujours su prendre le temps de m’épauler, de me conseiller et surtout de répondre à mes innombrables questions, parfois redondantes !!! Enfin, un immense merci pour ton soutien, plus particulièrement pour la bienveillance que tu as eue à mon égard dans les moments plus difficiles. Un grand merci à Marjolaine Vareille-Delarbre pour sa gentillesse ainsi que pour sa contribution à ces travaux de recherche notamment au versant immunologique. Je tiens à remercier Annick Bernalier-Donadille et Elisabeth Billard d’avoir lu et évalué mon travail en acceptant de faire partie de mes comités de thèse. Je remercie également toutes les personnes ayant contribué de près ou de loin à ce travail, en particulier les partenaires industriels investis dans ce projet de thèse ; les sociétés biose, BioFilm Control et Biovitis pour ces nombreuses réunions qui m’ont aidé à compléter et valoriser mes travaux. Merci également à Philippe Langella et Florian Chain de m’avoir aimablement envoyé des surnageants de Lactobacillus. Merci à Christelle Blavignac pour son expertise en microscopie électronique à balayage ainsi qu’à Emmanuelle Bille et Xavier Nassif pour l’accueil au sein de leur laboratoire le temps d’une formation. J’exprime ma profonde gratitude envers mes collègues de laboratoire, tous ceux aux côtés de qui j’ai eu la chance de travailler et passer de très bonnes soirées extra-professionelles. Je tiens à souligner vos aptitudes pâtissières et par conséquent toutes ces occasions non manquées de céder à la gourmandise… que dis-je, de perfectionner notre palais ! Un immense merci plus particulièrement à : Cyril Guilhen, alias « Guilhen », pour tous les moments passés ensemble qui ne sont pas étrangers à cette complicité qu’est devenue amitié. Acolyte d’open space et de manips durant ces journées sans fin au labo, mais aussi de mots croisés et surtout de plaisanteries, on forme une sacrée équipe LIMOUSINE !!! Je te lègue le devoir qui m’incombait chaque matin, celui de prendre le journal, car je ne serai bientôt plus là pour mener cet impératif à bien !.

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