• Aucun résultat trouvé

Impact of a maternal diabetes on embryonic DNA methylation in rabbit blastocyst

N/A
N/A
Protected

Academic year: 2021

Partager "Impact of a maternal diabetes on embryonic DNA methylation in rabbit blastocyst"

Copied!
2
0
0

Texte intégral

(1)

HAL Id: hal-01606710

https://hal.archives-ouvertes.fr/hal-01606710

Submitted on 2 Jun 2020

HAL is a multi-disciplinary open access

archive for the deposit and dissemination of

sci-entific research documents, whether they are

pub-lished or not. The documents may come from

teaching and research institutions in France or

abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est

destinée au dépôt et à la diffusion de documents

scientifiques de niveau recherche, publiés ou non,

émanant des établissements d’enseignement et de

recherche français ou étrangers, des laboratoires

publics ou privés.

Distributed under a Creative Commons Attribution - ShareAlike| 4.0 International

License

Impact of a maternal diabetes on embryonic DNA

methylation in rabbit blastocyst

K. J. Grybel, Eugénie Canon, J. Knelangen, D. Kradolfer, M. Pendzialek, M.

Schindler, J. Guerke, T. Blachere, Murielle Godet, R. Obeid, et al.

To cite this version:

K. J. Grybel, Eugénie Canon, J. Knelangen, D. Kradolfer, M. Pendzialek, et al.. Impact of a maternal

diabetes on embryonic DNA methylation in rabbit blastocyst. 50. Annual Conference of Physiology

and Pathology of Reproduction, Deutsche Veterinärmedizinische Gesellschaft. DEU., 2017, Munich,

Germany. 64 p., �10.1111/rda.12909�. �hal-01606710�

(2)

ՊՍՊ

|

ՊƑƐ ABSTRACTS

ƓƒՊ

ŇՊlr-1|o=-l-|;um-Ѵ7b-0;|;vom

;l0u‹omb1 l;|_‹Ѵ-ঞombmu-00b|0Ѵ-v|o1‹v|

bmY†vv;bm;vlু‚;uѴb1_;m b-0;|;vl;ѴѴb|†v

-†=7b; Ŋ;|_‹Ѵb;u†m]7;v l0u‹ov0;bl

-mbm1_;m

u‹0;Ѵ1ĸ -mom2ĸm;Ѵ-m];m1ĸ u-7oѴ=;u3;

;m7Œb-Ѵ;h1; M Schindler1ĸুuh;1ĸ$Ѵ-1_࣏u;Ɠ;

M GodetƓ; R Obeid5; S Ulbrich3ĸ bv1_;u1ĸ( †u-m|_om2;

-ˆ-uu;|;"-m|ov1

1 ;r-u|l;m|o=m-|ol‹-m7;ѲѲboѲo]‹Ķ-uࢼm†|_;u&mbˆ;uvb|‹ -1†Ѳ|‹o= ;7b1bm;Ķ-ѲѲ;Ķ;ul-m‹ķ2!Ķ&!Ķ ;r-u|l;m|o=|_;!;ruo7†1ࢼˆ;boѲo]‹Ķ o†‹ň;mňov-vĶ u-m1;ķ3mvࢼ|†|;o=]ub1†Ѳ|†u-Ѳ"1b;m1;vĶ,ࣟub1_Ķ"‰b|Œ;uѲ-m7ķ 4"|;lň1;ѲѲ-m7u-bm!;v;-u1_mvࢼ|†|;ĶuomĶ u-m1;-m7&mbˆ;uvb|‹o=‹omĶ &mbˆ;uvb|ߪ‹omĶ‹omĶ u-m1;ķ5Department of Clinical Chemistry, University ovrb|-Ѳo=|_;"--uѲ-m7Ķol0†u]Ķ;ul-m‹ m;-uѴ‹ru;]m-m1‹l-|;um-Ѵ7b-0;|;vѴ;-7v|o7;Ѵ-‹bm;l0u‹o7;ˆ;Ѵ-orl;m|-m71_-m];vbmm†|ubঞom-Ѵ-m7_oulom-Ѵvb]m-Ѵvo=|_;†|;ubm; ;mˆbuoml;m|ĺ$_;1†uu;m|v|†7‹=o1†v;vom1omv;t†;m1;vo=l-|;um-Ѵ 7b-0;|;vom;l0u‹omb1ঞvv†;=oul-ঞom-m7b|v l;|_‹Ѵ-ঞomĺ $_;u;=ou;‰;bmˆ;vঞ]-|;7|_;;Šru;vvbom-m7ruolo|;ul;|_‹Ѵ-ঞom o= ;rb0Ѵ-v| Ѵbm;-]; vr;1bC;u 1|Ɠ bm ѵ7-‹ oѴ7 u-00b| 0Ѵ-v|o1‹v|v -| ;-uѴ‹ ]-v|u†Ѵ-ঞom v|-];ĺ $_; ;Šru;vvbom o= 1|Ɠ ‰-v _b]_;u bm ;rb-0Ѵ-v|o=7b-0;ঞ10Ѵ-v|o1‹v|vķ-11olr-mb;70‹†ru;]†Ѵ-ঞomo=-mo] -m7 "oŠƑĺ "r;1bC1 l;|_‹Ѵ-ঞom o= |_; &Ɣ Ɛ Ő1|Ɠő ruolo|;u u;]bom‰-vbmˆ;vঞ]-|;70‹0bv†Ѵr_b|;v;t†;m1bm]ĺ$_;1|Ɠruolo|;u ‰-v_‹rol;|_‹Ѵ-|;7bm_‹ro0Ѵ-v|v-m7|uor_o0Ѵ-v|vo=7b-0;ঞ1u-0-0b|vķblrѴ‹bm]-Ѵvo-l-uho=7;Ѵ-‹bm7b@;u;mঞ-ঞomĺ$_;]Ѵo0-Ѵ  l;|_‹Ѵ-ঞomo=l-Ѵ;-m7=;l-Ѵ;0Ѵ-v|o1‹v|v=uol7b-0;ঞ1-m7_;-Ѵ|_‹ u-00b|v ‰-v ;Š-lbm;7ķ ;lrѴo‹bm] ;l0u‹o0Ѵ-v| -m7 |uor_o0Ѵ-v| ঞv-v†; v;r-u-|;Ѵ‹ķ †vbm] &lbmol;|ub1 ;|_‹Ѵ-ঞom vv-‹ Ő&őĺ o vb]mbC1-m| 1_-m];v bm ]Ѵo0-Ѵ  l;|_‹Ѵ-ঞom ‰;u; o0v;uˆ;7ĺ †u|_;ulou;‰;ˆ;ubC;7|_-|1om1;m|u-ঞomvo=l;|_‹Ѵ]uo†r7omou "Ŋ-7;mov‹Ѵ l;|_bombm; Ő"ő -m7 |_; ruo7†1| o= |_; l;|_‹Ѵ-ঞom u;-1ঞomv "Ŋ-7;mov‹Ѵ_olo1‹v|;bm; Ő"ő ‰;u; 1_-m];7 bm 7b-0;ঞ1 ru;]m-m1‹ĺ"-m7"‰;u;l;-v†u;70‹†v;o=-lo7bC;7Ѵbt†b7 1_uol-|o]u-r_‹ŋ|-m7;ll-vvvr;1|uol;|u‹bmu-00b|0Ѵoo7rѴ-vl- 1oѴѴ;1|;7-||_;7-‹ѵrov|Ŋ1ob|†lĺ†u7-|-v_o‰;7|_-|l-|;um-Ѵ 7b-0;|;vl;ѴѴb|†v-@;1|v|_;1|Ɠruolo|;ul;|_‹Ѵ-ঞombm-vr;1bC1 ‰-‹ ‰b|_ 1omv;t†;m1;v =ou 1|Ɠ ];m; |u-mv1ubrঞom -m7 ;l0u‹o 7;ˆ;Ѵorl;m|ĺ Ѵ|;u-ঞom o= 1|Ɠ l;|_‹Ѵ-ঞom ‰-v mo| 1-†v;7 0‹ ]Ѵo0-Ѵl;|_‹Ѵ-ঞom1_-m];vĺ

ƓƓՊ

ŇՊ&uovr;ulb-bm-m m|Ѵ;0†1_;uo†m|-bm

o]‰b|_;1|orb1†u;|;uvŌ-1-v;u;rou|

&uovr;ulb;0;b;bm;l m|Ѵ;0†1_;u";mm;m_†m7

lb|;h|orbv1_;m&u;|;u;mŌ bm -ѴѴ0;ub1_|

!ুmŒ;ѴŊr;ѴƐķƑĸ)oѴ=ƐķƑĸ-†l;bv|;uƐķƑĸ-1_2; "†m];u0ু_Ѵ;u2

1&mb|=ou!;ruo7†1ࢼˆ;;7b1bm;o=Ѳbmb1vķ2Small Animal Clinic, University of (;|;ubm-u‹;7b1bm;-mmoˆ;uĶ o†m7-ࢼomĶ-mmoˆ;uĶ;ul-m‹ &uovr;ulb-ņ&"l-‹u;v†Ѵ|=uolu;|-u7;71Ѵov†u;o=|_;†ubm-u‹0Ѵ-7- 7;um;1h7†ubm]v;l;m;lbvvbom7†;|oѴo1-ѴbmY-ll-ঞomoubmv†=-C1b;m|ŎŊ-7u;m;u]b1vঞl†Ѵ-ঞomo=|_;vloo|_l†v1Ѵ;Ѵ-‹;uvĺ‹|_bv †ubm;r-vv;v|_;0Ѵ-77;um;1h‰_;mru;Ŋv;1u;ঞom-m7|_;vr;ulub1_ =u-1ঞom-u;u;-1_bm]|_;r;Ѵˆb1†u;|_u-ĺm|_;ru;v;m|1-v;&"bvv†v-r;1|;7|o0;|_;u;v†Ѵ|o=-0bѴ-|;u-Ѵ;1|orb1†u;|;uŐ &őķ-1om];mb|-Ѵ l-Ѵ=oul-ঞomķ‰b|_|_;†u;|;u-ѴoubC1;|;ulbm-ঞm]bm|u-ˆ;vb1-ѴѴ‹m;-u |_;0Ѵ-77;um;1hou;Š|u-ˆ;vb1-ѴѴ‹-||_;ruov|-|;ķ7;=;u;m|7†1|ķou †u;|_u-ĺ -v; u;rou|Ĺ  ƓŊ‹;-uŊoѴ7 m|Ѵ;0†1_;u o†m|-bm o] ‰-v ru;v;m|;7 =ou 0u;;7bm] vo†m7m;vv ;ˆ-Ѵ†-ঞom 7†; |o -m †mv†11;vv-=†Ѵl-ঞm]Ɣlom|_v-]oĺ||_;-];o=Ƒ‹;-uv-m-0moul-Ѵ1o†uv; o=0o|_†u;|;uvbm|_;-u;-o=|_;0Ѵ-77;um;1h_-70;;m7b-]mov;7 vomo]u-r_b1-ѴѴ‹ĺv|_;Cm7bm]‰-vmo|1Ѵ-vvbC;7-vv;ubo†vķ|_;7o] _-7 0;;m -rruoˆ;7 =ou 0u;;7bm]ĺ $_; 1†uu;m| -m7uoѴo]b1-Ѵ ;Š-lb-m-ঞom u;ˆ;-Ѵ;7 0o|_ |;v|;v -m7 ;rb7b7‹lb7;v o= -7;t†-|; vbŒ; -m7 v_-r;ĺ$_;1oѴѴ;1|;7;f-1†Ѵ-|;v_o‰;7moul-ѴˆoѴ†l;-m7|o|-Ѵvr;ul 1o†m|ķ0†|v;ˆ;u;7;C1b;m1b;vbmvr;ulloঞѴb|‹ķrѴ-vl--m7-1uovol; l;l0u-m;bm|;]ub|‹-m7vr;ullour_oѴo]‹ĺ$_;lov|v|ubhbm]l-1-uov1orb1 Cm7bm] ‰-v - ‹;ѴѴo‰bv_ -rr;-u-m1; v_o‰bm] 1omঞm†o†vѴ‹ bm1u;-vbm]bm|;mvb|‹bm|_;‰-|;u‹ruov|-ঞ1v;1u;ঞomĺ7o†u-m7rŊ ˆ-Ѵ†;u;ˆ;-Ѵ;7-7lbŠ|†u;o=†ubm;ĺu;r;-|†Ѵ|u-vo†m7;Š-lbm-ঞom 1omCul;7-0bѴ-|;u-Ѵbm|u-l†u-Ѵ &;m|;ubm]|_;†ubm-u‹0Ѵ-77;u-0o†| Ɛ1l1u-mb-Ѵo=|_;ˆ;vb1oŊ†u;|_u-Ѵ|u-mvbঞom‰b|_|_;or;mbm]robm|-bm] 1-†7-ѴѴ‹ĺ $_bv Cm7Ɛ1l1u-mb-Ѵo=|_;ˆ;vb1oŊ†u;|_u-Ѵ|u-mvbঞom‰b|_|_;or;mbm]robm|-bm] l-‹ mo| r;u v; bm7b1-|; - 1-†v-Ѵ 1omm;1-ঞom0;|‰;;m &-m7&"ĺ;ˆ;u|_;Ѵ;vv|_;Ѵ-‚;ul-‹0;-=†m1ঞom-Ѵ bm7b1-|ouo=-†ubm;Ѵ;-h-];rovvb0Ѵ‹;Šbvঞm]-v-77bঞom-Ѵ1om];mb|-Ѵ -0moul-Ѵb|‹bm|_;1-†7-Ѵˆ;vb1-Ѵņ1u-mb-Ѵ†u;|_u-Ѵ-u;-ĺ

ƓƔՊ

ŇՊ -1|ouv-@;1ঞm]v;l;m;ˆ-Ѵ†-ঞomo=

m-ঞˆ;-m7=uoŒ;mŊ|_-‰;7]o-|v;l;m

bmY†vv=-h|ou;m-†=vr;ul-|oѴo]bv1_;

&m|;uv†1_†m]v;u];0mbvv;†m77;m u=oѴ]7;u

u‹ohomv;uˆb;u†m]ˆom,b;];mvr;ul--_m1; A Wehrend2

1Ѳbmb1=ououv;vĶ;7b1bm;-m7!;ruo7†1ࢼomĶ&†mb1_Ķ;ul-m‹ķ2Clinic for 0v|;|ub1vĶ‹m;1oѲo]‹-m7m7uoѲo]‹o=-u];-m7"l-ѲѲmbl-Ѳv‰b|_l0†Ѳ-|ou‹ ";uˆb1;Ķ&b;vv;mĶ;ul-m‹ -u-l;|;uv1oѴѴ;1|;77†ubm]v;l;m;ˆ-Ѵ†-ঞom-u;|_;0-vbv|o;v|-0-Ѵbv_|_;v†b|-0bѴb|‹o=-m;f-1†Ѵ-|;ĺ$_;u;=ou;ķ|_;1om7bঞomvl†v|0; h;r|-v1omv|-m|-vrovvb0Ѵ;ĺ$_;-blo=|_bvv|†7‹‰-v|o;ˆ-Ѵ†-|; rovvb0Ѵ;=-1|ouv-@;1ঞm]v;l;m-m-Ѵ‹vbvo=m-ঞˆ;-m7=uoŒ;mŊ|_-‰;7 ]o-| v;l;mĺ  |o|-Ѵ o= ƑƏ ;f-1†Ѵ-|;v =uol Ɣ _;-Ѵ|_‹ r;-1o1h ]o-| 0†1hv ‰;u; o0|-bm;7 †vbm] -m -uঞC1b-Ѵ ˆ-]bm-ĺ [;u - l-1uov1orb1 ;ˆ-Ѵ†-ঞom Ƒ -Ѵbt†o|v ‰;u; -vv;vv;7 -| 7b@;u;m| _-m7Ѵbm] |;lr;u--|†u;vŐƑƏ-m7ƒƕŦő-m7ঞl;robm|vŐ$őŐƒķƐƏķƐƔ-m7ƒƏlbmĺ-[;u 1oѴѴ;1ঞomőĺ $_; r o= ;-1_ v-lrѴ; ‰-v ;ˆ-Ѵ†-|;7 ‰b|_ bm7b1-|ouŊ r-r;u ;ˆ;u‹ ƐƏlbmĺ =ou Ɛ_ĺ ;mvb|‹ -m7 ruo]u;vvbˆ; loঞѴb|‹ Őő

‰;u;-vv;vv;7†vbm]1olr†|;u-vvbv|;7vr;ul-m-Ѵ‹vbvŐm7uo(bvbom®ķ

bmb|ু0ķ;ul-m‹őĺ ˆ-Ѵ†-ঞomo=v;l;mˆb-0bѴb|‹‰-vr;u=oul;7†vbm] 0uolor_;moѴŊmb]uovbm;v|-bmbm]ĺ ou1u‹oru;v;uˆ-ঞomķ-1oll;u1b-Ѵ

Références

Documents relatifs

To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed

Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à

Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine

En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages

Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur

A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated

The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide

Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to