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Proximal Protein Interaction Landscape of RAS Paralogs

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Academic year: 2021

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Figure 1. The RAS interactome by BioID. (A) The network of RAS protein–protein interactions  includes shared and specific interactors (prey) for the three indicated RAS paralogs
Figure 2. Comparison of the RAS networks identified with BioID and IP-MS. (A) Venn diagrams of  the shared and specific interactors identified by IP-MS and BioID, as well as the overlap with RAS  interactors referenced in the BioGRID, MINT and HPRD databas
Figure 3. Cellular localization of the RAS proximal interactors identified by BioID: (left) cell mapping  of each RAS interactor determined by Gene Ontology analysis focused on cellular components; and  (right) associated p values calculated for each cellu
Figure 4. Specific pathways of the RAS proximal interactors: (A) The KEGG pathway analysis  identified SNARE interaction in vesicular transport (hsa04130), tight junctions (hsa04530), oxidative  phosphorylation (hsa00190) and cell adhesion molecules (hsa04
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