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Intensive Care Med (2007) 33:1854

DOI 10.1007/s00134-007-0796-7

C O R R E S P O N D E N C E

Marc Feissel

Jean Louis Teboul

Karim Bendjelid

Reply to the comment

by Drs. Cannesson et al.

Accepted: 3 July 2007 Published online: 28 July 2007 © Springer-Verlag 2007

This reply refers to the comment available at: http://dx.doi.org/10.1007/s00134-007-0795-8.

We thank Drs. Cannesson et al. for

their kind comments regarding our

contribution [1]. We fully agree with

these authors that pulse oximeters

use digital signal processing to make

accurate measurements in clinical

conditions that were otherwise

im-possible (e. g., patient motion, low

perfusion, electrical interference).

The highly processed waveform is the

resultant of an enhancement of the

input signal through a method called

filtering which consists of some

trans-formation of a number of surrounding

samples around the current sample of

the input or output signal. Therefore

it is of major importance to be as

precise as possible regarding the way

in which the signal is recorded and

analyzed since the plethysmographic

waveform may have an additional

nonrespiratory, low-frequency

fluctu-ation (Mayer waves) [2]. Cannesson

et al. also emphasize that the signal

quality index and the perfusion index

both impact the waveform [3, 4]. The

concerns underlined by the authors

regarding the influence of

vasomo-tor tone on the plethysmographic

waveform specially in patients

re-ceiving norepinephrine are addressed

in our manuscript. Finally, one of

the authors of our study has already

considered that the way in which the

data are recorded and analyzed should

be standardized in order to isolate

and quantify the required piece of

information [5].

References

1. Feissel M, Teboul JL, Merlani P, Badie J, Faller JP, Bendjelid K (2007) Plethysmographic dynamic indices predict fluid responsive-ness in septic ventilated patients. Intensive Care Med 33:993–999 2. Annane D, Baudrie V, Blanc AS,

Laude D, Raphael JC, Elghozi JL (1999) Short-term variability of blood pressure and heart rate in Guillain-Barre syndrome without respiratory failure. Clin Sci (Lond) 96:613–621

3. Lima AP, Beelen P, Bakker J (2002) Use of a peripheral perfusion index derived from the pulse oximetry signal as a noninvasive indicator of perfusion. Crit Care Med 30:1210–1213

4. Feissel M, Badie J, Merlani PG, Faller JP, Bendjelid K (2005) Pre-ejection period variations predict the fluid responsiveness of septic ventilated patients. Crit Care Med 33:2534–2539 5. Monnet X, Lamia B, Teboul JL (2005) Pulse oximeter as a sensor of fluid re-sponsiveness: do we have our finger on the best solution? Crit Care 9:429–430

M. Feissel

Centre Hospitalier, Intensive Care Unit, Belfort, France

J. L. Teboul

Paris Sud Medical School, Réanimation Médicale, Bicêtre Hospital,

Le Kremlin Bicêtre, France K. Bendjelid (u)

Geneva University Hospitals, Intensive Care Unit, Department of Anesthesiology, Pharmacology and Intensive Care, 1211 Geneva 14, Switzerland e-mail: karim.bendjelid@hcuge.ch Tel.: +41-22-3827460

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