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tel-00011814, version 1 - 8 Mar 2006

tel-00011814, version 1 - 8 Mar 2006

tel-00011814, version 1 - 8 Mar 2006

„ 5

tel-00011814, version 1 - 8 Mar 2006

tel-00011814, version 1 - 8 Mar 2006

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tel-00011814, version 1 - 8 Mar 2006

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tel-00011814, version 1 - 8 Mar 2006

tel-00011814, version 1 - 8 Mar 2006

0 50 100 150 200 250 300

heart soleus white gastroc EDL heart soleus white gastroc EDL

Control K/O STOP pr ote in

tel-00011814, version 1 - 8 Mar 2006

0 2 4 6 8 10 12 14 16

V ( n m o lO 2 /m in /m g d w )

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WT K/O

tel-00011814, version 1 - 8 Mar 2006

tel-00011814, version 1 - 8 Mar 2006

tel-00011814, version 1 - 8 Mar 2006

tel-00011814, version 1 - 8 Mar 2006

tel-00011814, version 1 - 8 Mar 2006

0 50 100 150 200 250 300 350

a p p a re n t K m f o r e x o g e n o u s A D P ( µ M )

skinned control skinned colch 10 µM skinned colch 10 µM ghost control ghost colch 10 µM ghost colch 10 µM

tel-00011814, version 1 - 8 Mar 2006

S H E

R T R T R T

Genes of interest

S

H S

common pool of genes characteristic for heart and

subtracted against

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Subtraction against driver cDNA SHE Isolation of total

RNA pools

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tester tester driver

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subtracted heart

cDNA library ^{S E}

Subtracted soleus cDNA library

tel-00011814, version 1 - 8 Mar 2006

tel-00011814, version 1 - 8 Mar 2006

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