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Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities

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Academic year: 2021

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Figure 1. Domains II and IV of the extracellular a-chain of LRP-1 are required to bind and promote TIMP-1 endocytosis in CHO cells.
Table 1. Kinetics of TIMP-1 binding to LRP-1 domains II and IV.
Figure 2. Endogenous TIMP-1 interacts with LRP-1 in cortical neurons. A. Cortical neurons from mouse embryos were plated onto poly-L- poly-L-lysine-coated coverslips for 24 h at 37uC, fixed, washed and stained with anti-LRP1 antibody (Alexa Fluor 488, gree
Figure 3. TIMP-1 binding to LRP-1 reduces neurite length. A. Cortical neurons from mouse embryos were cultured for 24 h on poly-L-lysine- poly-L-lysine-coated coverslips and then treated for 30 min with TIMP-1 (10 nM), RAP (500 nM), blocking LRP-1 polyclon

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