HAL Id: inserm-00382262
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Farnesyltransferase inhibitor R115777 inhibits cell
growth and induces apoptosis in mantle cell lymphoma.
Delphine Rolland, Valérie Camara-Clayette, Aurélie Barbarat, Gilles Salles,
Bertrand Coiffier, Vincent Ribrag, Catherine Thieblemont
To cite this version:
Delphine Rolland, Valérie Camara-Clayette, Aurélie Barbarat, Gilles Salles, Bertrand Coiffier, et al.. Farnesyltransferase inhibitor R115777 inhibits cell growth and induces apoptosis in mantle cell lymphoma.. Cancer Chemotherapy and Pharmacology, Springer Verlag, 2008, 61 (5), pp.855-63. �10.1007/s00280-007-0543-3�. �inserm-00382262�
Table 1 R115777 cytostatic concentrations (C) R115776 R115777 IC50 of R115777 Cell lines C (nM) Relative cell count (%) Standard deviation Relative cell count (%) Standard deviation Median (µM) Standard deviation Granta 8 108 10 57 6 2,7 1,5 NCEB 15 72 5 40 9 15 3,4 REC 2 83 8 48 4 0,08 0,02 UPN1 2 88 7 47 3 13,8 3,9 SKMEL 5 nd nd nd nd nd 12 3,9
