• Aucun résultat trouvé

Reply to the Letter to the Editor entitled: ‘Hsp 27 as a potential preneoplastic marker in patients with chronic kidney disease (CKD)

N/A
N/A
Protected

Academic year: 2022

Partager "Reply to the Letter to the Editor entitled: ‘Hsp 27 as a potential preneoplastic marker in patients with chronic kidney disease (CKD)"

Copied!
2
0
0

Texte intégral

(1)

Article

Reference

Reply to the Letter to the Editor entitled: ‘Hsp 27 as a potential preneoplastic marker in patients with chronic kidney disease (CKD)

GARCÍA-GARCÍA, Virginia, et al.

GARCÍA-GARCÍA, Virginia, et al . Reply to the Letter to the Editor entitled: ‘Hsp 27 as a potential preneoplastic marker in patients with chronic kidney disease (CKD). Oral Diseases , 2013, vol.

19, no. 3, p. 320-320

DOI : 10.1111/odi.12029 PMID : 23114194

Available at:

http://archive-ouverte.unige.ch/unige:90731

Disclaimer: layout of this document may differ from the published version.

1 / 1

(2)

LETTER TO THE EDITOR

Reply to the Letter to the Editor entitled: ‘Hsp 27 as a potential preneoplastic marker in patients with chronic kidney disease (CKD)’

Dear Editor,

We would like to send our thanks to the authors of the Letter to the Editor entitled ‘Hsp 27 as a potential preneo- plastic marker in patients with chronic kidney disease (CKD)’ for their interest in our article, and to Oral Dis- eases for allowing us to express our opinion. The main common factor between oral lichen planus (OLP) and CKD is a protracted chronic evolution, during which vari- ous changes occur and risk factors may appear. The main progressive changes occurring in CKD include the action of uraemic toxins, inflammation, increase in apoptosis and an impairment of immunity (Musial and Zwolinska, 2011), whereas in OLP, they consist, mainly, in epithelial atrophy, hyperkeratosis andfibrosis of the corium. In both diseases, there is an increased possibility for malignant transformation in the late stages (Stewart et al, 2009; Gar- cia-Garciaet al, 2012).

The authors suggest that among other co-morbidities, OLP could be present in a part of CKD patients, espe- cially after renal transplantation on immunosuppressive therapy, a notion still unknown to stomatologists and oral pathologists, which should need a large cooperative study for verification. A lot of mainly drug-induced oral liche- noid manifestations have been described, and it is often very difficult to distinguish between them and true OLP.

The presence of lichen-planus-like diseases in CKD patients has been described (Potter and Wilson, 1979).

An uncommon complication of uraemia that may occur as a result of advanced renal failure is uraemic stomatitis (Antoniades et al, 2006). Such disorder, which is attrib- uted to a toxic effect of urea with formation of urea com- pounds, is in its main form characterized by a painful white tongue and a more or less white oral mucosa, some- times clinically mimicking OLP, but the histological features of lichen planus are always absent.

A protective role of both the intracellular and extracel- lular forms of HSP27 has been suggested (Van Why and Siegel, 1998). It is not clear yet whether the extracellular expression and intracellular expression of HSPs play the same role in the sense of cytoprotection or deleterious effects in OLP. A defending role of Hsp70 has been detected in saliva as it is involved in both innate and acquired immune activation (Fabian et al, 2012). Despite the fact that OLP does not involve the salivary glands, considering the saliva as a transport fluid, an analysis of

the possible correlation between the intracellular and extracellular expression in saliva of HSP27 in the different stages of OLP would be interesting.

Author contributions

All the authors have contributed equally to this manu- script. Virginia García, Roger Küffer and Tommaso Lom- bardi have redacted the letter while Antonio Bascones and Carla Martinelly have reviewed it and look for papers related with the issue.

Virginia García-García1, Antonio Bascones-Martínez1, Carla P. Martinelli-Kläy2, Roger Küffer2and Tommaso Lombardi2

1Oral Medicine, Dental School (UCM), Madrid, Spain,

2School of Dental Medicine, Laboratory of Oral and Max- illofacial Pathology, Division of Stomatology and Oral Surgery, Geneva, Switzerland E-mail: virginiaborj@hotmail.com

References

Antoniades DZ, Markopoulos AK, Andreadis D, Balaskas I, Patrikalou E, Grekas D (2006). Ulcerative uremic stomatitis associated with untreated chronic renal failure: report of a case and review of the literature.Oral Surg Oral Med Oral Pathol Oral Radiol Endod101: 608–613.

Fabian TK, Hermann P, Beck A, Fejerdy P, Fabian G (2012).

Salivary defense proteins: their network and role in innate and acquired oral immunity.Int J Mol Sci13: 4295–4320.

Garcia-Garcia V, Bascones-Martinez A, Garcia-Kass A et al (2012). Analysis of the expression of heat-shock protein 27 in patients with oral lichen planus. Oral Dis [Epub ahead of print].

Musial K, Zwolinska D (2011). Heat shock proteins in chronic kidney disease.Pediatr Nephrol26: 1031–1037.

Potter JL, Wilson NH (1979). A dental survey of renal dialysis patients.Public Health93: 153–156.

Stewart JH, Vajdic CM, van Leeuwen MT et al (2009). The pattern of excess cancer in dialysis and transplantation.

Nephrol Dial Transplant24: 3225–3231.

Van Why SK, Siegel NJ (1998). Heat shock proteins in renal injury and recovery. Curr Opin Nephrol Hypertens 7:

407–412.

Oral Diseases (2013) 19, 320 doi:10.1111/odi.12029

©2012 John Wiley & Sons A/S All rights reserved

www.wiley.com

Références

Documents relatifs

S'ouvrir à la pensée pour mieux s'émanciper Des certitudes apprises et non vérifiées Le long cheminement cherche la vérité De l'intuition suprême à la fin révélée Et

Le taureau entravé des pattes de derrière Mithra va le porter pour son heure dernière Un corbeau dans la grotte envoyé du soleil Assiste au sacrifice lui donnant des conseils

[r]

Coupez et coller le prochain object qui devrait apparaitre dans la suite1. `

Si nous considérons les différentes espèces d'Ecteinascidia décrites nous constatons que la forme des siphons est très variable : Ils peuvent être non lobés

Title Page Abstract Introduction Conclusions References Tables Figures J I J I Back Close.. Full Screen

Même si la phrase ne comporte qu’un seul verbe conjugué, sa longueur peut varier selon l’enrichissement donné aux éléments de base que sont le thème, le propos et le complément

Revenons sur le contenu de nos chère terres bleus, ces petites merveilles peuvent contenir de vaste paysage allant de quelques mètres à <!>, les mini-vers(mini- univers)