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Comparison of the zebrafish embryo toxicity assay and the general and behavioral embryo toxicity assay as new approach methods for chemical screening

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Academic year: 2021

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Table 1. Groupings of chemicals tested in this study. Chemicals are grouped by use and span a wide range of molecular weights and Log p values
Table 2. Phenotypes and phenotypic groupings used for manual scoring of larvae at 120 h post fertilization (hpf) for both the Zebrafish Embryo Toxicity (ZET) and General and Behavioral Toxicity (GBT) assays.
Figure 1. Correlation analysis between assays. The correlation between EC 50 (A) and LC 50 (B) values was determined between the ZET assay (x-axis) and GBT assay (y-axis)
Table 4. Lowest observed effect concentrations (LOEC) for each compound based on the phenotypic observations in the ZET/GBT assays and any change in behaviour for the GBT assay
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