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Assessing the Impact of Differential Genotyping Errors on Rare Variant Tests of Association

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Academic year: 2021

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Figure 1. Type I error rate when error rate in controls is 0.10%. The observed type I error rate, averaged across all simulation settings, for each of the five rare variant tests (CMC, WS, PR, CMAT and SKAT)
Figure 2. Type I error rate when error rate in controls is 1%. The observed type I error rate, averaged across all simulation settings, for each of the five rare variant tests (CMC, WS, PR, CMAT and SKAT)
Figure 5. Type I error rate variability by error model for a gene with 8 SNVs. Figure 5 considers a gene containing 8 rare variants
Figure 7. Type I error rate variability across additional error models: a gene with 8 SNVs
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