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Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge

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Academic year: 2021

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Table 1. STC datasets
Figure 4A and B show the mean Pr p and Pr g for all partici- partici-pants plotted against S p and S g, respectively, based on activation in stimuli
Figure 5D reflects a hierarchical clustering of genes that were present in at least 4 of the top 25 best-predicted gene sets (49 genes among 19 gene sets), as well as the frequency they were found as part of the CORE enrichment for that gene set
Fig. 5. Best translated gene sets representative of different pathways. (A) Histogram of the percentage of active gene set/stimulus pairs [560 pairs from 6396 (246 gene sets 26 stimuli)] correctly predicted by N teams

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