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Are integrins still practicable targets for anti-cancer therapy?

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Table 1. Overview of integrins expressed in cancer cells and the cells of the tumor microenvironment.
Table 1. Cont. α V β 1 + ++ ++ ++ α L β 2 +++ α M β 2 +++ αXβ2 +++ α D β 2 +++ α V β 3 + +++ +++ ++ +++ α iib β 3 + Platelets α 6 β 4 +++ ++ αVβ5 + +++ +++ ++ α V β 6 + +++ ++ α 4 β 7 + +++ α E β 7 +++ αVβ8 + ++ +++ ++ ++
Figure 1. Integrin-dependent functions relevant to cancer. Integrins have been implicated in mediating several hallmarks of cancer, including cancer cell proliferation, dormancy, survival, stemness, metabolic adaptation, and metastat
Table 2. Selected clinical trials of agents targeting integrins. Non-exhaustive listing of the recent most important clinical studies with integrin inhibitors and their salient features and results).
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