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A microfluidic device for both on-chip dialysis protein crystallization and in situ X-ray diffraction

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Academic year: 2021

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Fig. 2 NOA 81 microfluidic chips embedding an RC dialysis membrane for the on-chip crystallization of proteins and in situ X-ray measurements.
Fig. 5 Crystals of IspE ( ∼ 10 mg mL −1 ) grown on-chip via the micro-dialysis method after a) 6 days, b) 19 days and c) 50 days from the onset of the experiment
Fig. 5 shows the nucleation and growth of IspE crystals at dif- dif-ferent time intervals from the onset of the experiment
Fig. 6 Multiple isomorphous single a) IspE and b) insulin crystals grown on-chip via the micro-dialysis method, used for collecting in situ X-ray dif- dif-fraction data
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