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Zebrafish xenografts as a fast screening platform for bevacizumab cancer therapy

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Academic year: 2021

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Fig. 2 Zebra fi sh xenografts reveal different tumor responses to bevacizumab. Human cancer cell lines (Hs578T, MDA-MB-468, HCT116, SW620 or HT29) were injected into the PVS of 2 dpf Tg( fl i1:eGFP) zebra fi sh larvae
Fig. 3 Bevacizumab reduces angiogenesis and promotes vessel normalization. Human cancer cell lines (Hs578T, MDA-MB-468, HCT116, SW620 or HT29) were fl uorescently labeled with DiI (in red) and injected into the PVS of 2 dpf Tg( fl i1:eGFP) zebra fi sh larvae
Fig. 5 Bevacizumab can modulate early and late metastatic steps. Schematic representation to distinguish between early and late metastatic steps (a).
Fig. 6 zPDX reveal different response pro fi les to bevacizumab. Human breast cancer or CRC surgical resected samples were injected into the PVS of 2 dpf Tg( fl i1:eGFP) zebra fi sh larvae

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