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The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer

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Academic year: 2021

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Figure

table 1: status of small adaptors that negatively regulate tK signaling in human cancers
figure 1: modular structure of small adaptors that negatively regulate tK signaling.  The size of adaptor proteins (number  of amino acids), presence of specific homology domains, sequences and myristoylation sites (Myr) are indicated
figure 2: A unifying model on how small adaptors control tK signaling.  Sustained receptor stimulation generally induces  expression of small adaptor proteins
figure 3: model of socs tumor suppressor function in human cancer.  A. In tumor cells with high SOCS expression, these  adaptor proteins inhibit tumor cell growth by controlling JAK/STAT-dependent cytokine signaling, and restrict integrin-dependent cell  i
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