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Alkyne Metathesis: Further Developments and Mechanistic Insights
Joaquin Geng Lopez, Maciej Zaranek, Piotr Pawluc, Régis M. Gauvin, André Mortreux
To cite this version:
Joaquin Geng Lopez, Maciej Zaranek, Piotr Pawluc, Régis M. Gauvin, André Mortreux. In Situ
Generation of Molybdenum-Based Catalyst for Alkyne Metathesis: Further Developments and Mech-
anistic Insights. Oil & Gas Science and Technology - Revue d’IFP Energies nouvelles, Institut Français
du Pétrole, 2016, 71 (2), pp.20. �10.2516/ogst/2015046�. �hal-01707485�
D o s s i e r
Special Issue in Tribute to Yves Chauvin
Numéro spécial en hommage à Yves ChauvinIn Situ Generation of Molybdenum-Based Catalyst for Alkyne Metathesis: Further Developments
and Mechanistic Insights
Joaquin Geng Lopez
1, Maciej Zaranek
2, Piotr Pawluc
1,2, Régis M. Gauvin
1and André Mortreux
1*
1
Univ. Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, UMR 8181 - UCCS - Unité de Catalyse et Chimie du Solide, 59000 Lille - France
2
Faculty of Chemistry, Adam Mickiewicz University in Poznan, Umultowska 89b, 61-614 Poznan - Poland e-mail: andre.mortreux@ensc-lille.fr
* Corresponding author
Abstract — Molybdenum-based catalysts are among the best candidates to achieve alkyne metathesis.
They can be either well-defined carbynes, previously synthesized before their use, but also prepared in situ upon using stable molybdenum carbonyl complexes, or high oxidation state molybdenum salts that need a previous alkylation, both type of precursors being “activated” by hydroxyl-containing compounds such as phenols and silanols. This paper is presenting studies made on these systems, directed towards the knowledge of the reaction paths leading to the active species, and in particular to define the essential role of hydroxyl-containing co-catalyst in the formation of the active species, still ill-defined. From an analysis of the byproducts formed during the reaction, as well as of the initial products, reaction paths to access catalytic carbyne species is suggested, where the ligand environment consists of phenoxy (or siloxy) groups, typically required and identified to lead to alkyne metathesis in the case of well-defined catalysts.
Résumé — Génération in situ de catalyseurs de métathèse des alcynes à base de molybdène : développements récents et approche mécanistique — Les catalyseurs à base de molybdène font partie des candidats les plus efficaces pour la métathèse des alcynes. Ceux-ci peuvent être soit des carbynes de molybdène préalablement synthétisés avant leur mise en œuvre, mais aussi préparés in situ via l’entremise de complexes à base de molybdène carbonyles, ou encore par alkylation de sels à haut degré d’oxydation, ces deux types de précurseurs nécessitant la présence de composés hydroxylés tels que des phénols ou silanols. Cette publication a pour objet de présenter des études visant à déterminer le mode de formation des espèces catalytiques impliquées dans ces deux systèmes, et en particulier du rôle du cocatalyseur hydroxylé, encore mal défini, dans la formation des espèces actives. De l’analyse des produits secondaires obtenus en cours de réaction, ainsi que des produits initiaux, on propose des voies de formation des espèces catalytiques de type carbyne, dont la particularité serait de disposer d’un environnement de ligands de type phénoxy (ou silyloxy), typiquement requis et identifiés pour favoriser le cycle catalytique relatif à la métathèse des alcynes sur des complexes carbynes bien définis.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABBREVIATIONS acac Acetylacetonato
Ar Aryl
Bu Butyl
Et Ethyl
GC Gas Chromatography OPPh
3Triphenylphosphine oxide
Ph Phenyl
P(OPh)
3Triphenylphosphite PPh
3Triphenylphosphine
Pr Propyl
Py Pyridine
TOF Turn Over Frequency
INTRODUCTION
In 1976 was held the fi rst metathesis symposium in Mainz, where our Nobel Laureate Yves Chauvin presented some work on tungsten-based catalysts generated from the well- de fi ned methoxyphenyl tungsten pentacarbonyl carbene complex and TiCl
4for cyclopentene ring-opening polymer- ization [1]. During the same event, one of us presented some results related to the use of molybdenum hexacarbonyl as precursor for alkyne metathesis when associated with phenol as co-catalyst [2, 3]. Since more than four decades, tremen- dous efforts have been devoted to the search of new catalysts for metathesis reactions in general, in particular via the syn- thesis and use of well-defined, active metathesis catalysts, essentially based on ruthenium, tungsten and molybdenum.
In that context, a strong interest has been devoted within the last decade to the synthesis of molecular initiators for alkyne metathesis, as revealed by recent publications in the field [4-7]. However, the use of in situ catalysts still remains of interest both from academic and industrial point of views, as they are generally prepared using procedures that are less sensitive to oxygen and water, whereas the synthesis and uses of well-defined and active carbenes or carbynes would require their prior synthesis and working under more specific experimental conditions.
Since our former, seminal work on molybdenum carbonyl as catalyst precursor, our interest on the alkyne metathesis reaction has been focused in the early 80s on the use of higher oxidation state molybdenum complexes, which when associated with an alkylating/reducing agent, and again a phenol as co-catalyst, have been shown to be two orders of magnitude more reactive than the former ones. This has been exemplified in a short series of papers where MoO
2(acac)
2/AlEt
3/PhOH combinations were shown to be active at room temperature [8] and could be applied to
functionalized alkynes [9], whereas some mechanistic insights related to the catalytic reaction have been developed [10].
The aim of this paper will be to describe further in situ cat- alytic systems based on different high oxidation state molyb- denum complexes and salts, and to show the versatility of this methodology for obtaining efficient alkyne metathesis catalysts. A careful analysis of the reaction by-products will be performed on these catalysts, as well as on Mo(CO)
6/ArOH systems, aiming at the knowledge of the reaction paths that could lead to the active metathesis species and their ligands environment. Examination of the structure of these by-products will allow suggesting the production of aryloxy molybdenum complexes, closely similar to the well- known carbyne complexes active in this metathesis reaction [11, 12].
1 EXPERIMENTAL SECTION
1.1 Molybdenum Complexes Precursors
MoO
2(acac)
2was purchased by Fluka. The complexes MoCl
2(NO)
2L
2(L = Py, NEt
3, PPh
3, P(OPh)
3, OPPh
3) were prepared according to the literature, via the synthesis of polymeric [MoCl
2(NO)
2]
n, obtained by reaction between Mo(CO)
6and NOCl [13].
1.2 Catalytic Reactions
All reactions were carried out under argon in a reactor which typically consists of a round bottom glass flask of ca. 40 mL capacity equipped with a septum for sampling and sealed on a ca. 40 cm height, 2 cm diameter tube to allow condensation of the solvent during reactions conducted at high temperature
1.
In a typical experiment, the molybdenum complex (0.1 mmol) was introduced in a Schlenk tube, solubilized in 9.4 mL toluene and 0.6 mL of a molar solution of AlEt
3in toluene. The alkylation process was done at room temper- ature during 5 min. 1 mL of this solution was then introduced into the reactor containing a 9 mL solution of 1 mmol alkyne (4-nonyne or 4-decyne) in toluene, 1 mmol phenol or silanol cocatalyst as well as 0.5 mL undecane as internal standard, previously heated at the required reaction temperature.
Aliquots were taken regularly using a syringe via the sep- tum, and immediately poured into a soda solution to stop the reaction and avoid the presence of phenol in the organic phase, which was then analyzed by GC on a Shimadzu
1
This reactor model allows avoiding the presence of any trace of silicon
grease, whose residual Si-OH groups are prone to act as co-catalysts in this
reaction.
GC2014 apparatus equiped with a FID detector and using N
2as carrier gas. A Supelco Equity-5 column (95% meth- ylpolysiloxane + 5% phenylsiloxane, 30 m 9 0.32 mm 9 0.25 lm) was used starting at 100°C for 5 min, followed by a temperature program of 20°C/min for 5 min, and stabi- lized at 200°C. Conversions and selectivities were calculated via the internal standard method.
1.3 By-Products Production and Analysis 1.3.1 MoO
2(acac)
2/AlEt
3/PhOH
In the catalytic reactor described above were introduced 2.5 mmol phenol, 5 mL toluene, 1 mmol 4-octyne and 0.1 mL undecane. After complete solubilization of phenol, the catalyst was prepared as before, and all the alkylated molybdenum solution (corresponding to 0.1 mmol Mo) was introduced at room temperature; aliquots were taken from time to time to follow the evolution of the by-products formation and analyzed by GC-MS.
1.3.2 Mo(CO)
6/ArOH
0.05 mmol of Mo(CO)
6, 1 mL of toluene, 0.5 mmol of 4-octyne, 0.5 mmol of phenol or chlorophenol and 100 lL of undecane were introduced in the reactor. The mixture was stirred and heated at 110°C. Samples were taken and analyzed using the GC-MS apparatus described below.
1.3.3 GC/MS Analysis
GC-MS analyses were performed on a Bruker SCION- 436GC – Bruker SCION SQ MS equipped with a 0.25 mm, 30 m-long Agilent DB-5 capillary column. The carrier gas was helium using a column flow of 1.0 mL/min and a temperature program of 10°C/min starting at 60°C (hold 3 min) and ending at 250°C (hold 13 min);
EI: 70 eV.
2 RESULTS AND DISCUSSION
Within the frame of this paper, we will first present and com- pare catalytic results that have been observed on catalytic systems based on high oxidation state dioxo and dinitrosyl molybdenum/AlEt
3/ZOH catalysts for alkyne metathesis, with regard to the use of various and selected ligand environ- ment. A second part will be devoted to analysis of the by- products of these reactions, as well as those observed on molybdenum hexacarbonyl/ArOH catalysts. Mechanistic considerations will be made, leading to the assumption that the co-catalyst should give rise to the formation of high oxidation state catalysts in both cases.
2.1 Dinitrosyl Molybdenum Based Catalysts
As described in a previous paper [8], the MoCl
2(NO)
2(Py)
2/ AlEt
3/PhOH combination is an active and selective catalyst for 4-nonyne metathesis at toluene re fl ux, the reaction being at equilibrium within minutes at a CC/Mo ratio of 100 (Eq. 1):
C
3H
7C
4H
9C
3H
7C
3H
7C
4H
9C
4H
9+ 2
(1) The association of dinitrosyl molybdenum complexes/
chloroalkylaluminum reagents to produce alkene metathesis catalysts has been known for a long time, as the first paper in the field has appeared very early in the corresponding liter- ature, when the reaction was so called “disproportionation”
[14, 15]. Of interest in the corresponding papers is that a com- parison was made using molybdenum versus tungsten dinitro- syl complexes. This led to the conclusion that molybdenum- based catalysts are more reactive, and that the use of different ancillary, two-electron donor ligands also led to various activ- ities. In line with these results, we performed metathesis reac- tions on 4-nonyne using the same procedure as described above, with different phosphorus and nitrogen ligands, using phenol as standard co-catalyst. The reactions were all run at 110°C for comparison. All reactions led to the equilibrium within minutes, with a complete selectivity into 4-octyne and 5-decyne. The results are reported in Table 1.
The use of chlorobenzene as solvent only affects the reac- tivity to a small extent, and a comparison of the results obtained on the different pre-catalysts leads to the conclu- sion that the less coordinating ligands triethylamine and tri- phenylphosphine oxide gave the best results. It must be emphasized that using polymeric [Mo
2Cl
2(NO)
2]
ngave also good results (entry 6), but due to the poor solubility of this precursor in toluene, the activation procedure needed a much longer reaction time with the alkylating reagent AlEt
3, as exemplified by the evolution of the activity versus alkylation time at 60°C (Tab. 2).
TABLE 1
Activity of the MoCl
2(NO)
2L
2/AlEt
3/PhOH for 4-nonyne metathesis
Entry 1 2 3 4 5 6
L Pyridine NEt
3PPh
3P(OPh)
3OPPh
3None TOF (h
1)
a3300 4400 3950 3700
c4750 3600
dTOF (h
1)
b2150 3000 3650 2400
c3800 3600
dConditions:
T= 110
°C; [C C]/[Mo] = 100; [AlEt
3]/[Mo] = 6;
PhOH/Mo = 100.
a
Toluene as solvent.
b
Chlorobenzene as solvent.
c
Selectivity into metathesis products decreases to 50%.
d
The use of a longer activation time was necessary (Tab. 2 below).
An interesting feature to be noticed is the fact that with all catalytic systems, a further loading of alkyne was immedi- ately metathesized to equilibrium, thus demonstrating the robustness of such systems.
2.2 Catalytic Results on the MoO
2(acac)
2/AlEt
3/ArOH or Si-OH Catalysts
The MoO
2(acac)
2/AlEt
3/PhOH combination developed ear- lier [8, 10] has been the subject of some studies in this reac- tion. This section will first give data related to the effect of alkyne/Mo ratio, and in a second part will study the effect of the nature of the hydroxyl-containing co-catalyst on the reaction rate.
2.2.1 Effect of the Alkyne Concentration on the Reaction Rate The evolution of the reaction rate versus the co-catalyst con- centration has already been described, showing that the reac- tion was following a kinetic law in which a first order had to be applied to the phenol co-catalyst [8]. Of interest would also be to know the effect of the alkyne/Mo ratio on the activity, using constant concentration of molybdenum (10
3M) and phenol (10
1M). These reactions were con- ducted at 110°C (Tab. 3).
The evolution of the turnover frequency confirms that the reaction rate law is first order in alkyne, what was expected if considering the previous results already found at 60°C [10].
It has to be emphasized that this result corresponds to a 15-fold increase of the turnover rate upon increasing the temperature from 60 to 110°C. Such high values (40 s
1) are more relevant to a “ very high ” activity rating on single site ethylene polymerization catalysts [16], and to the best of our knowledge, have no precedent in the field of alkyne metathesis.
Applying this catalytic system to functionalized alkynes have proved to be successful in some cases: using a substrate/
PhOH/Mo ratio of 1000/100/1, the non-conjugated enyne 1-nonene-4-yne was successfully metathesized on the triple bond, the terminal double bond remaining intact, with a turnover rate of 1 680 h
1. The chloro-substituted 7-chloro- 3-heptyne had a reactivity similar to that of the alkyl disubsti- tuted alkynes, affording turnover rates of 60 000 h
1[9].
As compared with the MoCl
2(NO)
2L
2catalyst reported above, a comparison can be made using the results observed at 110 ° C with a 100/100/1 (C C/PhOH/Mo) ratio (Tab. 3), the bis (acetylacetonato) dioxomolybdenum compound being ca 1.5 times more active than the best bis-(triphenyl- phosphine oxide) dichlorodinitrosylmolybdenum complex (Tab. 1, entry 5).
2.2.2 Effect of Different Co-Catalysts on the Reaction Rate Since its discovery, the original Mo(CO)
6/resorcinol catalyst have been the subject of variations on the nature of the co-catalyst. Phenol itself and chlorophenol, as well as sila- nols and fluoro alcohols were rapidly recognized as suitable to activate the reaction, and revealed that such hydroxyl- containing compounds were essential for the reaction to proceed [17]. Following this paper, several reports aimed at the search for the best co-catalyst to be used for these in situ systems have appeared in the literature, for classical metathe- sis reactions conducted on disubstituted alkynes [18], and also for comparisons between the MoO
2(acac)
2/AlEt
3/ArOH and the Mo(CO)
6/phenol catalytic systems applied to polymeriza- tion reaction of aromatic diynes [19]. In this paper were also reported data where different fluoro-substituted phenols were used, confirming that the use of different co-catalysts results in different reaction rates.
Our objective has then been to look for the effect of variation of the phenol/silanol (ZOH) co-catalyst on the reaction rate during metathesis of 4-decyne on alkylated MoO
2(acac)
2/AlEt
3/ZOH system. For this study, we deliber- ately chose to conduct the reactions at 20°C, so as to obtain more accurate results in terms of comparison. These results using 4-decyne as substrate are reported in Table 4, and Figure 1 presents the kinetic profiles of the reactions.
Upon analysis of these results, it appears that although the best initial activity is achieved with o-fluorophenol, 3- and 4-chlorophenol gave rise to higher global turnovers, although none of the reactions is going to equilibrium. In some cases (entries 3 and 10), such a comparison is useless at this temperature, as the co-catalysts are only sparingly sol- uble or insoluble in toluene: any conclusion about their potential behavior as activator at higher temperature must therefore be excluded. It must be noticed however that the
TABLE 3
Effect of alkyne/Mo ratio on reaction rate on the MoO
2(acac)
2/AlEt
3/PhOH catalyst at 110
°C
4-nonyne/
Mo 10 100 200 500 1000 1500 2000
TOF
(h
1) 650 7000 12700 32000 62500 100250 144000 Conditions: solvent: toluene; [Mo] = 10
3M; [AlEt
3]/[Mo] = 6; [PhOH] = 10
1M;
T= 110
°C.
TABLE 2
Evolution of the 4-nonyne metathesis rate
versusthe activation time of [Mo
2Cl
2(NO)
2]
nActivation time
(min) 5 10 20 30 40 50 60
TOF (h
1) 57 78 200 360 385 465 516
Conditions: Same as in
Table 1, toluene as solvent.T= 60
°C.
more acidic halogeno-substituted phenols are much better than phenol, as found earlier on Mo(CO)
6/ArOH-based catalysts [17, 18], although no direct relationship between the activity and the pKa value of the co-catalysts could be found. This is similar to what was observed in several cases
where a systematic study of the reactivity of in situ generated catalysts was conducted. These include the thermally acti- vated Mo(CO)
6/ArOH catalysts during ring-closing metath- esis of a functionalized diyne [18], as well the screening of alcohols and phenols for the in situ synthesis of aryloxy- molybdenum carbyne complex from trisamido molybdenum alkylidynes, where again the authors have found that no correlation could be found between the phenol/alcohol pKa values and the performance in ring-opening polymeri- zation of ring-strained dibenzo[a,e]-8-annulene [20].
It appears from these results that the high oxidation state molybdenum/AlEt
3/ArOH-based catalytic systems are by far much more reactive than thermally activated Mo(CO)
6/PhOH, for which, using phenol as activator, a turn- over frequency of 120 h
1was found (versus 7000 h
1) [8].
2.3 Mechanistic Insights
2.3.1 Previous Mechanistic Considerations
The reaction mechanism of these in situ catalytic systems based on molybdenum/ArOH combinations has been the sub- ject of part of a review [21] where considerations using previ- ous results on the MoO
2(acac)
2AlEt
3/PhOH combination in our group led to the conclusion that transient metallacyclobut- enes might be key intermediates of the catalytic cycle [11, 12].
This hypothesis was supported by several observations which are:
– the detection of alkenes at the beginning of the reaction, arising from a reaction between an ethylidene metallacar- bene initially formed during the alkylation step of the molybdenum salt by triethylaluminum;
– the fact that a first order reaction rate in phenol was estab- lished [8];
– the occurrence of an interaction via H-bonding between the proton of the hydroxyl group of the phenolic cocata- lyst and the alkyne triple bond [17, 22, 23].
On the other hand, a mechanism involving the occurrence of metallacarbynes as active species and metallacylobutadi- ene intermediates in this metathesis has been first suggested by Katz and McGinnis [24], and established by McCullough and Schrock via the synthesis of well-defined tris-aryloxy molybdenum complexes [25].
Considering the fact that the reaction of Mo(acac)
3with triethylaluminum reduces the molybdenum salt to Mo(0), as attested by the synthesis and successful use of Chatt ’ s complex Mo(N
2)
2(dppe), successfully used as precatalyst in the presence of phenol [9], we anticipated that in some way, the hydroxyl containing co-catalyst should react on molybdenum to provide higher oxidation state molybdenum species, more prone to provide active metathesis catalysts.
The question was then to know how such Mo species can be produced: the following section, dealing with a deeper
TABLE 4
Initial activity and conversion of the MoO
2(acac)
2/AlEt
3/ZOH for 4-decyne metathesis
Entry Co-catalyst pKa TOF (h
1) Conversion (%)
1 2,3,4,5,6-F
5-ArOH 5.35 0 -
2 3,4-Cl
2-ArOH 8.5 53 26
3 Resorcinol
a9.1 0 -
4 2-F-ArOH 8.7 76 26
5 3-Cl-ArOH 8.9 59 33
6 4-Cl-ArOH 9.3 56 30.5
7 ArOH 9.9 22 19
8 2,6-(CH
3)
2-ArOH 10.6 0 -
9 (C
6H
5)
3SiOH ~ 12
b12.5 5.0
10 (C
6H
5)
2Si(OH)
2a~ 12
b0 -
11 (CF
3)(CH
3)
2COH 11.8 0 -
12 (CF
3)CH
2OH 12.5 0 -
Conditions:
T= 20
°C, solvent: toluene; [C C]/[phenol or silanol] = 1;
[C C]/[Mo] = 100; [AlEt
3]/[Mo] = 6.
a
Insoluble in toluene.
b
Estimated value of the pKa.
35 30 25 20
Conversion (%)
15 10 5
00 1 2 3 4 5
3,4-Dichlorophenol (pKa 8.55) 3-Chlorophenol (pKa 8.9) 4-Chlorophenol (pKa 9.3) Phenol (pKa 9.9) 2-Fluorophenol (pKa 8.7)
Time (h)
Figure 1
Reaction pro
files during 4-decyne metathesis using different
co-catalysts in the MoO
2(acac)
2/AlEt
3/Z-OH systems. See
Table 4for conditions.
examination of the by-products formed during the reaction will try to give some answers to this key problem.
2.3.2 Analysis of the By-Products Formed during Metathesis As stated before, we had analyzed the initial by-products at the early stage of the alkyne metathesis using MoO
2(acac)
2/AlEt
3/ArOH as catalyst [11, 12]. However, analyzing more carefully the GC chromatograms conducted at higher temperature revealed that small amounts of higher molecular weight products – in sub-stoichiometric quantities versus the catalyst – were also formed.
We were therefore interested to analyze these reaction by- products, as determination of their nature could provide some elements related to the formation of the active species.
To avoid the presence of too many products arising from the occurrence of the metathesis process, the reactions were conducted using a symmetrical alkyne, 4-octyne, and GC/MS analysis was then applied to assign their structure.
Compounds 1 , 2 , 3 and 4 were formed (Fig. 2).
Analyzing their relative amounts indicates that substituted butadienic compounds 1 and 3 are produced in higher amounts than the cyclotrimer 2 , whereas this aromatic trimer becomes the major compound in the absence of phenol.
This observation prompted us to use a similar procedure aimed at the search for similar products when using our for- mer Mo(CO)
6/ArOH catalyst. Compounds 1, 2 and 3 were also indeed produced, together with compounds 5 and 6 .
In Figure 3 are reproduced in the upper part of the GC spectrum of a reaction conducted for 4 h at toluene reflux, using 10 eq 4-octyne versus Mo(CO)
6, with and without chlorophenol.
Remarkably, the comparison of the GC chromatograms reveals several interesting features:
– one may find once more in the GC analysis 1 and 2 as the major products;
– the relative amount of aromatic trimer versus the butadie- nic compounds slightly decreases when using the pheno- lic reagent;
– worth to mention is also the fact that using Mo(CO)
6without activator, after longer time (8 h), the tetrapropyl- cyclopentadienone 5 and the butylidene tetrapropylcyclo- pentadiene 6 were produced in larger amounts than when using the phenolic compound.
2.3.3 Discussion
The co-production of tetra-substituted butadienic com- pounds 1 and aromatic cyclotrimers 3 from disubstituted alkynes is scarcely described in the literature. One of these involves the use of MoCl(CO)
2(g
3-C
3H
5)(NCMe)
2, which converts 6 eq of PhC CPh when heated in methanol at reflux for 24 h into a mixture of hexaphenylbenzene (58%) and (E,E)-1,2,3,4-tetraphenylbutadiene (34%) [26]. More relevant to our concern is an attempt to establish the catalytic mechanism of the alkyne metathesis on Mo(CO)
6/ArOH cat- alyst by Nishida et al. [27], who also reported the synthesis of butadienic compounds as minor products during the cross metathesis reaction between symmetrical alkyne and a dial- kyne, affording mainly the aromatic [2+2+2] co-cyclization product. This reaction was done using a huge amount of
“catalyst” (35 mol%), and the author suggested that the production of both compounds should arise from transient metallacyclopentadienes intermediates, which were also suggested to be key intermediates for metathesis, via a hypo- thetic scrambling of the alkyl groups on the metallacycle via cyclobutadienic complexes and reverse reaction [28] (Fig. 4).
The expansion of the metallacycle via insertion of a third alkyne would produce the aromatic compound after reduc- tive elimination. In this paper however, there has been no discussion about the role of the co-catalyst in the catalytic process, neither on the molybdenum ligand environment.
From that point of view, some proposals were made by several authors, where the phenolic co-catalyst would react on molybdenum species, leading to aryloxy-molybdenum carbynes of (ArO)
3MoCR type [26, 29, 30]. However, in no case was reported the identi fi cation of such species, and how they could be formed from the reaction mixture consist- ing of Mo(CO)
6and phenols.
The observation of the formation of butadienic com- pounds 1 in the medium is a key feature on which we then focused our attention, and isotopic labeling experiments have been performed using deuterated phenol to probe whether a protonolysis (deuterolysis) of the metallacyclo- pentadienic intermediates could occur. This procedure has already been used by Ibragimov et al. to provide evidence for the formation of aluminometallacycles in reactions involving alkynes and diethylaluminum chloride [31].
Indeed, this reaction leads to the production of partly deu- terated 1,2,3,4–tetrapropylbutadiene (Fig. 5)
Our assumption and hypothesis is therefore that com- pounds 1 arise from a reaction between the tetra-alkyl
R R
R R R
R R R
R R
R R R
R R
R R
R R
Me
1a, 1b, 1c.
(3 isomers)
2 3 4 5 6
R
R R R
O
R
R R R
R
Figure 2
Reaction by-products observed during metathesis of 4-octyne
on MoO
2(acac)
2/AlEt
3/PhOH and Mo(CO)
6/ArOH catalytic
combinations (R = Pr).
cyclopentadienyl molybdenum intermediates and excess phenol, which in turn should also produce aryloxy-molybde- num species. Worth to be reminded at this point is the fact that the kinetic studies have shown a first order dependence of the reaction rate in phenol concentration, which may here be justified, if considering that this protonolysis reaction would be the rate determining step. Among others such as triphenylsiloxy molybdenum carbynes recently studied in depth by Heppekausen et al. [32], these aryloxy species are known to be ideal ligands to provide active molybdenum carbyne complexes for alkyne metathesis, as compared with tungsten-based catalysts [33]. Figure 6 is representative of the preceding hypothesis, where the production of a (PhO)
2Mo transient intermediate is therefore suggested, fol- lowing the preliminary molybdenacyclopentadiene complex formation.
This hypothesis does not preclude the possibility of formation the aromatic trimers, which can be produced by
a further insertion of alkyne into the cyclometallated species as a competitive reaction. Of interest is also the fact that use of phenol avoids the production of the cyclopentadienone by-product: an insertion reaction of remaining CO moieties in the metallacyclopentadienyl molybdenum species would indeed lead to this ketone after reductive elimination, a pro- cess that is in competition with the protonolysis reaction.
The production of tetraphenyl-substituted cyclopentadie- none molybdenum complexes was reported very early by Hübel and Merenyi [34] during a reaction involving diphen- ylacetylene and Mo(CO)
6at high temperature, where other dinuclear molybdenum cyclobutadienic complexes were synthesized [34] and well-characterized by Potenza et al.
[35]. Notably also in the synthesis of these complexes is the fact that pentaphenylcyclopentadiene and (Ph
5C
5)
2Mo were also produced, which corresponds in our case to com- pound 3 . Furthermore, with regard to this hypothesis, one may also consider our previous observations made on the
3-Chlorophenol (4h) (8h) Without activator (4h)
4.0
C3H7C3H7
C3H7
C3H7 Exact mass: 330.3
Exact mass: 288.3 Exact mass: 276.3
12.620 min +12.790 min +13.410 min 13.750 min 14.594 min 15.687 min +15.947 min +16.139 min
+13.036 min 16.072 min 16.439 min 16.800 min 17.941 min + 18.082 min 18.235 min +18.614 min 18.911 min 19.094 min
2
C3H7
C3H7
3 6 1
C3H7
C3H7
C3H7
C3H7
C3H7
Exact mass: 248.2
5
C3H7
C3H7 C3H7
C3H7
C3H7 C3H7
C3H7
C3H7
O
C3H7
Exact mass: 236.2 Exact mass: 222.2
C3H7
C3H7
C3H7
C3H7
C3H7 C3H7
O
C3H7
C3H7
3.5 3.0 2.5 2.0 1.5 1.0 0.5 5
2 1
60 50 40 30 20 10 0
13 14 15 16 17 18 19 20
minutes
Figure 3
GC chromatogram of the higher molecular weight products obtained upon heating Mo(CO)
6and 4-octyne with and without phenol at toluene
re
flux for 4 and 8 h.
reactivity of the system upon using [alkyne+Mo(CO)
6] mixtures previously heated at toluene re fl ux before phenol addition, which after rapid cooling gave catalytic activity at room temperature, whereas premixing and heating Mo(CO)
6and phenol followed by alkyne addition led to a totally inactive system [2, 3, 17]. The reaction path(s)
leading to the aryloxy Mo species described in Figure 6 are in total agreement with these experimental facts.
As for the presence of compound 4 , a mechanistic pro- posal may be suggested, which would involve an intramo- lecular insertion reaction of these carbenic moieties into a molybdenacyclopentadiene (Fig. 7).
2010-07-31 phenol-d 6-4h. SMS K Counts
0%
150 175 200
Exact mass: 224.2 C3H7
C3H7
C3H7
C3H7
D D
225
M
+(222) M
+-d
2(224) M
+-d
1(223)
12.5 15.0 17.5 20.0 22.5 25.0 minutes27.5
m/z 10%
20%
30%
40% Spectrum 1A 14.966 min. Scan: 1044 45:650 ion: 9613 us RIO: 21428 (BO)
BP 81.00 (908-100%) 2010-07-31 phenol.d6-4h. sms
24 22
51 133.90 135.00
145.30 153.10 152.00 139.00
138.00
229 413
165.00
180.20
179.00
182.00
194.10
195.00
207.00
223.00
221.10 222.10
173
39 211
37 192.00
95
43 127
68 379
249
167.00 138
49 139
83
10 20 30 40 50 60 70 80
Figure 5
Mass spectrum of 1,2,3,4-tetrapropylbutadiene obtained upon heating C
6D
5OD and Mo(CO)
6with 4-octyne.
R2 R1
R2 R1 [M]
R1 R1
R2 R2 [M]
[M] R2 R2
R1 R1
[M] R2 R1
R1 R2 R1
R2 R1
R2 [M]
R1
R2 R1
R2 [M]
R2 R1
R2 [M]
R1 R1
R1 R2 R2
R1
R1 R1
R2
R2 R2
+ Isomers 2
Figure 4
Metallacyclopentadiene-type mechanism for alkyne metathesis on Mo(CO)
6/ArOH-based catalysts [28].
The hypothesis of such an intramolecular reaction is supported by earlier work made on a (cyclopentadienyl) metallacylopentadienyl cobalt complex, which upon a diazacarbene addition provides the corresponding cyclopenta- diene-substituted compound (Fig. 8) [36].
Compound 6 is only present as by product when using Mo(CO)
6as pre-catalyst
,where due to the presence of car- bon monoxide, the cyclopentadienone 5 is produced. In Figure 9 is described the way by which this ethylidene compound may be formed, via a Wittig-like reaction with a molybdenacarbene species.
If one assumes that metallacarbyne species are present in the reaction medium, this would indeed explain the presence of metallacarbenes arising from an addition reac- tion of phenol used in large excess, a process recognized earlier as an entry to metallacarbene species [37]. Note that this reaction path also produces an oxidized Mo=O
species, which may be a termination process for metathesis.
The question then would arise to know how metallacarbynes can be involved as active species and how they are formed.
As far as all attempts to detect or isolate such intermediates have failed in our hands, probably due to the extreme reactivity of these intermediates, what is following will only aim at suggesting some hypotheses on the formation of metallacarbyne species. One possibility would be to con- sider a further oxidative addition of phenol on the highly reactive aryloxy (PhO)
2Mo to produce the unstable Mo(IV) (PhO)
3MoH intermediate or Mo(OPh)
4. Both would dimerize and produce the (PhO)
3MoMo(OPh)
3dimer, with concomitant release of dihydrogen or reduction, respectively. A metathesis reaction with the alkyne would give rise to the (PhO)
3MoC-R initiator of the metathesis process. In support of this assumption, such a metathesis reaction between MoMo dimers and disubstituted alkynes has indeed been reported (Fig. 10) [38], and already
[Mo]
R R1
R
R
R R
R R
R
H [Mo]
H R1
R R
2 [Mo]
R
R R R
[Mo] +
H R1 H R1
R = Pr, R
1= Me
4Figure 7
Proposed mechanism of formation of methyl tetrapropyl-cyclopentadiene
4.Co PPh
3N
2CHCOOEt Co H COOEt
Figure 8
Synthesis of cyclopentadiene compound from the triphenyl- phosphine (cyclopentadienyl) metallacyclopentadienyl cobalt complex.
R R
R R [Mo]
H
R
+
OR R R
R
R H
[Mo] O
+
5 6
Figure 9
Plausible pathway for the formation of compound
6as by-product.
[Mo] + R R [Mo]
R
R R
ArOH R
H R
R R
H R
[Mo] OAr OAr
2 [Mo]
R
R R
R R
R
R R
R R
R R R
R CO
R R R R
O [Mo] R
R R R
O
+ 1
2
5
Figure 6
Suggested mechanism for the synthesis of molybdenum aryloxy species from
in situ-generated [Mo]/PhOH/alkyne catalytic system.suggested earlier as a key reaction leading to the active spe- cies on Mo(CO)
6/ArOH systems [29].
On the other hand, if the activities obtained on molybde- num carbonyl-based catalysts are of the same order of those observed on tris(aryloxy)molybdenum carbynes generated in situ from tris amido precursors, the activities obtained on the catalytic systems based on the higher oxidation state dioxo and dinitrosyl MoO
2(acac)
2and MoCl
2(NO)
2L
2-/
AlR
3/ArOH combinations are almost two orders of magnitude higher, so that the question would be to know whether the active molybdenum species are the same in both systems and/or if the initiation process generates a similar quantity of active species. Another point worth to be considered is the fact that the alkylation procedure could give rise to another route for the metallacarbyne(s) generation.
As the role of phenol is now assigned differently from the one we proposed earlier, it seems necessary to us to revisit the experimental data that we published more than two decades ago, where a thorough GC analysis of the byprod- ucts in the alkenes and alkyne range was performed on the MoO
2(acac)
2/AlEt
3/PhOH combination [10]. Starting from 4-nonyne as the substrate and conducting the catalytic reaction between 0 and 20°C allowed detection of 2-hexenes, 3-heptenes and concomitantly 2-heptyne and 2-hexyne as primary products before the appearance of the expected metathesis products 4-octyne and 5-decyne. That means that the initiation process is different from the one using the Mo(CO)
6/PhOH catalysts: the presence of these by products is consistent with the formation of not only eth- ylidene Mo=CHMe species via H abstraction on the [Mo]CH
2CH
3moiety formed by transalkylation, but also ethylidyne [Mo]C-Me, responsible for the initial produc- tion of 2-hexyne and 2-heptyne via reaction with 4-nonyne.
As a matter of facts, a fine tuning of the experimental con- ditions was necessary to achieve good results, i.e. the rigor- ous respect of the protocol related to the order of addition of the catalyst components, substrate and phenol, otherwise the reaction course deviates. These conditions are as follows:
– premixing of the molybdenum salt and triethylaluminum (1/6 ratio) at 0°C for 30 min;
– premixing of the alkyne and phenol at room temperature for 10 min;
– injection of the alkylated solution in the alkyne–phenol solution at the desired reaction temperature.
Any other protocol would give either no reaction, or poly- merization if phenol is added before the introduction of alkyne.
Considering the literature devoted to the synthesis of alkylidyne molybdenum complexes, it appears that this sys- tem is closely related to the synthesis of trisalkoxymolybde- num (VI) alkylidyne complexes [39], where in a first step, using a Grignard reagent, molybdenum salts are alkylated and give stable trisalkylmolybdenum carbynes, via two suc- cessive a-H abstraction reactions. Although the alkylating reagent is here different, a possible way to phenoxymolyde- num carbyne active species may therefore come from a first alkylation/alkynylation followed by protonolysis of at least one molybdenum alkyl bonds by phenol in large excess, leading to an alkyl phenoxy metallacarbyne moiety. It appears therefore that most probably, our protocol is a one pot way by which the expected carbyne species are formed.
Introducing phenol before the alkyne would rather produce metallacarbenes via reaction with the phenolic reagent with the carbyne moiety. Metallacarbenes are indeed well-known to straightforwardly polymerize alkynes (Fig. 11). Worth to be mentioned here is the fact that tungsten alkylidene have been shown to rapidly interconvert with alkylidyne com- plexes in the presence of acids, a reaction which may also be here catalyzed by the presence of phenol [37].
Beyond these considerations which show how the alkyl- ation process on high oxidation Mo salts results in the pro- duction of carbyne species differently from those arising from Mo(CO)
6alone, another plausible and interesting alter- native could be however envisaged considering data already published in the literature on such molybdenum salts/
alkylaluminum devoted to their use as alkene metathesis cat- alysts, both on dioxo and dinitrosyl complexes. The reaction of dinitrosylmolybdenum complexes with chloroaluminum alkyls has been indeed the subject of several reports, as these were active catalysts in alkene metathesis, as already men- tioned [14, 15]. Of interest is the fact that the dinitrosyl ligands were found to be still present in these reactions, in particular when using alcohols as modifiers [40, 41]. This means that in our system, the ancillary ligands could also be a combination of a dinitrosyl and aryloxy moieties, giving
2 [M]
ArO ArO
2 ArOH
[M]
ArO ArO
OAr H
2 [M] [M]
ArO ArO ArO
OAr OAr -H
2OAr
Metathesis