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An epitranscriptomic switch at the 5´-UTR controls genome selection during HIV-1 genomic RNA packaging

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Academic year: 2021

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Figure 1: The presence of m 6 A alters the in vitro folding and dimerization of the HIV-1 full-length RNA 5´-UTR
Figure 2: The presence of m 6 A within the full-length RNA favors Gag synthesis but interferes with packaging
Figure 5: Inhibition of FTO demethylase activity impacts full-length RNA metabolism and blocks packaging
Figure 6 Working model for the epitranscriptomic regulation of HIV-1 full-length RNA packaging

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