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Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells

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Academic year: 2021

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Table S1). Interestingly, we found that the level of the miRNAs present in the exosomes is not simply the  re-flection of their abundance inside the cells (Figure 3A).
Figure S3A). The apoptotic effect is not mediated by cytokines or other soluble factors carried over during the isolation procedure since incubation of recipient MIN6B1 cells with the supernatants recovered after ultracentrifugation of the exosome preparat
Figure 3 Profiling of miRNAs released in exosomes by MIN6B1 cells in the presence or absence cytokines
Figure 4 Exosomes from cytokine-treated cells induce apoptosis of recipient naïve beta-cells
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