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A comparison of bootstrap approaches for estimating uncertainty of parameters in linear mixed-effects models.

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Academic year: 2021

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Table 1 – Bootstrap methods that can be applied in mixed-effects models Variability related to subject
Table 3 – Coverage rate of the 95% CI of parameters by REML obtained by the asymptotic method and the bootstrap methods in the 3 studied designs
Figure 1 – The evolution of UPDRS score over time in the real dataset used for the simulations, including 109 patients who remained in the placebo group over the first two years
Figure 2 – Examples of simulated data for each design
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