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32P-Postlabeling of a DNA adduct derived from 4,4′-methylenedianiline, in the olfactory epithelium of rats exposed by inhalation to 4,4′-methylenediphenyl diisocyanate

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Academic year: 2021

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Fig. 1. The two possible pathways for the formation of DNA adducts by MDI: (left) the enzyme-independent reaction of nucleophiles with the electrophilic isocyanate group of MDI forming isocyanate adducts; (right) the enzyme-dependent reaction after hydroly
Fig. 4. (A) 32 P-postlabeling maps of DNA isolated from the olfactory epithelium of a control rat of the MDI aerosol study; (B) from the olfactory epithelium of a rat exposed to 2.1 mg/m 3 MDI aerosol for 1 year, (C) from the liver of a MDA-treated rat;

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