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Recurrent 11q24.3 gain contributes to the pathogenesis of diffuse large B cell lymphoma by deregulating ETS1 and FLI1

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Thesis

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Recurrent 11q24.3 gain contributes to the pathogenesis of diffuse large B cell lymphoma by deregulating ETS1 and FLI1

TESTONI, Monica

Abstract

DLBCL is the most frequent and aggressive form of non-Hodgkin's lymphoma. The still high percentage of mortality is in part due to the heterogeneity of DLBCL at genetic level. Among genetic alterations, a recurrent gain at 11q24.3 was detected in 26% of DLBCL. It was associated with higher expression of ETS1 and FLI1 transcription factors. Silencing of both genes led to cell death and a block in proliferation in a DLBCL cell line bearing the specific 11q gain but only FLI1 silencing gave a similar phenotype in cell lines without the gain. At molecular level, ETS1 directly and negatively regulates BLIMP1 expression. Importantly, ETS1 or FLI1 silencing leads to changes in the expression of B cell important genes. This project reveals ETS1 and FLI1 as interesting drug targets to be further analyzed. In addition, the status of MYC gene was analyzed in this cohort of DLBCL patients treated with R-CHOP.

TESTONI, Monica. Recurrent 11q24.3 gain contributes to the pathogenesis of diffuse large B cell lymphoma by deregulating ETS1 and FLI1 . Thèse de doctorat : Univ. Genève, 2014, no. Sc. 4669

URN : urn:nbn:ch:unige-392076

DOI : 10.13097/archive-ouverte/unige:39207

Available at:

http://archive-ouverte.unige.ch/unige:39207

Disclaimer: layout of this document may differ from the published version.

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Appendix tables

These data are available online as Supplementary Tables of the paper Bonetti P*, Testoni M* et al. Blood 2013;122 (13): 2233-2241.

Table A1: List of transcripts significantly affected by ETS1 silencing in OCI-LY7. In order from the left column to the right column: the Illumina probes that were commonly regulated by both shRNAs for ETS1;

the official gene symbol; P value; fold change.

Table A2: List of transcripts significantly affected by FLI1 silencing in OCI-LY7. In order from the left column to the right column: the Illumina probes that were commonly regulated by both shRNAs for ETS1; the official gene symbol; P value; fold change.

Table A3: List of transcripts significantly affected by ETS1 silencing in SUDHL-4. In order from the left column to the right column: the Illumina probes that were commonly regulated by both shRNAs for ETS1;

the official gene symbol; P value; fold change.

Table A4: List of transcripts significantly affected by ETS1 silencing in SUDHL-2. In order from the left column to the right column: the Illumina probes that were commonly regulated by both shRNAs for ETS1;

the official gene symbol; P value; fold change.

Table A5: List of transcripts significantly affected by FLI1 silencing in SUDHL-4. In order from the left column to the right column: the Illumina probes that were commonly regulated by both shRNAs for ETS1; the official gene symbol; P value; fold change.

Table A6: List of transcripts significantly affected by FLI1 silencing in SUDHL-2. In order from the left column to the right column: the Illumina probes that were commonly regulated by both shRNAs for ETS1; the official gene symbol; P value; fold change.

Table A7: Lists of GSEA cp and cgp gene-sets found enriched in transcripts regulated by ETS1 silencing in OCI-LY7. First column, gene-set name; second column, normalized enrichment score (NES); third column, FDR q values; fourth column, rank.

Table A8: Lists of GSEA cp and cgp gene-sets found enriched in transcripts regulated by FLI1 silencing in OCI-LY7. First column, gene-set name; second column, normalized enrichment score (NES); third column, FDR q values; fourth column, rank.

Table A9: Lists of GSEA cp and cgp gene-sets found enriched in transcripts regulated byETS1 silencing in SUDHL-4. First column, gene-set name; second column, normalized enrichment score (NES); third column, FDR q values; fourth column, rank.

Table A10: Lists of GSEA cp and cgp gene-sets found enriched in transcripts regulated by FLI1 silencing in SUDHL-4. First column, gene-set name; second column, normalized enrichment score (NES); third column, FDR q values; fourth column, rank.

Table A11: Lists of GSEA cp and cgp gene-sets found enriched in transcripts regulated byETS1 silencing in SUDHL-2. First column, gene-set name; second column, normalized enrichment score (NES); third column, FDR q values; fourth column, rank.

Table A12: Lists of GSEA cp and cgp gene-sets found enriched in transcripts regulated by FLI1 silencing in

SUDHL-2. First column, gene-set name; second column, normalized enrichment score (NES); third column,

FDR q values; fourth column, rank.

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Table A1

Probe SYMBOL p-value(shETS1#1 and shETS1#2 vs. shGFP) Fold-Change(shETS1#1 and shETS1#2 vs. shGFP)

ILMN_1651254 LPP 1.48E-05 -1.37514

ILMN_1652825 IL10RA 6.85E-06 -1.22238

ILMN_1653319 MC1R 2.15E-04 1.25532

ILMN_1654210 CD1C 1.81E-03 -1.35071

ILMN_1654396 ITGB2 1.80E-05 -1.27393

ILMN_1656501 DUSP5 1.29E-04 -1.28822

ILMN_1657347 PODXL2 5.47E-05 1.22588

ILMN_1658071 ATP1B1 6.63E-04 1.23851

ILMN_1658182 MEX3C 1.45E-04 -1.25513

ILMN_1659027 SLC2A1 2.52E-05 -1.33711

ILMN_1659544 STX3 4.78E-03 -1.24346

ILMN_1660021 M6PRBP1 6.14E-06 -1.31554

ILMN_1660275 C2orf43 3.80E-07 -1.24637

ILMN_1660462 MCOLN2 1.18E-03 1.23069

ILMN_1660754 C13orf25 1.91E-03 1.31919

ILMN_1660793 PAQR4 1.82E-03 1.29771

ILMN_1660840 PPPDE1 6.17E-04 -1.26556

ILMN_1662070 HTR3A 1.24E-03 -1.27086

ILMN_1662617 PPP2R3C 9.67E-06 -1.24239

ILMN_1662658 PUS1 1.98E-04 1.20991

ILMN_1662799 GPSM3 2.81E-06 -1.2981

ILMN_1662843 CD53 5.01E-04 -1.22286

ILMN_1663916 ARHGAP9 2.69E-03 -1.23934

ILMN_1666553 SLC25A19 9.30E-04 1.20978

ILMN_1667030 HSBP1 1.35E-03 1.27591

ILMN_1667893 TNS3 1.69E-03 1.20227

ILMN_1668039 GYPC 5.00E-04 -1.29294

ILMN_1668277 BLK 9.00E-04 1.20727

ILMN_1669881 TSPAN13 1.50E-04 -1.42385

ILMN_1670193 ACY3 2.48E-03 -1.21817

ILMN_1670926 CHST15 5.42E-04 1.25858

ILMN_1671116 C3orf21 4.19E-04 1.24543

ILMN_1671509 CCL3 7.52E-04 -1.42362

ILMN_1672834 SSH2 4.64E-04 1.22441

ILMN_1673305 RHOC 4.91E-03 -1.21476

ILMN_1673352 IFITM2 3.68E-03 -1.21584

ILMN_1673450 DDN 8.67E-05 1.24201

ILMN_1674160 BIN1 2.12E-04 -1.21207

ILMN_1674386 PITX1 6.06E-05 1.26014

ILMN_1675191 GAPT 4.30E-03 -1.25271

ILMN_1675542 LOC729148 4.77E-03 1.20513

ILMN_1676358 RALB 6.13E-06 -1.22294

ILMN_1676393 ATP5G1 2.19E-07 2.12068

ILMN_1677827 TLR7 3.02E-06 1.28735

ILMN_1678766 DYNLT1 4.19E-04 -1.21425

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3

ILMN_1679041 SLC3A2 3.95E-03 -1.25815

ILMN_1680134 CARM1 1.28E-05 1.27913

ILMN_1680850 RECQL 5.23E-05 -1.21509

ILMN_1681340 C1orf41 5.52E-04 -1.43075

ILMN_1682332 GYPC 3.38E-03 -1.2808

ILMN_1682368 LRWD1 2.64E-03 1.2248

ILMN_1682567 CCDC106 1.42E-03 1.21321

ILMN_1683175 C9orf23 3.29E-03 1.2246

ILMN_1683475 TOMM40 8.49E-04 1.23703

ILMN_1683494 TMEM154 3.10E-05 -1.22808

ILMN_1684663 ZDHHC13 3.31E-05 -1.20253

ILMN_1687519 SNAP23 3.41E-03 1.22198

ILMN_1687538 ETS1 1.86E-10 -2.17786

ILMN_1688158 CYB5R4 1.01E-06 -1.38871

ILMN_1688279 PVRIG 4.57E-03 -1.24182

ILMN_1688464 MAP6D1 9.35E-05 1.22088

ILMN_1688526 ARL5A 9.33E-09 1.40282

ILMN_1688580 CAMP 1.62E-03 -1.27603

ILMN_1690386 CSRP2BP 2.63E-04 1.20986

ILMN_1690963 ASAP1 2.86E-05 -1.25464

ILMN_1691341 IL7R 4.84E-04 -1.20733

ILMN_1691402 LOC644162 3.51E-05 1.29722

ILMN_1692168 UBE2Z 4.26E-05 -1.23925

ILMN_1692219 RAB11FIP1 5.18E-06 -1.35381

ILMN_1692938 PSAT1 1.33E-03 -1.37343

ILMN_1693311 TMBIM6 8.91E-06 -1.2241

ILMN_1694106 GPD1L 6.68E-08 1.433

ILMN_1694385 YWHAB 1.11E-06 -1.45943

ILMN_1695658 KIF20A 1.01E-03 -1.29706

ILMN_1697363 C20orf27 4.56E-04 1.23028

ILMN_1697448 TXNIP 8.82E-04 -1.32541

ILMN_1697554 SASH3 1.36E-04 -1.27582

ILMN_1698189 AASDHPPT 2.79E-03 -1.20472

ILMN_1699931 HCST 8.00E-07 -1.35964

ILMN_1699991 LCK 5.75E-04 -1.24556

ILMN_1700257 C4orf32 8.95E-06 1.42673

ILMN_1700268 QPRT 1.02E-04 1.32338

ILMN_1702177 GLO1 6.69E-05 1.41505

ILMN_1702279 KIF3B 1.29E-04 -1.22814

ILMN_1705442 CMTM3 7.68E-06 -1.31746

ILMN_1705953 LONRF1 1.62E-04 -1.22193

ILMN_1706764 GOLPH3L 1.45E-04 -1.21981

ILMN_1707339 BTG3 1.35E-03 -1.21037

ILMN_1708151 LAGE3 2.33E-03 1.23553

ILMN_1711516 ATP6V1A 1.91E-06 -1.20734

ILMN_1712430 ATP5G1 2.04E-05 1.47324

ILMN_1712748 C14orf129 7.86E-04 -1.20343

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ILMN_1713266 FAM46C 7.46E-05 -1.2991

ILMN_1713505 NPC1 4.47E-06 -1.2638

ILMN_1715273 PICALM 6.90E-04 -1.2328

ILMN_1715583 BOP1 2.08E-04 1.23891

ILMN_1715603 IL23A 8.27E-05 -1.20292

ILMN_1715674 ITPK1 2.58E-08 1.33716

ILMN_1716272 KBTBD8 4.34E-03 -1.22118

ILMN_1716382 LOC387882 1.82E-03 -1.36654

ILMN_1718718 MKKS 7.87E-04 1.21261

ILMN_1718961 BNIP3L 8.83E-05 -1.48379

ILMN_1718972 MFSD3 1.36E-03 1.25427

ILMN_1719158 CTBP1 4.28E-05 1.20996

ILMN_1720858 C6orf115 1.83E-03 -1.21986

ILMN_1722309 ENDOG 5.75E-05 1.23583

ILMN_1722532 JMJD1A 8.34E-05 -1.21105

ILMN_1722533 KATNAL1 1.37E-03 -1.21724

ILMN_1722905 MRPS11 6.77E-05 1.21857

ILMN_1728106 TNF 1.03E-05 -1.21967

ILMN_1728535 COPZ1 8.41E-04 -1.25913

ILMN_1732089 MRI1 3.41E-05 1.286

ILMN_1732150 KIAA0101 2.26E-03 1.23238

ILMN_1733176 LIMS1 3.07E-03 -1.20777

ILMN_1733666 PLDN 4.19E-03 1.23901

ILMN_1733811 JUP 8.64E-05 -1.27446

ILMN_1736441 PDXP 7.60E-06 1.25787

ILMN_1736806 PAG1 2.79E-03 -1.22513

ILMN_1738529 BCS1L 2.73E-05 1.2532

ILMN_1738530 ATAD3A 2.78E-04 1.24498

ILMN_1738632 PRKAR1A 1.31E-03 -1.22019

ILMN_1739253 STAMBP 2.06E-03 -1.22559

ILMN_1740265 ACOT7 3.36E-05 1.30999

ILMN_1740512 MGC39900 2.82E-04 1.29718

ILMN_1740819 STARD7 2.39E-03 -1.22336

ILMN_1741477 SMAD4 5.62E-05 -1.24415

ILMN_1742789 LPXN 9.40E-05 -1.33751

ILMN_1743911 SLC25A39 1.12E-04 1.21037

ILMN_1744442 TTPAL 1.30E-04 -1.20045

ILMN_1744725 BTBD6 4.16E-07 1.27879

ILMN_1745471 IRF9 1.11E-04 -1.23563

ILMN_1745964 IRAK2 1.39E-07 -1.23444

ILMN_1747355 CCL3L1 6.44E-04 -1.462

ILMN_1747911 CDC2 2.38E-03 -1.31815

ILMN_1748093 PAFAH1B3 1.44E-03 1.32997

ILMN_1748827 LOC388564 5.76E-04 1.20377

ILMN_1748911 SNAP23 1.12E-03 1.3392

ILMN_1749634 PLRG1 3.45E-04 -1.20113

ILMN_1750181 TESC 1.46E-04 1.27804

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5

ILMN_1750722 RPS7 2.48E-03 1.2018

ILMN_1752046 SH2B3 4.52E-05 -1.30958

ILMN_1754114 FLJ20021 2.39E-04 1.26225

ILMN_1755405 FRAG1 5.83E-09 1.35154

ILMN_1756469 GAMT 4.62E-03 1.23404

ILMN_1756572 COQ2 4.35E-04 1.22134

ILMN_1756595 SH3TC1 1.29E-04 1.39235

ILMN_1756701 DHRS11 9.55E-07 1.32787

ILMN_1759075 TNFRSF13B 2.08E-03 1.23579

ILMN_1759729 NDUFA8 7.39E-06 1.2822

ILMN_1759766 CTXN1 7.67E-04 1.23079

ILMN_1761131 PECI 1.11E-03 -1.25936

ILMN_1761159 ESYT1 7.91E-06 -1.28123

ILMN_1762002 CSTF3 1.66E-04 1.21168

ILMN_1762312 FOXRED1 1.40E-03 1.20028

ILMN_1763000 ADAP2 2.83E-03 -1.21866

ILMN_1763666 ALDH3B2 1.61E-03 -1.24855

ILMN_1764207 RPRD1A 1.11E-03 1.30356

ILMN_1764410 C22orf13 1.59E-05 -1.24492

ILMN_1764522 LMBR1 2.07E-04 1.26255

ILMN_1764873 ELAVL1 3.94E-04 1.2787

ILMN_1765258 HLA-E 1.70E-04 -1.2086

ILMN_1768197 ROD1 1.57E-03 -1.20456

ILMN_1769245 GLIPR1 1.07E-05 -1.435

ILMN_1769575 JAM3 1.10E-03 1.22913

ILMN_1769634 STRA13 5.87E-05 1.32369

ILMN_1770084 TACC1 2.57E-04 -1.25721

ILMN_1770824 ARHGAP4 4.21E-04 1.22911

ILMN_1771264 ELL3 4.11E-03 1.22984

ILMN_1771738 ARL5A 2.57E-04 1.2639

ILMN_1773245 CCL3L1 1.85E-04 -1.35268

ILMN_1775448 PFN2 3.41E-06 1.38876

ILMN_1775708 SLC2A3 9.58E-05 -1.54132

ILMN_1776674 SAC3D1 4.99E-04 1.20542

ILMN_1777261 FAM3C 3.92E-04 -1.28416

ILMN_1777721 MAPRE1 4.90E-04 -1.30683

ILMN_1777998 ARHGAP25 2.41E-05 -1.24328

ILMN_1778561 WEE1 7.86E-05 -1.36669

ILMN_1778681 EBF1 1.57E-03 1.29505

ILMN_1779353 PUS7 2.60E-05 1.2586

ILMN_1780397 TRAF3IP3 2.83E-04 -1.20123

ILMN_1780582 CD83 4.12E-03 -1.2435

ILMN_1780773 LOC400027 1.78E-04 1.27014

ILMN_1782247 KAT2A 3.39E-03 1.20395

ILMN_1784709 GNPDA1 3.58E-05 -1.3231

ILMN_1785831 ZDHHC13 1.04E-06 -1.2109

ILMN_1788053 SLC25A12 1.51E-04 1.27214

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ILMN_1788108 TXNDC5 5.31E-04 1.22668

ILMN_1789233 VPS37C 4.49E-03 1.2433

ILMN_1789240 MLST8 2.68E-05 1.23729

ILMN_1790973 CDS2 1.06E-07 -1.28063

ILMN_1791296 DPY19L1 1.03E-04 -1.2842

ILMN_1791328 STK39 8.46E-10 1.61811

ILMN_1792075 CD22 5.12E-05 -1.20051

ILMN_1792508 TMEM59 4.10E-03 -1.2026

ILMN_1792587 VPS4B 3.04E-04 -1.20566

ILMN_1795298 GPER 6.87E-05 1.42193

ILMN_1795762 PLEK 4.83E-03 -1.39031

ILMN_1795811 ASB2 1.96E-03 -1.21287

ILMN_1795835 LOC338758 1.45E-05 1.43969

ILMN_1797604 CAP1 1.67E-05 -1.23365

ILMN_1797693 BRI3BP 1.46E-03 1.22205

ILMN_1798543 STK17B 2.07E-03 -1.21811

ILMN_1798657 TBL1XR1 6.41E-04 1.20309

ILMN_1798659 CCDC28A 5.11E-05 -1.27289

ILMN_1798826 MRPS25 1.50E-04 1.3372

ILMN_1799110 LOC651961 7.45E-04 -1.26794

ILMN_1799320 C9orf37 1.39E-03 1.27123

ILMN_1800619 BRI3BP 7.49E-05 1.28021

ILMN_1801121 SENP2 5.23E-04 -1.2902

ILMN_1801710 APBB1IP 5.75E-06 -1.46177

ILMN_1801928 YWHAZ 1.10E-04 -1.25295

ILMN_1802808 LOC654103 8.31E-06 1.3191

ILMN_1803073 DNAJC12 4.73E-04 -1.21297

ILMN_1803279 TMED5 3.93E-05 1.52179

ILMN_1803476 KCTD20 4.66E-03 -1.20392

ILMN_1804735 CBS 6.55E-04 1.23331

ILMN_1806486 LOC389137 1.01E-03 1.20011

ILMN_1807423 IGF2BP3 7.01E-04 -1.224

ILMN_1808226 RGS16 5.33E-06 -1.27246

ILMN_1810127 ZNF789 1.02E-05 1.22118

ILMN_1810275 SLC7A7 3.94E-04 -1.27001

ILMN_1811921 CSRP1 1.21E-03 -1.24761

ILMN_1813010 VTA1 8.94E-04 -1.20938

ILMN_1814247 TCFL5 1.24E-04 1.20242

ILMN_1839019 6.38E-05 -1.3324

ILMN_1846922 1.51E-03 1.27244

ILMN_1852793 2.02E-04 1.25802

ILMN_1859946 1.00E-04 -1.26063

ILMN_1865764 1.91E-03 -1.24583

ILMN_1869109 2.59E-05 1.36939

ILMN_1870111 4.10E-04 1.2158

ILMN_2043615 C17orf90 3.80E-04 1.27077

ILMN_2045419 BNIP3L 4.33E-03 -1.29581

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7

ILMN_2047511 CENTA1 2.05E-03 1.26401

ILMN_2055156 PAG1 2.04E-03 -1.23662

ILMN_2060413 CD24 2.98E-03 1.21612

ILMN_2069821 C4orf32 3.78E-03 1.22035

ILMN_2075927 STK40 4.61E-05 -1.2677

ILMN_2087702 MYH9 2.68E-03 -1.24671

ILMN_2088124 TMEM154 6.29E-05 -1.28083

ILMN_2096191 AASDHPPT 2.18E-04 -1.24209

ILMN_2101278 RGS18 1.64E-06 -1.35335

ILMN_2105033 PLDN 9.59E-04 1.24654

ILMN_2105573 CCL3L3 1.84E-04 -1.53596

ILMN_2108339 THUMPD1 1.01E-04 -1.22992

ILMN_2108735 EEF1A2 2.71E-04 1.25295

ILMN_2115633 CD320 9.60E-05 1.27012

ILMN_2120273 AP1S2 1.52E-03 1.24452

ILMN_2122103 ETS1 7.59E-10 -2.60114

ILMN_2122511 CCBE1 3.87E-03 1.23025

ILMN_2122952 CISD1 5.69E-04 1.21612

ILMN_2122953 CISD1 6.23E-04 1.20811

ILMN_2123567 SENP2 2.59E-05 -1.35384

ILMN_2126344 SEC16A 2.94E-05 -1.24691

ILMN_2129161 LRRC32 5.37E-04 -1.32554

ILMN_2130525 TSPAN13 4.68E-04 -1.31594

ILMN_2148668 RCBTB2 8.08E-04 -1.24943

ILMN_2151281 GABARAPL1 6.76E-05 -1.25365

ILMN_2157277 AKR1D1 8.73E-04 1.20841

ILMN_2157441 HLA-DRA 9.55E-06 -1.28143

ILMN_2162328 PTS 2.93E-05 1.22588

ILMN_2164164 AICDA 1.21E-04 1.448

ILMN_2173004 RAB8B 3.43E-06 -1.35215

ILMN_2174612 CNOT8 1.13E-06 -1.21426

ILMN_2175465 RSL24D1 4.58E-03 1.28737

ILMN_2175912 ITGB2 5.99E-04 -1.20069

ILMN_2191436 POLA1 9.26E-04 1.20891

ILMN_2192683 DHX37 2.50E-03 1.24506

ILMN_2193233 MGC29506 4.16E-05 1.31335

ILMN_2208903 CD52 4.81E-03 -1.27576

ILMN_2209180 P15RS 1.52E-06 1.61751

ILMN_2209748 DERL1 1.49E-03 -1.21042

ILMN_2213297 C11orf54 1.45E-06 -1.22461

ILMN_2216157 GNA12 1.60E-06 1.21645

ILMN_2218856 CCL3L1 3.08E-04 -1.4529

ILMN_2223805 TSGA14 3.24E-04 -1.22715

ILMN_2228732 CCNG2 3.29E-06 -1.32617

ILMN_2248589 DHX40 7.33E-04 -1.20572

ILMN_2255133 BCL11A 2.51E-03 1.30169

ILMN_2263718 SPAG9 9.64E-05 -1.24946

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8

ILMN_2264011 GRAP 5.46E-04 -1.24152

ILMN_2285996 KIAA0101 6.27E-05 1.34335

ILMN_2307740 CD46 2.80E-04 -1.31313

ILMN_2313730 RHOC 6.25E-04 -1.28431

ILMN_2313889 ZNF682 1.68E-03 1.22142

ILMN_2330243 NUDT1 1.94E-04 1.21008

ILMN_2330267 ABCE1 1.08E-03 -1.20422

ILMN_2332558 ARL5A 1.29E-07 1.62289

ILMN_2340259 PDE4B 6.37E-04 -1.22507

ILMN_2351298 WIPF1 4.17E-04 -1.26297

ILMN_2359789 RAC1 4.94E-06 -1.2601

ILMN_2363586 SDCBP 8.53E-05 -1.28987

ILMN_2364131 TTPAL 1.46E-08 -1.38094

ILMN_2367782 STARD7 4.59E-03 -1.2684

ILMN_2368773 FAM3C 4.06E-04 -1.28454

ILMN_2369580 C16orf35 7.21E-07 1.25288

ILMN_2370208 CMTM3 4.60E-05 -1.25489

ILMN_2371079 HTR3A 4.58E-03 -1.34526

ILMN_2374425 CCNE1 2.41E-04 1.22458

ILMN_2374770 TAX1BP1 1.72E-04 -1.20065

ILMN_2377109 LCK 8.41E-04 -1.2917

ILMN_2380999 RECQL 4.07E-04 -1.22698

ILMN_2384056 GPER 1.80E-04 1.55792

ILMN_2384536 PECI 3.15E-04 -1.31561

ILMN_2388155 CASP3 9.40E-06 -1.29345

ILMN_2388975 CERK 3.10E-03 1.24971

ILMN_2391355 STAMBP 1.72E-03 -1.20834

ILMN_2397880 CSTF3 9.24E-05 1.23874

ILMN_2407824 ATP1B1 1.20E-03 1.25931

ILMN_2409596 RAB11FIP1 8.21E-05 -1.23233

ILMN_2413808 CD53 1.78E-04 -1.26487

ILMN_2414027 CKLF 8.15E-04 -1.20678

ILMN_3182422 LOC100129828 7.16E-04 1.21218

ILMN_3220769 LOC729964 4.03E-04 -1.25506

ILMN_3230872 LOC728802 6.47E-04 -1.21481

ILMN_3238751 PMS2L4 1.30E-03 1.25084

ILMN_3238785 SNHG9 2.41E-04 1.26767

ILMN_3239343 STAG3L3 4.10E-03 1.23104

ILMN_3244114 DHRS11 6.01E-06 1.20816

ILMN_3244323 LOC148413 4.46E-03 1.2072

ILMN_3244693 LOC100130557 3.82E-04 1.32259

ILMN_3245057 ASAP1 4.74E-05 -1.23911

ILMN_3245869 LOC440957 1.55E-04 1.24961

ILMN_3246608 CENPV 1.26E-04 1.23123

ILMN_3251560 TMEM167A 4.81E-05 1.38695

ILMN_3273493 LOC100130092 3.35E-04 -1.33726

ILMN_3284114 LOC399748 3.70E-03 -1.26892

(10)

9

ILMN_3287266 LOC100133328 6.49E-04 1.21548

ILMN_3294365 LOC646993 2.61E-04 1.24221

ILMN_3301740 LOC729887 3.32E-05 1.32544

ILMN_3305735 LOC730101 2.43E-03 1.20926

Table A2

Probe SYMBOL p-value(shFLI1#1 and shFLI1#2 vs. shGFP) Fold-Change(shFLI1#1 and shFLI1#2 vs. shGFP)

ILMN_1652366 NLRP7 1.80E-03 1.71403

ILMN_1654518 LRCH4 6.38E-04 1.34343

ILMN_1657949 RHEB 8.31E-04 -1.3654

ILMN_1659415 MAP2K1IP1 1.46E-05 -1.33285

ILMN_1659845 KIAA0355 4.54E-05 -1.24003

ILMN_1660871 NEK6 3.35E-06 1.32617

ILMN_1662617 PPP2R3C 2.56E-04 -1.47694

ILMN_1664826 FBXO33 1.26E-05 -1.28411

ILMN_1665943 MAP4K1 1.66E-03 1.20427

ILMN_1665945 ACBD3 3.45E-05 -1.24993

ILMN_1667086 AP3M1 8.70E-04 -1.2525

ILMN_1668442 C21orf42 1.44E-03 -1.21239

ILMN_1670193 ACY3 1.26E-04 1.21833

ILMN_1672417 PTPRCAP 2.40E-04 1.43401

ILMN_1673252 AIMP2 1.82E-04 -1.27093

ILMN_1675542 LOC729148 3.08E-04 1.21545

ILMN_1676393 ATP5G1 4.52E-07 2.05367

ILMN_1676891 CDC2L6 4.00E-05 1.45791

ILMN_1677200 CYFIP2 6.02E-05 1.35693

ILMN_1679268 PELI1 6.31E-04 -1.39656

ILMN_1682264 DCAF7 1.42E-05 -1.25816

ILMN_1682572 KIAA0528 1.34E-04 1.27104

ILMN_1682727 JAZF1 8.09E-04 -1.24289

ILMN_1682953 PGAM4 1.26E-03 -1.68381

ILMN_1683664 LOC650369 4.29E-04 -1.22486

ILMN_1684042 BET1 1.43E-04 -1.30105

ILMN_1685124 TCTN1 8.35E-04 1.21827

ILMN_1688580 CAMP 1.66E-03 1.35746

ILMN_1691112 PIGN 3.19E-04 1.20255

ILMN_1694106 GPD1L 1.05E-04 1.31337

ILMN_1697742 C3orf38 9.11E-04 -1.30527

ILMN_1697962 NSMCE1 1.84E-05 1.20265

ILMN_1700001 TCTA 7.94E-04 1.26499

ILMN_1700257 C4orf32 2.88E-04 -1.42653

ILMN_1701289 MGC40489 1.06E-03 -1.26095

ILMN_1702835 SH3BGRL 5.27E-04 -1.29285

ILMN_1704342 UBE3C 1.43E-03 1.25149

ILMN_1706531 4.15E-04 1.30857

ILMN_1706841 PGAM4 1.42E-03 -1.61295

(11)

10

ILMN_1710326 CLDND1 1.93E-06 -1.35381

ILMN_1712430 ATP5G1 9.46E-04 1.37163

ILMN_1713380 EIF2B2 4.34E-04 -1.23391

ILMN_1715674 ITPK1 6.31E-07 1.35866

ILMN_1715702 LOC653171 6.28E-04 -1.20026

ILMN_1718297 EML4 9.77E-04 -1.24257

ILMN_1718718 MKKS 1.83E-05 1.28484

ILMN_1718972 MFSD3 1.02E-03 1.34491

ILMN_1719344 LOC730820 2.47E-04 -1.3331

ILMN_1719518 ARF4 1.01E-03 -1.21382

ILMN_1721128 TOMM34 1.24E-03 1.20673

ILMN_1721978 CARD11 1.78E-03 1.3008

ILMN_1723625 MAP4K2 9.81E-04 1.24518

ILMN_1724062 LIN54 1.18E-03 -1.20162

ILMN_1724811 PARN 2.08E-04 1.26198

ILMN_1725417 NELL2 1.01E-03 -1.22944

ILMN_1729019 SEPT7 1.51E-03 1.44088

ILMN_1729319 USP7 7.32E-05 1.2126

ILMN_1730612 DBNDD2 7.47E-04 1.33062

ILMN_1732967 KIAA1949 1.19E-05 -1.27827

ILMN_1733305 EIF2A 1.27E-03 -1.24745

ILMN_1736340 ANGEL2 3.22E-04 1.20138

ILMN_1736939 UGCG 1.24E-04 -1.20922

ILMN_1738179 FOXP1 1.56E-03 -1.24605

ILMN_1739770 CRSP9 1.12E-03 -1.20996

ILMN_1740772 APBB3 5.53E-04 1.22219

ILMN_1743582 NUDT22 6.18E-05 1.23226

ILMN_1744649 PSMB5 1.79E-05 -1.62244

ILMN_1745963 FOLR2 3.92E-05 1.30205

ILMN_1748481 TMEM199 7.62E-04 -1.20541

ILMN_1748827 LOC388564 3.39E-04 1.36575

ILMN_1751615 COQ10B 9.90E-05 -1.24905

ILMN_1754529 SPG7 1.80E-03 1.24031

ILMN_1755138 NEK8 5.32E-04 1.28488

ILMN_1755391 ARL2BP 2.96E-04 -1.2361

ILMN_1755405 FRAG1 8.05E-07 1.44578

ILMN_1758750 EARS2 5.49E-04 -1.23501

ILMN_1759075 TNFRSF13B 7.39E-04 1.27762

ILMN_1759097 MLLT11 2.46E-04 -1.36329

ILMN_1759359 BTF3L4 2.75E-07 -1.72953

ILMN_1759495 XPO5 4.86E-05 -1.29271

ILMN_1759729 NDUFA8 4.13E-04 1.20973

ILMN_1759915 ARPC1A 1.98E-04 -1.24108

ILMN_1759948 RNF5P1 3.33E-04 -1.46991

ILMN_1759983 DR1 1.13E-03 -1.3457

ILMN_1760347 SRGN 1.69E-03 -1.31692

ILMN_1761049 EIF2C3 7.53E-04 1.20558

(12)

11

ILMN_1761131 PECI 6.14E-04 -1.20862

ILMN_1761147 GABPB2 7.31E-04 -1.43072

ILMN_1761456 ALG13 8.63E-04 -1.20239

ILMN_1763198 STAT6 1.05E-03 1.24561

ILMN_1763404 LOC653226 1.41E-05 -1.42885

ILMN_1763638 BCAR3 1.93E-04 -1.2799

ILMN_1764410 C22orf13 3.62E-05 -1.23818

ILMN_1764522 LMBR1 2.38E-04 1.27519

ILMN_1764861 ISOC1 2.53E-04 -1.35612

ILMN_1764873 ELAVL1 6.74E-04 1.31625

ILMN_1765222 CARS2 8.60E-04 1.20379

ILMN_1766637 GLA 3.47E-05 -1.28896

ILMN_1768197 ROD1 6.38E-04 -1.2614

ILMN_1768751 MTA3 5.39E-04 -1.21944

ILMN_1769787 SELO 2.65E-04 1.24093

ILMN_1770623 FAM58A 2.67E-04 1.21585

ILMN_1770824 ARHGAP4 3.13E-04 1.34388

ILMN_1773313 USMG5 1.48E-03 -1.24547

ILMN_1773576 CPNE3 1.88E-04 -1.28511

ILMN_1773968 SERBP1 9.00E-04 -1.29281

ILMN_1777740 C8orf55 1.37E-03 1.46951

ILMN_1778173 AK3 1.08E-03 1.3291

ILMN_1778464 TMEM1 1.19E-03 1.20467

ILMN_1778668 TAGLN 5.17E-04 1.26713

ILMN_1778673 GOLGA7 3.81E-05 -1.27693

ILMN_1778803 ZFAND6 9.14E-05 -1.54746

ILMN_1779279 C14orf32 1.25E-03 -1.28533

ILMN_1782417 LOC651064 2.42E-06 1.28289

ILMN_1784040 NAPSA 1.09E-03 1.29426

ILMN_1785095 ATP6V0E2 1.15E-03 1.34301

ILMN_1791119 NDUFA10 2.90E-04 1.2253

ILMN_1791328 STK39 3.98E-07 1.54904

ILMN_1791826 RAB25 9.20E-05 1.48546

ILMN_1791827 LOC731878 2.40E-06 -1.25339

ILMN_1793894 ANAPC13 8.33E-08 -1.46888

ILMN_1796179 HIST1H2BK 4.26E-04 1.40509

ILMN_1797191 KIAA0040 2.74E-04 -1.27891

ILMN_1798620 PQLC1 8.31E-06 1.23108

ILMN_1798826 MRPS25 4.92E-04 1.24894

ILMN_1799642 TRIM24 4.23E-04 -1.25921

ILMN_1801605 BIRC6 7.36E-04 1.24886

ILMN_1802615 CDK6 3.21E-05 -1.41425

ILMN_1802669 PPP3CB 8.10E-04 1.2374

ILMN_1803073 DNAJC12 8.35E-05 -1.34224

ILMN_1803279 TMED5 1.34E-03 1.41375

ILMN_1803560 LAT2 1.48E-03 1.24217

ILMN_1803824 ZDHHC9 2.75E-04 -1.25619

(13)

12

ILMN_1807372 ADORA2A 1.14E-03 1.28955

ILMN_1811264 C15orf57 2.82E-04 -1.25448

ILMN_1811373 FAM20B 7.95E-05 -1.43261

ILMN_1814971 TCF25 5.94E-04 1.20015

ILMN_1832208 7.51E-05 -1.29139

ILMN_1839019 9.21E-04 -1.37777

ILMN_1847308 1.82E-04 1.21946

ILMN_1853876 6.30E-04 -1.34802

ILMN_1857915 LOC401397 4.74E-04 -1.36824

ILMN_1859127 1.56E-03 1.2355

ILMN_1859946 1.47E-03 -1.29188

ILMN_1869109 8.42E-04 1.2734

ILMN_1871457 1.31E-03 1.21569

ILMN_1911717 8.34E-04 1.20403

ILMN_2044927 RNF5 1.02E-07 -1.21626

ILMN_2049021 PTTG3P 1.95E-04 -1.30588

ILMN_2052863 RNF5P1 2.19E-04 -1.23897

ILMN_2054607 CYP4V2 1.59E-04 1.26625

ILMN_2061732 YRDC 5.15E-04 -1.39557

ILMN_2072140 BTF3L4 1.01E-04 -1.46307

ILMN_2075927 STK40 1.77E-03 -1.2207

ILMN_2078264 C3orf38 2.89E-04 -1.32402

ILMN_2093674 GMFB 1.82E-07 -1.42862

ILMN_2099594 SRP9 3.33E-05 -1.41888

ILMN_2101278 RGS18 9.41E-04 -1.41244

ILMN_2109416 NAPSB 1.05E-03 1.37928

ILMN_2115005 FGD2 5.90E-04 1.34919

ILMN_2115490 NBPF20 1.39E-03 1.28749

ILMN_2120273 AP1S2 5.99E-04 1.26921

ILMN_2125747 LOC606724 3.35E-05 1.38918

ILMN_2128795 LRIG1 6.23E-04 -1.28084

ILMN_2148796 MND1 1.43E-03 1.32063

ILMN_2150402 TMEM64 6.78E-04 -1.22689

ILMN_2156953 ZFAND6 1.49E-04 -1.33132

ILMN_2157075 LRCH4 1.22E-03 1.35948

ILMN_2161556 C12orf49 1.60E-03 -1.21783

ILMN_2173004 RAB8B 2.49E-06 -1.40202

ILMN_2179652 PRELID1 1.40E-04 1.2355

ILMN_2179726 C16orf93 6.69E-04 1.37445

ILMN_2181363 UBE3C 1.50E-03 1.23832

ILMN_2182198 ICT1 7.95E-04 -1.25885

ILMN_2188722 GLS 2.46E-04 1.37371

ILMN_2197365 RGS2 1.58E-04 -1.37172

ILMN_2203807 MRP63 1.63E-03 1.21286

ILMN_2209180 P15RS 1.19E-03 1.31563

ILMN_2209578 CTGLF3 1.31E-05 1.23158

ILMN_2214603 PPP2R3C 1.01E-04 -1.2666

(14)

13

ILMN_2228732 CCNG2 3.17E-05 -1.41991

ILMN_2230035 BBS2 1.60E-05 1.22447

ILMN_2282077 MIB2 8.86E-04 1.25402

ILMN_2332558 ARL5A 7.05E-04 1.31462

ILMN_2342033 F11R 9.73E-04 1.28036

ILMN_2342240 MGAT2 1.47E-03 -1.22468

ILMN_2352563 CLDND1 1.26E-06 -1.37381

ILMN_2356890 MRPL42 1.34E-04 -1.26472

ILMN_2356895 MRPL42 7.37E-04 -1.28907

ILMN_2362122 AP3M1 1.04E-03 -1.27192

ILMN_2370208 CMTM3 1.53E-03 -1.20218

ILMN_2376204 LTB 1.30E-05 1.95481

ILMN_2376205 LTB 1.47E-06 2.534

ILMN_2381753 G3BP2 6.01E-04 -1.3343

ILMN_2381758 G3BP2 1.20E-03 -1.38266

ILMN_2388800 PPAP2B 9.42E-05 -1.29395

ILMN_2394438 FAM177A1 4.27E-04 1.2028

ILMN_2394571 FBXW11 4.86E-04 -1.24749

ILMN_2407619 CDC25C 1.20E-03 -1.28055

ILMN_2407824 ATP1B1 1.13E-03 1.24135

ILMN_3178302 FNDC3B 5.57E-04 -1.26971

ILMN_3219806 LOC643384 1.59E-03 1.29678

ILMN_3229552 MED7 1.30E-05 -1.26038

ILMN_3234513 LOC728416 4.44E-04 1.2202

ILMN_3235472 WDYHV1 7.35E-05 -1.21497

ILMN_3242234 LOC100134018 3.10E-04 1.26912

ILMN_3244117 STMN3 4.70E-04 1.24181

ILMN_3248882 KIAA0114 2.11E-05 1.29016

ILMN_3249419 LOC728457 1.60E-03 1.25

ILMN_3253456 FNDC3B 1.19E-03 -1.23743

ILMN_3258795 FAM13B 9.84E-04 1.35494

ILMN_3272603 FAM60A 7.27E-04 -1.29156

ILMN_3306173 MED7 7.29E-04 -1.26436

Table A3

Probe SYMBOL p-value(shETS1#1 and shETS1#2 vs. shGFP) Fold-Change(shETS1#1 and shETS1#2 vs. shGFP)

ILMN_1651254 LPP 1.15E-03 -1.48474

ILMN_1651710 IQCD 4.01E-04 -1.24118

ILMN_1651826 BASP1 1.08E-02 -1.32273

ILMN_1652357 PDHX 3.68E-03 -1.27802

ILMN_1652394 RAB2A 1.23E-05 -1.31601

ILMN_1652407 ZMYND8 1.26E-03 1.22007

ILMN_1652521 MTMR9 1.60E-03 -1.20449

ILMN_1652722 C14orf2 5.88E-06 -1.3805

ILMN_1652806 ATP5J 7.85E-03 1.33021

ILMN_1653319 MC1R 3.98E-03 1.2637

(15)

14

ILMN_1653822 NEK2 1.97E-03 -1.27413

ILMN_1654210 CD1C 1.50E-03 -1.33366

ILMN_1654396 ITGB2 1.79E-04 -1.41066

ILMN_1654441 OAT 5.27E-04 1.52808

ILMN_1654541 ATP6V1G2 7.79E-04 1.26627

ILMN_1655046 NUTF2 2.71E-03 1.23748

ILMN_1655418 CAPNS1 1.31E-03 1.20838

ILMN_1655622 PRKRIR 4.00E-03 1.25238

ILMN_1655644 ZNF804A 3.45E-04 -1.29356

ILMN_1655922 SAPS2 2.66E-03 1.3224

ILMN_1656011 RGS1 4.24E-03 -1.52535

ILMN_1656233 LOC389517 2.80E-03 1.25405

ILMN_1656501 DUSP5 5.31E-03 -1.30117

ILMN_1657395 HMGCR 8.73E-04 -1.37003

ILMN_1657515 RPS6KA5 6.92E-03 -1.34022

ILMN_1657547 CCDC34 2.47E-03 -1.31348

ILMN_1657682 GFM1 3.50E-04 -1.25526

ILMN_1657760 SYT17 1.61E-03 1.26205

ILMN_1657983 TERF2IP 1.45E-03 1.57862

ILMN_1658027 RAD54L 9.60E-03 -1.21689

ILMN_1658494 C13orf15 4.58E-04 -1.2458

ILMN_1658678 SAAL1 3.21E-03 -1.30088

ILMN_1658695 NUF2 3.97E-03 -1.22338

ILMN_1658759 PEX19 6.47E-03 -1.32166

ILMN_1659027 SLC2A1 2.54E-03 -1.46662

ILMN_1659029 FAM116B 8.55E-03 1.28764

ILMN_1659463 APAF1 6.96E-03 -1.21919

ILMN_1659761 SNX29 6.67E-04 1.36778

ILMN_1659990 C7orf68 3.37E-03 1.2357

ILMN_1660086 MYH11 1.35E-04 1.22789

ILMN_1660275 C2orf43 6.28E-04 -1.33437

ILMN_1660341 LRPAP1 1.04E-02 1.2045

ILMN_1660749 ASPSCR1 5.32E-03 1.21323

ILMN_1660754 C13orf25 4.34E-03 1.27202

ILMN_1661554 DIAPH1 5.11E-04 -1.40765

ILMN_1661646 BANK1 6.45E-04 -1.3326

ILMN_1662038 LARGE 2.38E-03 1.23087

ILMN_1662070 HTR3A 2.29E-05 -1.85425

ILMN_1662799 GPSM3 1.52E-03 -1.34742

ILMN_1662843 CD53 4.26E-03 -1.26235

ILMN_1662878 PACAP 8.93E-03 1.27429

ILMN_1663538 CLYBL 5.05E-05 1.28514

ILMN_1663916 ARHGAP9 4.25E-04 -1.46838

ILMN_1664434 TCF3 1.09E-02 1.25556

ILMN_1664466 KLHL9 5.37E-03 -1.24059

ILMN_1664516 CENPF 1.06E-02 -1.21497

ILMN_1664630 CHEK1 7.00E-03 -1.25116

(16)

15

ILMN_1664641 MED4 5.33E-03 1.20761

ILMN_1664750 TMBIM4 9.18E-05 -1.23187

ILMN_1664833 MRPL50 5.13E-04 -1.20121

ILMN_1666364 COQ10A 4.41E-05 1.47985

ILMN_1666399 RING1 1.84E-03 1.22608

ILMN_1666546 DUSP14 1.50E-03 1.2164

ILMN_1666731 C3orf32 8.10E-04 1.22432

ILMN_1667030 HSBP1 3.81E-05 1.6002

ILMN_1667068 ZC3HAV1 2.14E-03 -1.23507

ILMN_1667086 AP3M1 9.59E-04 -1.23779

ILMN_1667295 VASN 3.98E-05 1.57388

ILMN_1667371 SLA 8.18E-03 1.28396

ILMN_1667519 RRAS2 7.30E-04 -1.59791

ILMN_1667670 SLC25A15 9.73E-03 -1.20432

ILMN_1667893 TNS3 2.98E-04 1.35192

ILMN_1668039 GYPC 9.91E-05 -1.52794

ILMN_1668540 ZNHIT6 3.41E-03 -1.21042

ILMN_1669142 NARG1 3.44E-03 -1.22147

ILMN_1669394 EI24 1.83E-03 -1.29412

ILMN_1669479 MEST 9.03E-03 -1.26361

ILMN_1669881 TSPAN13 4.12E-05 -1.76925

ILMN_1669982 CCDC85A 5.82E-04 1.25936

ILMN_1670145 DFNA5 5.07E-03 -1.28982

ILMN_1670193 ACY3 1.41E-03 -1.26101

ILMN_1670353 RAD51AP1 2.94E-03 -1.32415

ILMN_1670926 CHST15 8.04E-04 1.40777

ILMN_1671402 ARPP-21 5.84E-04 -1.33496

ILMN_1671509 CCL3 7.87E-03 -1.232

ILMN_1671554 LPIN1 5.78E-03 -1.23807

ILMN_1671911 MTA1 7.17E-03 1.31537

ILMN_1672004 TOB1 1.40E-03 1.23379

ILMN_1672097 CD86 5.76E-03 1.20052

ILMN_1672287 MYNN 7.19E-03 -1.21416

ILMN_1672405 TMED7 1.43E-03 -1.22529

ILMN_1672417 PTPRCAP 7.65E-03 -1.31616

ILMN_1672547 MYO9B 5.80E-03 1.26009

ILMN_1672605 C7orf41 1.89E-03 1.35565

ILMN_1672834 SSH2 1.22E-04 1.46528

ILMN_1673991 ATIC 9.65E-04 -1.23623

ILMN_1674063 OAS2 5.42E-04 -1.30202

ILMN_1674236 HSPB1 1.73E-04 1.81414

ILMN_1674983 LOC387841 9.23E-03 -1.22113

ILMN_1675191 GAPT 2.11E-05 -1.53276

ILMN_1675387 LIMS1 1.22E-03 -1.31012

ILMN_1675483 ANKMY1 6.22E-04 1.21353

ILMN_1676003 PNOC 9.17E-04 1.53666

ILMN_1676358 RALB 5.05E-04 -1.20291

(17)

16

ILMN_1676393 ATP5G1 6.36E-06 3.03503

ILMN_1676448 WDFY1 1.19E-04 1.29251

ILMN_1676523 CCDC91 3.90E-03 -1.37632

ILMN_1676799 MFAP1 4.88E-03 1.27939

ILMN_1676846 ABCE1 1.42E-03 -1.28041

ILMN_1676891 CDC2L6 2.17E-04 1.41767

ILMN_1677200 CYFIP2 2.09E-04 1.28312

ILMN_1677440 ATP6AP2 1.61E-03 -1.23715

ILMN_1677827 TLR7 2.84E-03 1.321

ILMN_1678669 RRM2 3.35E-03 -1.60969

ILMN_1679071 MTX3 1.17E-03 1.20975

ILMN_1679268 PELI1 8.36E-03 -1.30247

ILMN_1679438 MLF1IP 2.18E-03 -1.3317

ILMN_1679796 TOMM20 2.64E-03 -1.39164

ILMN_1679929 KLF13 1.65E-03 1.32331

ILMN_1679995 MPP6 5.95E-03 -1.25268

ILMN_1680037 FAM65A 1.07E-02 1.25185

ILMN_1680130 DYM 2.06E-03 1.26875

ILMN_1680134 CARM1 1.99E-04 1.50028

ILMN_1680390 GCNT2 6.27E-03 -1.20619

ILMN_1680419 ASB7 1.63E-03 -1.23652

ILMN_1680738 C5orf13 5.31E-03 1.30614

ILMN_1680850 RECQL 6.85E-03 -1.31677

ILMN_1681340 C1orf41 1.29E-04 -1.97546

ILMN_1681437 DCXR 2.60E-03 1.2851

ILMN_1682081 RNF19B 6.71E-03 -1.23081

ILMN_1682332 GYPC 3.84E-04 -1.48731

ILMN_1682402 SNORD46 1.41E-03 1.2051

ILMN_1682567 CCDC106 3.99E-03 1.35046

ILMN_1682694 LOC203547 6.11E-04 -1.27863

ILMN_1682727 JAZF1 8.16E-03 1.22651

ILMN_1682799 STAMBPL1 7.29E-05 -1.54547

ILMN_1683120 UNG 3.03E-03 -1.35603

ILMN_1683175 C9orf23 1.25E-04 1.41724

ILMN_1683194 DCN 9.44E-03 -1.24687

ILMN_1683450 CDCA5 4.08E-04 -1.28303

ILMN_1683933 SERPINA9 2.70E-04 -1.38155

ILMN_1683950 SNX11 1.63E-03 -1.20724

ILMN_1684045 CDCA4 9.28E-04 -1.27912

ILMN_1684289 PNPO 3.57E-04 -1.30525

ILMN_1684663 ZDHHC13 4.12E-03 -1.23744

ILMN_1685095 CNO 9.69E-04 1.20706

ILMN_1686319 USP37 1.01E-02 -1.24942

ILMN_1686610 APBA3 3.59E-03 1.24518

ILMN_1686805 CRK 9.32E-05 1.2335

ILMN_1687213 C8orf13 2.93E-03 1.24319

ILMN_1687384 IFI6 3.80E-03 -1.23781

(18)

17

ILMN_1687501 MOXD1 1.36E-03 -1.32456

ILMN_1687519 SNAP23 2.00E-05 1.61869

ILMN_1687538 ETS1 1.22E-03 -2.37743

ILMN_1687592 WWC3 6.94E-03 -1.26835

ILMN_1688158 CYB5R4 7.56E-04 -1.65427

ILMN_1688279 PVRIG 6.06E-05 -1.595

ILMN_1688526 ARL5A 8.72E-04 1.58585

ILMN_1688580 CAMP 7.43E-04 -1.41888

ILMN_1688775 METRNL 1.02E-02 1.21069

ILMN_1688853 ZBTB9 7.98E-04 -1.26584

ILMN_1688953 ARHGAP19 2.81E-03 -1.22042

ILMN_1689001 CDK4 5.67E-03 -1.20948

ILMN_1689110 NOB1 4.65E-03 1.21526

ILMN_1689655 HLA-DRA 2.36E-03 -1.31195

ILMN_1689720 PPP2R3B 5.20E-03 1.20873

ILMN_1689800 MRTO4 4.57E-03 -1.28547

ILMN_1690040 TM7SF2 1.84E-03 1.30978

ILMN_1690122 CRKL 1.04E-03 1.28825

ILMN_1690268 HNRPUL1 2.07E-04 1.30655

ILMN_1690454 C3orf54 2.90E-03 1.43726

ILMN_1690546 PPP3CC 8.13E-04 1.20737

ILMN_1690963 ASAP1 4.68E-04 -1.39673

ILMN_1691071 FCRLA 1.84E-03 -1.23927

ILMN_1691156 MT1A 4.11E-03 1.31339

ILMN_1691341 IL7R 6.75E-04 -1.25529

ILMN_1691364 STAT1 4.28E-05 -1.41197

ILMN_1691402 LOC644162 8.71E-05 1.53121

ILMN_1691572 TST 4.64E-03 1.20377

ILMN_1691693 FCRL3 5.55E-04 -1.68918

ILMN_1691717 RHBDF2 1.60E-03 1.41811

ILMN_1692072 LOC728006 7.06E-03 1.24687

ILMN_1692168 UBE2Z 4.48E-03 -1.37038

ILMN_1692219 RAB11FIP1 2.31E-03 -1.51375

ILMN_1692267 B4GALT3 4.53E-03 -1.26141

ILMN_1692705 RECQL 1.55E-03 -1.2117

ILMN_1692707 C2orf79 9.06E-04 1.2184

ILMN_1693220 AKAP11 2.67E-04 -1.29238

ILMN_1694027 SESN3 7.78E-03 -1.21866

ILMN_1694106 GPD1L 7.08E-04 1.59694

ILMN_1694174 TRIM68 5.03E-03 -1.2284

ILMN_1694240 MAP2K1 1.98E-04 1.36563

ILMN_1694268 HES6 3.26E-03 1.39632

ILMN_1694385 YWHAB 3.73E-05 -1.56262

ILMN_1694399 ICA1 4.55E-03 1.28643

ILMN_1694502 PRIM1 1.02E-02 -1.29318

ILMN_1694780 GCHFR 2.97E-03 1.33818

ILMN_1695316 SLC39A8 2.61E-03 -1.26164

(19)

18

ILMN_1695370 LOC645968 8.53E-04 1.21015

ILMN_1695658 KIF20A 4.86E-04 -1.43623

ILMN_1695917 C5orf15 1.30E-04 1.55171

ILMN_1695962 SLC12A9 2.42E-03 1.30707

ILMN_1696254 CYB5D2 4.65E-04 1.22407

ILMN_1697024 LOC730432 1.34E-04 -1.4455

ILMN_1697363 C20orf27 3.03E-03 1.20629

ILMN_1697448 TXNIP 1.89E-03 -1.53823

ILMN_1697460 REEP6 1.19E-03 1.23024

ILMN_1697554 SASH3 2.65E-04 -1.32802

ILMN_1697597 KIAA0494 7.57E-03 -1.20124

ILMN_1697864 CXorf38 3.59E-03 -1.33738

ILMN_1697962 NSMCE1 1.01E-02 1.23101

ILMN_1698189 AASDHPPT 2.18E-05 -1.33819

ILMN_1699503 UBE2D2 1.05E-02 1.29704

ILMN_1699631 GATS 2.64E-03 1.35251

ILMN_1699931 HCST 5.24E-03 -1.38005

ILMN_1699991 LCK 3.00E-04 -1.40892

ILMN_1700001 TCTA 3.39E-04 1.23376

ILMN_1700257 C4orf32 2.77E-04 1.7277

ILMN_1700268 QPRT 7.00E-03 1.28457

ILMN_1700549 ERLIN2 7.61E-04 -1.21509

ILMN_1700955 TCTEX1D2 7.60E-05 -1.25906

ILMN_1701247 LOC132241 4.94E-03 1.20464

ILMN_1701551 ABCA6 3.82E-04 -1.23684

ILMN_1702124 LNX2 6.03E-04 1.20003

ILMN_1702125 HOXB7 1.92E-04 -1.20217

ILMN_1702177 GLO1 8.85E-06 2.00083

ILMN_1702279 KIF3B 4.35E-03 -1.34432

ILMN_1702396 PACSIN2 2.44E-03 -1.26031

ILMN_1703335 LACTB 1.78E-03 1.20642

ILMN_1703433 PLSCR3 6.70E-03 1.21577

ILMN_1705111 FNDC3A 6.96E-03 1.21936

ILMN_1705114 NUMB 5.63E-03 1.22472

ILMN_1705144 ULK1 5.01E-03 1.22173

ILMN_1705213 TMBIM1 2.89E-03 1.30683

ILMN_1705261 CAPN1 5.42E-03 1.25012

ILMN_1705310 VEZF1 6.02E-04 1.25353

ILMN_1705442 CMTM3 2.56E-03 -1.25823

ILMN_1705469 RDH14 1.02E-02 -1.23265

ILMN_1705876 NAP1L1 3.17E-03 1.21559

ILMN_1705907 NUP153 1.20E-03 -1.21291

ILMN_1705985 PIGA 9.24E-04 -1.29451

ILMN_1706015 FAM43A 1.07E-02 1.21505

ILMN_1706553 SMG7 4.09E-03 -1.22268

ILMN_1706764 GOLPH3L 1.33E-05 -1.31988

ILMN_1707088 DENND2D 4.25E-03 -1.43368

(20)

19

ILMN_1707339 BTG3 3.56E-04 -1.51134

ILMN_1707434 LOC653778 9.30E-03 1.21242

ILMN_1707695 IFIT1 4.85E-03 -1.22312

ILMN_1707783 CCDC72 1.21E-03 1.24286

ILMN_1707858 H2AFZ 7.32E-04 -1.22313

ILMN_1708006 MICB 4.39E-03 -1.36459

ILMN_1708081 LCLAT1 4.86E-03 -1.22926

ILMN_1708151 LAGE3 3.73E-03 1.33974

ILMN_1708611 RDX 3.49E-03 1.22448

ILMN_1708798 EAF2 1.21E-04 -1.36872

ILMN_1708858 CSNK1E 6.29E-03 1.20393

ILMN_1708905 LOC374443 5.79E-03 -1.23752

ILMN_1709396 PDCD10 1.73E-03 -1.20601

ILMN_1710136 HDHD1A 1.91E-04 1.21203

ILMN_1710428 CDC2 6.34E-03 -1.47335

ILMN_1710873 ZNF330 5.39E-03 -1.25896

ILMN_1711005 CDC25A 3.45E-04 -1.46635

ILMN_1711383 STK4 2.14E-03 -1.2217

ILMN_1711516 ATP6V1A 2.25E-03 -1.26477

ILMN_1712019 ANKRD17 1.11E-04 -1.32423

ILMN_1712088 CLYBL 4.53E-03 1.23631

ILMN_1712298 ANKRD46 1.95E-03 -1.53054

ILMN_1712390 CUTA 9.02E-03 1.23549

ILMN_1712430 ATP5G1 2.93E-04 2.00063

ILMN_1712687 PAK2 4.22E-03 -1.23982

ILMN_1712705 RAB40C 3.82E-03 1.26402

ILMN_1713249 PHF19 1.61E-03 -1.26695

ILMN_1713266 FAM46C 5.59E-04 -1.26179

ILMN_1713380 EIF2B2 1.07E-03 -1.2124

ILMN_1713450 MYL6B 1.03E-02 1.30214

ILMN_1713505 NPC1 8.28E-05 -1.43064

ILMN_1713668 TSNAX 5.25E-03 1.22678

ILMN_1713993 UBAC2 2.91E-03 1.40847

ILMN_1714159 LUZP1 5.63E-04 -1.21466

ILMN_1714349 GLCE 5.03E-04 1.23857

ILMN_1714623 TOMM22 1.68E-04 -1.29972

ILMN_1714730 UBE2C 8.92E-03 -1.22231

ILMN_1715214 PTPN7 3.98E-04 -1.24412

ILMN_1715674 ITPK1 1.18E-04 1.45293

ILMN_1715680 NEIL2 1.42E-04 -1.20557

ILMN_1716089 KANK2 1.02E-03 1.3679

ILMN_1716272 KBTBD8 3.04E-03 -1.30996

ILMN_1716279 CENPE 8.72E-03 -1.29002

ILMN_1716382 LOC387882 1.99E-04 -1.64542

ILMN_1716583 NME7 2.03E-03 -1.29543

ILMN_1716733 MYOM2 1.05E-03 1.3347

ILMN_1717714 CDKN2A 7.71E-03 1.21143

(21)

20

ILMN_1717765 NUDT11 1.43E-03 1.31968

ILMN_1717934 SYT11 4.34E-03 1.27963

ILMN_1718265 ATG5 2.86E-03 -1.28894

ILMN_1718718 MKKS 2.64E-03 1.27498

ILMN_1718961 BNIP3L 2.65E-03 -1.40839

ILMN_1718972 MFSD3 3.42E-03 1.3061

ILMN_1719158 CTBP1 2.86E-07 1.25067

ILMN_1719694 LOC729446 5.68E-04 1.29473

ILMN_1720266 LOC91431 1.16E-03 -1.26282

ILMN_1721204 CSF2RA 8.22E-03 1.24556

ILMN_1721344 MOBKL2A 6.12E-04 -1.38012

ILMN_1721457 RANBP1 1.12E-03 -1.24043

ILMN_1721659 LOC643668 2.40E-03 -1.29516

ILMN_1721713 EXOSC9 2.80E-04 -1.20661

ILMN_1721921 BLMH 9.09E-03 -1.44361

ILMN_1722102 ANAPC11 9.04E-04 1.29334

ILMN_1722309 ENDOG 7.72E-03 1.29515

ILMN_1722491 APRT 4.34E-03 1.24301

ILMN_1722533 KATNAL1 7.06E-04 -1.52277

ILMN_1723116 AMFR 4.02E-03 1.32616

ILMN_1723520 CD1A 9.59E-05 -1.62162

ILMN_1723978 LGALS1 1.16E-03 1.246

ILMN_1724493 LYSMD2 6.50E-04 -1.21157

ILMN_1725170 LOC650557 1.83E-03 -1.3675

ILMN_1725417 NELL2 1.70E-03 -1.32455

ILMN_1725594 FAM188A 7.46E-04 -1.27205

ILMN_1725620 GGNBP2 1.51E-03 1.26545

ILMN_1725889 AFF2 5.82E-04 -1.25668

ILMN_1726138 EI24 1.06E-03 -1.26073

ILMN_1726359 NECAP1 1.76E-04 -1.22567

ILMN_1726388 ACBD7 4.40E-04 1.20335

ILMN_1727055 C12orf48 2.36E-03 -1.3702

ILMN_1727184 WDR36 6.79E-03 -1.24485

ILMN_1727309 FAM82A2 1.58E-03 -1.41605

ILMN_1727315 DENND1A 8.73E-04 -1.21975

ILMN_1727466 KCNMB4 9.30E-03 1.20846

ILMN_1727540 C1orf112 6.29E-03 -1.27721

ILMN_1727618 C8orf38 3.19E-03 -1.28776

ILMN_1728106 TNF 9.67E-03 -1.31069

ILMN_1728107 GNG7 3.41E-04 1.42679

ILMN_1729019 SEPT7 3.96E-03 1.64149

ILMN_1729217 FAM131A 8.15E-03 1.28346

ILMN_1730568 ZDHHC7 1.73E-03 1.25646

ILMN_1731001 ERICH1 2.07E-03 -1.35147

ILMN_1731107 CCDC92 6.93E-05 1.32895

ILMN_1731215 MYBPHL 1.18E-04 1.72452

ILMN_1731224 PARP9 2.40E-03 -1.26819

(22)

21

ILMN_1731928 LY9 3.99E-03 -1.30001

ILMN_1732060 ARHGAP1 3.22E-04 -1.32239

ILMN_1732150 KIAA0101 6.04E-03 1.26952

ILMN_1732516 KNTC1 1.52E-03 -1.2365

ILMN_1732926 PVT1 1.90E-03 1.20008

ILMN_1732988 KIAA1666 2.89E-04 1.53832

ILMN_1733176 LIMS1 1.42E-03 -1.50539

ILMN_1733318 TEX9 2.82E-04 -1.32633

ILMN_1733396 CDC25A 1.09E-02 -1.20101

ILMN_1733511 GOLGA3 2.32E-04 1.30095

ILMN_1733559 LOC100008589 1.01E-02 1.5548

ILMN_1733666 PLDN 6.75E-06 1.6961

ILMN_1733851 DACT3 4.51E-04 1.24606

ILMN_1734428 LSM12 4.02E-03 1.28227

ILMN_1735004 C4orf43 3.92E-04 1.23131

ILMN_1735052 ULK1 1.03E-02 1.21219

ILMN_1735180 NCSTN 8.44E-04 1.36572

ILMN_1735415 NUDT16L1 1.52E-03 1.42815

ILMN_1735552 KIF1B 1.49E-04 1.31871

ILMN_1736353 PSMC1 8.24E-05 -1.25525

ILMN_1736441 PDXP 9.14E-03 1.29089

ILMN_1736510 FOXN2 2.65E-03 1.31615

ILMN_1736548 PHACTR4 1.22E-03 -1.28087

ILMN_1736806 PAG1 1.01E-02 -1.4103

ILMN_1737184 CDCA7 9.74E-03 -1.24672

ILMN_1738179 FOXP1 2.85E-04 -1.20655

ILMN_1738549 VPREB1 7.84E-05 1.52667

ILMN_1738657 SATB2 5.23E-04 -1.33712

ILMN_1738678 C9orf130 7.52E-03 1.23142

ILMN_1738712 GPR180 5.23E-04 -1.35161

ILMN_1739008 ATG9A 2.17E-03 1.20302

ILMN_1739154 LSAMP 1.88E-03 -1.20936

ILMN_1739253 STAMBP 3.00E-04 -1.26604

ILMN_1739397 GLMN 5.41E-03 -1.21451

ILMN_1739423 RN7SK 1.51E-03 1.94678

ILMN_1739428 IFIT2 8.37E-04 -1.3156

ILMN_1739967 TBK1 1.67E-03 -1.22515

ILMN_1740265 ACOT7 1.17E-03 1.50558

ILMN_1740772 APBB3 7.30E-03 1.24796

ILMN_1740819 STARD7 3.35E-03 -1.3953

ILMN_1740861 DTWD1 5.88E-03 -1.20441

ILMN_1741477 SMAD4 6.10E-03 -1.27587

ILMN_1741801 CDC7 1.03E-02 -1.25964

ILMN_1741976 SMARCAD1 6.96E-04 -1.25212

ILMN_1742124 KIAA1128 2.06E-03 1.22604

ILMN_1742238 SET 1.29E-03 -1.21819

ILMN_1742250 CCNH 3.75E-03 -1.22535

(23)

22

ILMN_1742382 RIMS3 2.37E-04 1.54695

ILMN_1742789 LPXN 3.48E-04 -1.39795

ILMN_1743199 EGR2 5.48E-04 -1.53257

ILMN_1743205 ABCA7 2.03E-03 1.30629

ILMN_1743299 PXMP3 6.51E-04 -1.26414

ILMN_1743456 ZCCHC14 8.22E-05 1.27232

ILMN_1743499 POLDIP2 9.73E-05 -1.21179

ILMN_1744442 TTPAL 2.55E-05 -1.30436

ILMN_1744534 LYRM5 3.27E-04 1.48404

ILMN_1744647 CAND1 1.82E-03 -1.28753

ILMN_1744725 BTBD6 5.69E-04 1.40824

ILMN_1745130 RBM9 4.10E-03 -1.23408

ILMN_1745132 GDF11 1.19E-03 1.24797

ILMN_1745329 PRR14 4.75E-03 1.25989

ILMN_1745365 PKNOX1 2.07E-03 1.2126

ILMN_1746012 MBD6 2.22E-03 1.31364

ILMN_1746801 CGN 4.46E-03 1.22327

ILMN_1747058 TRAPPC2L 5.35E-04 1.36537

ILMN_1747183 GXYLT1 7.08E-03 -1.22866

ILMN_1747195 PSMB8 9.70E-04 -1.37333

ILMN_1747281 EVI5L 6.97E-04 1.28909

ILMN_1747355 CCL3L1 1.00E-03 -1.40262

ILMN_1747577 ALAD 3.62E-04 1.25012

ILMN_1747771 LOC730744 1.52E-04 1.2633

ILMN_1747911 CDC2 2.66E-04 -1.7389

ILMN_1748291 C1orf55 9.09E-03 -1.29154

ILMN_1748616 GTF2F1 1.01E-02 -1.23562

ILMN_1748650 MRPL45 6.64E-03 -1.21442

ILMN_1748827 LOC388564 3.24E-03 1.21731

ILMN_1748883 CDKN2D 1.08E-03 1.32096

ILMN_1748911 SNAP23 2.04E-03 1.50962

ILMN_1748926 TMEM209 2.54E-05 -1.45838

ILMN_1749109 PSAP 6.97E-03 1.22906

ILMN_1749521 SLC35E3 1.58E-03 1.25723

ILMN_1749591 ITGAL 1.08E-03 -1.288

ILMN_1749634 PLRG1 2.28E-03 -1.23642

ILMN_1749799 NSBP1 3.36E-04 -1.22936

ILMN_1749829 DLGAP5 2.69E-03 -1.24868

ILMN_1750395 MBD2 2.30E-04 -1.72156

ILMN_1751051 C7orf25 1.46E-03 1.29134

ILMN_1751773 POLD3 6.89E-03 -1.26373

ILMN_1751851 CECR1 1.31E-03 -1.26249

ILMN_1751898 C12orf4 2.13E-03 -1.29648

ILMN_1752046 SH2B3 4.74E-04 -1.51476

ILMN_1752117 TMEM55A 2.01E-03 -1.20415

ILMN_1752394 CCNB1IP1 1.07E-02 -1.31973

ILMN_1752591 LEPROTL1 9.42E-04 -1.27513

(24)

23

ILMN_1752899 BCL11A 3.90E-03 1.35967

ILMN_1753241 SNTA1 3.58E-04 1.39091

ILMN_1753279 HNRNPA0 2.16E-03 1.25151

ILMN_1753342 SAT1 5.63E-03 1.24457

ILMN_1753608 TMEM131 8.40E-05 1.58351

ILMN_1753613 HOXA5 8.90E-03 1.28702

ILMN_1754501 LOC339804 7.24E-03 1.2721

ILMN_1754531 AP4E1 4.18E-03 -1.28461

ILMN_1755303 ZNF217 2.30E-03 1.20852

ILMN_1755405 FRAG1 2.96E-04 1.45641

ILMN_1755537 EIF1AY 3.00E-03 -1.23925

ILMN_1755664 RPS26 1.78E-03 -1.25853

ILMN_1755882 C13orf7 1.01E-02 -1.20067

ILMN_1755926 DBI 2.81E-03 1.22527

ILMN_1755974 ALDOC 1.90E-03 1.38388

ILMN_1756052 NOL4 5.93E-03 -1.2578

ILMN_1756469 GAMT 1.45E-03 1.31755

ILMN_1756541 MXD4 5.00E-04 1.61366

ILMN_1756550 NUP62CL 1.69E-03 -1.30783

ILMN_1756595 SH3TC1 1.53E-04 1.23054

ILMN_1756701 DHRS11 3.28E-03 1.24519

ILMN_1756779 CLTC 4.10E-03 1.48339

ILMN_1757278 LOC643300 8.83E-03 -1.26883

ILMN_1757287 MAPK6 1.48E-04 1.30312

ILMN_1757388 OCEL1 1.81E-03 1.32756

ILMN_1757646 UFM1 6.27E-03 -1.22077

ILMN_1757877 HCFC1R1 9.85E-03 1.25192

ILMN_1758778 CEP110 4.58E-03 -1.25459

ILMN_1758816 UGT8 7.98E-04 -1.38481

ILMN_1758823 SMARCB1 4.30E-03 -1.32109

ILMN_1758939 RIPK2 2.60E-03 -1.30859

ILMN_1758941 REEP5 5.07E-03 -1.20122

ILMN_1759097 MLLT11 5.18E-04 -1.30278

ILMN_1759325 C16orf91 5.97E-03 1.21705

ILMN_1759729 NDUFA8 7.89E-03 1.34976

ILMN_1759915 ARPC1A 9.01E-03 1.22013

ILMN_1760335 ADPRHL1 1.33E-03 -1.27728

ILMN_1760718 ZMIZ2 7.49E-04 1.33096

ILMN_1761131 PECI 3.65E-03 -1.40045

ILMN_1761260 COBLL1 2.13E-03 -1.28117

ILMN_1761277 PDE4C 1.81E-03 1.25367

ILMN_1761463 EFHD2 3.07E-03 1.31807

ILMN_1761733 HLA-DMB 1.78E-03 -1.27581

ILMN_1762308 LOC654191 1.12E-03 1.31205

ILMN_1762622 FAM111B 3.25E-03 -1.22394

ILMN_1763000 ADAP2 1.38E-04 -1.24795

ILMN_1763007 HIAT1 9.21E-03 -1.23952

(25)

24

ILMN_1763605 DIDO1 3.03E-03 1.21556

ILMN_1763638 BCAR3 3.60E-04 -1.20213

ILMN_1763688 C17orf49 5.80E-04 1.28644

ILMN_1763694 RSPRY1 8.69E-03 1.26253

ILMN_1764207 RPRD1A 4.93E-04 1.81306

ILMN_1764500 C3orf10 7.70E-03 1.20803

ILMN_1764522 LMBR1 6.67E-03 1.41421

ILMN_1764628 LYPLA2 3.95E-03 -1.20945

ILMN_1764861 ISOC1 7.92E-04 -1.32798

ILMN_1764873 ELAVL1 6.39E-05 1.66223

ILMN_1765520 MTIF2 6.88E-06 -1.23518

ILMN_1765684 C19orf70 8.47E-04 1.25411

ILMN_1766024 PDCD10 4.45E-03 -1.20456

ILMN_1766411 AP1S2 4.53E-05 1.44056

ILMN_1766797 CCS 1.05E-03 1.23004

ILMN_1766851 TMEM126B 3.59E-04 -1.22897

ILMN_1767448 LHFP 3.03E-04 -1.295

ILMN_1767470 SCPEP1 2.81E-03 1.25851

ILMN_1767475 CERK 5.84E-06 1.53295

ILMN_1767837 GOLT1B 2.29E-03 -1.34322

ILMN_1767892 DUSP12 7.59E-03 -1.209

ILMN_1768016 TNFRSF17 1.15E-04 -1.24529

ILMN_1768197 ROD1 1.04E-02 -1.25601

ILMN_1768804 LOC644014 2.26E-03 -1.22094

ILMN_1768816 TMPO 4.61E-03 -1.24034

ILMN_1768867 AP3B1 5.78E-04 1.28598

ILMN_1769135 DPP7 6.09E-04 1.22868

ILMN_1769245 GLIPR1 1.80E-03 -1.25514

ILMN_1769508 PIGX 2.68E-04 1.29555

ILMN_1769520 UBE2L6 5.13E-03 -1.21888

ILMN_1769634 STRA13 8.08E-03 1.21394

ILMN_1769671 RYK 2.26E-04 1.44672

ILMN_1769720 STAU2 5.26E-03 -1.255

ILMN_1769911 SLC38A1 1.50E-05 -1.389

ILMN_1770084 TACC1 1.77E-05 -1.45229

ILMN_1770623 FAM58A 2.74E-04 1.35127

ILMN_1770768 SLAMF1 1.34E-03 -1.3155

ILMN_1771264 ELL3 1.04E-02 1.26746

ILMN_1771376 PEA15 8.90E-04 1.28505

ILMN_1771627 ZMIZ1 3.79E-03 1.28086

ILMN_1771738 ARL5A 2.20E-04 1.50472

ILMN_1772207 LOC653377 6.37E-03 1.24184

ILMN_1772218 HLA-DPA1 5.27E-04 -1.25555

ILMN_1772261 GLG1 7.15E-03 1.2466

ILMN_1772302 MTHFS 2.19E-04 -1.31373

ILMN_1772522 ZFP161 3.45E-05 -1.23705

ILMN_1772627 D4S234E 5.71E-03 -1.2141

(26)

25

ILMN_1772644 EML3 1.24E-03 1.34266

ILMN_1772981 EPN1 1.61E-05 1.24762

ILMN_1773119 CCNF 2.27E-03 -1.37642

ILMN_1773200 CP110 2.17E-03 -1.2259

ILMN_1773245 CCL3L1 6.33E-04 -1.51263

ILMN_1773388 C13orf18 5.50E-03 1.22216

ILMN_1773427 KANK1 1.01E-03 -1.29847

ILMN_1773493 TIMM23 9.16E-03 -1.21421

ILMN_1773650 LRRN3 1.91E-03 -1.24177

ILMN_1773760 PAICS 4.52E-05 -1.24253

ILMN_1774387 ZHX3 1.25E-03 1.29149

ILMN_1774604 PNKD 1.28E-03 -1.25587

ILMN_1774844 MAPKAPK2 8.06E-04 -1.22947

ILMN_1775170 MT1X 2.77E-04 1.4859

ILMN_1775448 PFN2 1.39E-04 1.72447

ILMN_1775708 SLC2A3 1.79E-04 -1.73481

ILMN_1775743 BTG1 5.75E-03 1.24364

ILMN_1775759 NRAS 7.35E-03 -1.21343

ILMN_1776674 SAC3D1 3.74E-03 1.24835

ILMN_1776858 DUS4L 1.50E-04 -1.20641

ILMN_1777049 ZNF160 3.47E-03 1.22564

ILMN_1777261 FAM3C 4.52E-05 -1.5082

ILMN_1777721 MAPRE1 1.82E-04 -1.36052

ILMN_1777740 C8orf55 1.80E-03 1.21039

ILMN_1777881 TSPAN17 3.65E-03 1.31757

ILMN_1777998 ARHGAP25 4.20E-04 -1.37271

ILMN_1778173 AK3 7.36E-03 1.20897

ILMN_1778240 GFOD1 2.95E-03 1.20367

ILMN_1778242 CALM1 3.43E-03 1.24224

ILMN_1778321 SLC2A6 3.06E-03 1.35808

ILMN_1778360 PYGB 1.02E-02 1.26463

ILMN_1778561 WEE1 4.87E-04 -1.57845

ILMN_1778599 SP140 1.01E-03 -1.22633

ILMN_1778611 GBAS 9.76E-03 -1.22372

ILMN_1778677 MRS2 3.58E-04 -1.25423

ILMN_1778917 CDK7 3.77E-03 -1.25796

ILMN_1778991 NFIB 1.23E-03 1.23547

ILMN_1779014 TSPYL1 9.07E-03 1.20467

ILMN_1779163 C11orf67 3.21E-03 1.25739

ILMN_1779374 AMMECR1 1.14E-03 1.22406

ILMN_1779886 TBC1D14 1.40E-03 1.2148

ILMN_1780057 RENBP 8.01E-03 1.20028

ILMN_1780368 GPR18 1.01E-03 -1.21271

ILMN_1780397 TRAF3IP3 2.45E-03 -1.22775

ILMN_1780582 CD83 7.71E-03 -1.39993

ILMN_1780667 WDR51A 8.24E-03 -1.20466

ILMN_1780773 LOC400027 1.27E-04 1.49686

(27)

26

ILMN_1780861 LOC653506 1.07E-04 1.26075

ILMN_1781010 ARHGEF3 3.84E-04 -1.39293

ILMN_1781986 UCRC 1.08E-02 1.27963

ILMN_1782129 ZBED4 1.17E-03 1.23727

ILMN_1782403 PRR11 8.63E-05 -1.44267

ILMN_1783675 ASB8 6.79E-04 1.23826

ILMN_1783681 MRPL34 8.01E-03 1.22246

ILMN_1783889 PRKAA1 3.29E-06 -1.25573

ILMN_1784630 KBTBD11 3.14E-04 1.41319

ILMN_1784641 NDUFA3 3.89E-04 1.28219

ILMN_1784709 GNPDA1 3.77E-05 -1.27184

ILMN_1784860 RFC3 3.61E-03 -1.25611

ILMN_1785175 SWAP70 6.82E-03 -1.21959

ILMN_1785831 ZDHHC13 2.42E-03 -1.30934

ILMN_1786065 UHRF1 1.77E-03 -1.40553

ILMN_1786612 PSME2 1.79E-03 -1.22806

ILMN_1786658 BOLA3 1.47E-05 -1.52794

ILMN_1787308 PIP4K2C 4.90E-03 -1.21895

ILMN_1787762 HEATR1 3.79E-03 -1.20591

ILMN_1788040 ZPBP2 1.06E-03 -1.2105

ILMN_1788053 SLC25A12 2.30E-03 1.33273

ILMN_1788108 TXNDC5 7.64E-04 1.29308

ILMN_1788347 KIAA1737 3.04E-04 1.25047

ILMN_1788384 C9orf5 1.79E-04 -1.41084

ILMN_1788416 FAM108C1 5.24E-03 1.21917

ILMN_1788604 WBP2 1.85E-03 1.22065

ILMN_1788955 PDLIM1 8.22E-04 -1.2952

ILMN_1789136 SERF2 2.93E-03 1.28852

ILMN_1789233 VPS37C 2.03E-03 1.52174

ILMN_1789240 MLST8 1.56E-03 1.30564

ILMN_1789364 ZNF789 5.40E-04 1.3171

ILMN_1789999 SLC30A7 3.51E-03 -1.20405

ILMN_1790354 RABGGTB 4.05E-04 -1.21076

ILMN_1790461 C6orf125 3.41E-03 1.22942

ILMN_1790575 METTL13 1.48E-03 1.20781

ILMN_1790819 LOC728556 8.04E-03 1.31714

ILMN_1790953 TBCB 7.39E-03 1.32594

ILMN_1790973 CDS2 2.30E-03 -1.32999

ILMN_1791147 YPEL3 4.08E-03 1.37623

ILMN_1791226 NXN 9.91E-04 1.21144

ILMN_1791296 DPY19L1 4.23E-04 -1.49509

ILMN_1791328 STK39 3.87E-06 1.87229

ILMN_1791726 TUBB3 4.24E-03 1.2089

ILMN_1791840 RALBP1 6.90E-03 -1.22171

ILMN_1792508 TMEM59 2.43E-03 -1.31749

ILMN_1792671 C12orf29 1.15E-03 -1.26183

ILMN_1792825 ARIH2 4.30E-03 1.32074

(28)

27

ILMN_1792959 KCNMB2 1.35E-03 -1.2408

ILMN_1793033 RBM28 1.15E-04 -1.21188

ILMN_1793146 CCDC25 1.21E-03 -1.31999

ILMN_1793410 SNTB1 1.32E-03 1.27132

ILMN_1793517 RASAL1 3.22E-05 1.21347

ILMN_1793616 RNF38 4.39E-03 1.23685

ILMN_1793724 C3orf31 1.51E-03 -1.25936

ILMN_1793934 PISD 5.06E-03 -1.21476

ILMN_1794595 GAMT 1.38E-03 1.36609

ILMN_1795298 GPER 6.04E-05 1.69001

ILMN_1795383 RPUSD3 3.69E-03 1.25121

ILMN_1795464 LTA 3.07E-03 -1.27837

ILMN_1795762 PLEK 1.92E-04 -1.6624

ILMN_1795835 LOC338758 4.85E-03 1.27566

ILMN_1796074 C18orf56 1.82E-03 1.2916

ILMN_1796113 BCDIN3D 5.96E-03 1.30532

ILMN_1796464 WDR37 1.01E-02 -1.20743

ILMN_1796751 KIAA1274 3.26E-03 -1.21656

ILMN_1797191 KIAA0040 6.94E-04 -1.20781

ILMN_1797209 TSGA14 2.44E-03 -1.32601

ILMN_1797341 ARID1A 1.01E-04 1.49644

ILMN_1797384 UROS 4.13E-03 1.22219

ILMN_1797428 FCRL3 4.33E-05 -1.48517

ILMN_1797604 CAP1 3.98E-03 -1.20683

ILMN_1797728 HMGCS1 6.22E-04 -1.46268

ILMN_1797903 ZNF544 2.65E-03 -1.22512

ILMN_1797964 ARL6IP6 1.51E-04 -1.34412

ILMN_1798543 STK17B 1.08E-03 -1.43332

ILMN_1798620 PQLC1 3.49E-04 1.42239

ILMN_1798657 TBL1XR1 3.68E-04 1.40775

ILMN_1798659 CCDC28A 6.28E-03 -1.35878

ILMN_1798826 MRPS25 3.12E-04 1.40004

ILMN_1799667 KIF4A 1.48E-03 -1.21864

ILMN_1799688 CDC23 7.78E-03 -1.21039

ILMN_1800078 LMO2 3.68E-03 -1.35899

ILMN_1800390 ZNF511 9.35E-04 -1.20583

ILMN_1800619 BRI3BP 9.04E-03 1.23759

ILMN_1800837 CFDP1 1.77E-03 1.40476

ILMN_1800958 ALS2CR4 4.05E-03 -1.27855

ILMN_1800975 PSME3 3.68E-03 -1.29179

ILMN_1801101 ZBTB48 5.67E-03 1.20646

ILMN_1801121 SENP2 1.80E-05 -1.57985

ILMN_1801124 KIAA1826 2.23E-03 -1.20638

ILMN_1801710 APBB1IP 1.55E-04 -1.63868

ILMN_1801767 ABHD3 1.11E-03 1.32475

ILMN_1801833 ARHGAP24 9.64E-04 -1.23808

ILMN_1802027 MGST2 3.98E-03 -1.33803

(29)

28

ILMN_1802203 ARF1 8.90E-03 -1.296

ILMN_1802519 VPS36 2.24E-03 -1.2016

ILMN_1802615 CDK6 8.83E-06 -1.402

ILMN_1802669 PPP3CB 6.61E-03 1.2447

ILMN_1802808 LOC654103 5.58E-04 1.35207

ILMN_1802831 MTMR12 1.03E-03 -1.30372

ILMN_1803073 DNAJC12 5.86E-04 -1.31107

ILMN_1803194 GALK1 4.18E-03 1.20353

ILMN_1803197 RAB3IP 5.21E-03 -1.27155

ILMN_1803279 TMED5 3.81E-05 2.06116

ILMN_1803302 CRK 1.08E-02 1.23094

ILMN_1803392 TAX1BP3 1.74E-04 1.5132

ILMN_1803423 ARHGEF6 2.80E-04 -1.35526

ILMN_1803476 KCTD20 8.23E-03 -1.3021

ILMN_1803686 ADA 8.67E-06 1.23179

ILMN_1803838 CNFN 6.03E-04 1.26472

ILMN_1803941 TBC1D15 1.10E-02 -1.2113

ILMN_1804735 CBS 8.66E-03 1.20672

ILMN_1805064 SCARNA9 7.71E-03 1.22913

ILMN_1806040 TYMS 1.34E-03 -1.2761

ILMN_1806486 LOC389137 2.83E-03 1.30337

ILMN_1807106 LDHA 2.97E-05 -1.27007

ILMN_1807201 FAM104A 1.53E-03 1.25688

ILMN_1807423 IGF2BP3 3.60E-04 -1.40648

ILMN_1807492 LOC643668 9.54E-03 -1.21715

ILMN_1808226 RGS16 2.37E-04 -1.3624

ILMN_1808305 RTCD1 2.33E-03 -1.35501

ILMN_1808356 FAM3A 2.61E-03 1.23862

ILMN_1808405 HLA-DQA1 5.94E-03 -1.30586

ILMN_1808584 FAM36A 2.76E-03 1.20545

ILMN_1808634 TMEM77 4.00E-03 -1.32133

ILMN_1809352 PRL 1.25E-04 -1.42483

ILMN_1809817 FLJ23834 8.44E-05 1.32388

ILMN_1809894 TMEM117 2.48E-03 1.23759

ILMN_1810214 JUND 2.94E-03 1.29714

ILMN_1810275 SLC7A7 3.38E-04 -1.48171

ILMN_1810327 HNRPUL2 2.32E-06 1.30304

ILMN_1810838 MTDH 1.82E-03 -1.28578

ILMN_1811050 CCDC88A 2.36E-03 1.26009

ILMN_1811551 DERA 2.70E-05 1.29507

ILMN_1811574 MAPK8IP3 2.95E-03 1.31479

ILMN_1811702 GRN 9.71E-03 1.23274

ILMN_1811836 DYNC2LI1 1.08E-02 -1.22614

ILMN_1811921 CSRP1 4.94E-03 -1.29786

ILMN_1812250 LOC644642 7.57E-03 1.22776

ILMN_1812278 LY9 3.38E-04 -1.29446

ILMN_1812776 FBXO28 2.83E-03 1.26364

(30)

29

ILMN_1812856 ZSWIM1 1.54E-03 1.26142

ILMN_1813010 VTA1 4.86E-05 -1.47682

ILMN_1813581 CNR1 1.71E-04 1.33883

ILMN_1814039 LOC653086 2.51E-03 1.23677

ILMN_1814194 TCF4 6.45E-03 1.22101

ILMN_1814213 PQLC3 1.63E-03 1.31101

ILMN_1814247 TCFL5 3.12E-03 1.36684

ILMN_1814305 SAMD9 3.22E-03 -1.25263

ILMN_1815086 NINJ1 1.12E-04 1.34432

ILMN_1821280 1.60E-03 1.4642

ILMN_1821531 1.03E-03 -1.36905

ILMN_1832208 4.39E-03 -1.22994

ILMN_1839019 2.42E-04 -1.5861

ILMN_1846922 1.23E-03 1.4315

ILMN_1847308 2.89E-03 1.3925

ILMN_1848552 2.31E-04 1.42055

ILMN_1851547 6.71E-06 1.26678

ILMN_1853876 8.29E-04 -1.32306

ILMN_1856480 3.69E-05 1.26469

ILMN_1857915 LOC401397 5.68E-03 -1.37509

ILMN_1859946 4.80E-03 -1.34797

ILMN_1865764 2.80E-03 -1.3324

ILMN_1869109 1.63E-03 1.55229

ILMN_1873034 4.49E-04 -1.32217

ILMN_1877068 5.29E-03 -1.20123

ILMN_1880406 1.61E-03 -1.23835

ILMN_1884750 5.65E-03 1.24019

ILMN_1891857 4.60E-03 -1.31928

ILMN_1898723 2.57E-04 1.22334

ILMN_1901769 6.75E-04 1.28426

ILMN_1908824 1.73E-04 1.60383

ILMN_1912662 1.64E-04 1.21269

ILMN_2038775 TUBB2A 1.56E-04 1.25988

ILMN_2041046 CKS1B 2.16E-03 -1.31061

ILMN_2043079 ILDR1 1.33E-03 -1.30773

ILMN_2043615 C17orf90 1.79E-04 1.3353

ILMN_2044085 RQCD1 1.33E-03 -1.32721

ILMN_2045419 BNIP3L 7.57E-03 -1.28491

ILMN_2045911 FBXO28 2.37E-03 1.26658

ILMN_2051373 NEK2 2.68E-03 -1.54394

ILMN_2051684 LOC401152 1.83E-05 1.39435

ILMN_2051867 PTCD2 5.61E-05 -1.28238

ILMN_2053527 PARP9 5.83E-03 -1.2202

ILMN_2055156 PAG1 1.70E-03 -1.49711

ILMN_2059294 RTCD1 3.00E-03 -1.23384

ILMN_2059505 ARPP19 1.65E-03 -1.23154

ILMN_2059549 SYK 4.37E-03 -1.34579

(31)

30

ILMN_2060413 CD24 2.72E-06 1.55233

ILMN_2061452 ORC2L 2.16E-03 -1.24266

ILMN_2068747 OAT 4.22E-03 1.55851

ILMN_2069821 C4orf32 5.91E-03 1.33995

ILMN_2070210 RNF219 1.63E-04 -1.25886

ILMN_2071937 ATP6V0E1 9.42E-03 1.22336

ILMN_2072091 HNRNPUL2 1.06E-03 1.23703

ILMN_2073604 EBP 6.03E-03 -1.24108

ILMN_2074860 RN7SK 2.95E-04 2.08516

ILMN_2075927 STK40 4.81E-05 -1.31921

ILMN_2077623 RRAS2 2.71E-05 -1.58009

ILMN_2079098 C9orf80 4.35E-03 1.25834

ILMN_2081335 C7orf44 1.78E-03 1.22221

ILMN_2081398 KIF3B 6.59E-04 -1.26508

ILMN_2081682 SMAP2 2.19E-03 1.35181

ILMN_2087702 MYH9 9.97E-04 -1.23986

ILMN_2092693 LSM12 1.46E-03 1.2495

ILMN_2093500 ZBED5 3.19E-03 1.20493

ILMN_2096191 AASDHPPT 4.22E-03 -1.30557

ILMN_2097858 KIAA1737 2.14E-04 1.24371

ILMN_2101278 RGS18 2.07E-03 -1.34209

ILMN_2101526 GGCT 2.96E-03 -1.32402

ILMN_2103761 TLE4 1.36E-04 1.21207

ILMN_2104696 ERICH1 1.66E-03 -1.29695

ILMN_2104830 ACP2 3.74E-04 -1.21735

ILMN_2105033 PLDN 6.90E-03 1.45235

ILMN_2105253 PTGR2 2.77E-03 1.22137

ILMN_2105573 CCL3L3 6.13E-05 -1.69908

ILMN_2106658 BLZF1 6.24E-03 1.21635

ILMN_2108339 THUMPD1 4.89E-04 -1.39079

ILMN_2108735 EEF1A2 2.25E-04 1.46604

ILMN_2111187 ELOVL6 4.98E-03 -1.26422

ILMN_2116639 TFDP2 1.10E-02 1.22625

ILMN_2116714 SLC39A1 6.60E-03 -1.21412

ILMN_2119555 TMTC3 2.36E-03 1.20684

ILMN_2120273 AP1S2 2.41E-04 1.43256

ILMN_2122103 ETS1 1.17E-06 -3.0293

ILMN_2122374 FAM49B 8.94E-03 1.3495

ILMN_2122952 CISD1 2.51E-04 1.2582

ILMN_2123567 SENP2 4.63E-04 -1.6739

ILMN_2126344 SEC16A 1.08E-03 -1.40844

ILMN_2127328 PURA 7.56E-03 1.23212

ILMN_2128967 C11orf1 4.87E-04 -1.31286

ILMN_2129161 LRRC32 3.89E-03 -1.24594

ILMN_2129388 FAM190B 6.21E-04 1.22538

ILMN_2130525 TSPAN13 3.19E-03 -1.68508

ILMN_2132809 ARHGEF10 3.94E-03 1.359

(32)

31

ILMN_2134062 ALKBH3 2.89E-04 -1.20374

ILMN_2135984 MASTL 1.87E-03 -1.30549

ILMN_2144663 GUCY2C 4.11E-03 -1.32338

ILMN_2145396 AKR7A3 5.13E-03 1.219

ILMN_2145518 TMEM126B 5.81E-03 -1.20029

ILMN_2149053 RIF1 1.33E-04 -1.325

ILMN_2150187 KCTD18 4.37E-04 1.23315

ILMN_2150402 TMEM64 1.51E-04 -1.36767

ILMN_2151441 FAM103A1 4.61E-03 1.30688

ILMN_2154836 BTG3 4.63E-04 -1.29173

ILMN_2157441 HLA-DRA 8.42E-05 -1.32981

ILMN_2160160 SNORD36C 4.63E-04 1.2315

ILMN_2160929 FEN1 1.34E-03 -1.22277

ILMN_2163796 RABGGTB 2.53E-03 -1.31485

ILMN_2164164 AICDA 1.45E-04 1.92088

ILMN_2167416 MR1 1.11E-02 1.21014

ILMN_2173004 RAB8B 1.39E-04 -1.39298

ILMN_2173740 ASB8 1.14E-03 1.42467

ILMN_2174612 CNOT8 9.69E-03 -1.27234

ILMN_2175465 RSL24D1 1.07E-03 1.69383

ILMN_2175912 ITGB2 4.88E-03 -1.26426

ILMN_2179652 PRELID1 5.12E-03 1.32447

ILMN_2179726 C16orf93 4.93E-03 1.27305

ILMN_2184640 NOLC1 2.65E-03 -1.2178

ILMN_2186216 GOLPH4 1.56E-03 1.40379

ILMN_2188333 CD69 6.94E-03 -1.4999

ILMN_2189424 MRPL20 4.92E-03 -1.31862

ILMN_2189668 NUDT11 3.61E-04 1.4128

ILMN_2191568 TUSC4 3.20E-03 1.21857

ILMN_2193706 HRK 8.24E-03 1.27618

ILMN_2194852 FLJ46309 5.94E-04 1.25498

ILMN_2196097 PPP2CA 4.61E-03 -1.20008

ILMN_2196550 C13orf18 8.82E-03 1.27601

ILMN_2197365 RGS2 2.80E-04 -1.57905

ILMN_2201533 C17orf61 5.90E-03 1.38502

ILMN_2209180 P15RS 8.60E-05 2.07965

ILMN_2213297 C11orf54 1.43E-03 -1.2398

ILMN_2214144 TWSG1 4.72E-06 1.4424

ILMN_2214355 RAB30 2.60E-03 -1.23842

ILMN_2215631 OTUD6B 3.85E-03 1.30099

ILMN_2216157 GNA12 4.24E-03 1.26426

ILMN_2217935 RFC1 2.30E-03 -1.24731

ILMN_2218856 CCL3L1 6.86E-03 -1.34492

ILMN_2222688 TMSB4X 7.59E-03 -1.28373

ILMN_2222872 RBM18 9.74E-04 -1.23536

ILMN_2222880 SLC25A42 8.29E-03 1.20383

ILMN_2222984 RDH14 6.28E-03 -1.24968

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