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Effect of HIV antiretroviral drugs on antigen processing and epitope presentation by MHC-I to cytotoxic T cells

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HAL Id: tel-01362212

https://tel.archives-ouvertes.fr/tel-01362212

Submitted on 8 Sep 2016

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Effect of HIV antiretroviral drugs on antigen processing

and epitope presentation by MHC-I to cytotoxic T cells

Georgio Kourjian

To cite this version:

Georgio Kourjian. Effect of HIV antiretroviral drugs on antigen processing and epitope presentation by MHC-I to cytotoxic T cells. Immunology. Université de Strasbourg, 2015. English. �NNT : 2015STRAJ027�. �tel-01362212�

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Figure

FIGURE 2. HIV PIs alter peptide degradation patterns. 3ISW9 (HQAISPRTLNAW) peptide containing HLA-B57–restricted ISW9 epitope (ISPRTL- (ISPRTL-NAW) was degraded in PBMC cytosolic extracts preincubated with DMSO ( A and B ) or 10 mM ritonavir ( C ), saquina
FIGURE 4. HIV PIs variably alter the endogenous processing and presentation of HIV epitopes by infected cells to CTLs
Fig. 1. A fluorogenic assay to measure real-time CTL-mediated cell killing. A. Principle of the coupled enzymatic assay for detection of glucose 6-phosphate dehydrogenase activity
Fig. 2. Detection of HIV-infected cells by real-time killing assay. A. HLA-B57 + B cells were infected with VSV-G-pseudotyped HIV
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