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Computational studies of tau protein : implications for the pathogenesis and treatment of neurodegenerative diseases

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Academic year: 2021

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Figure

Figure  1  Primary  structure of  the  common  isoforms  of  proteins  involved  in  neurodegenerative  diseases.
Figure 2  Schematic  of a conformational  free energy  landscapes.  A)  The  conformational  free-energy  landscape of a  folded  protein  exhibits  a  deep  well-defined  minimum  corresponding  to  the native  conformation
Figure  5 RMS  fluctuations  for  100ps simulation  (100ps  equilibration,  100ps  production  dynamics  all  at 300K) of PHF6 in  different  solvent  models  using a  Berendsen  heat bath
Figure  6:  Pairwise  distance  matrices  between  minimized  structures from  the  (A)  vacuum  simulations  and (B)  explicit  solvent  simulations
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