The inflammatory preatherosclerotic remodeling induced by intermittent hypoxia is attenuated by RANTES/CCL5 inhibition.: Vascular remodeling due to intermittent hypoxia

HAL Id: inserm-00786346

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Submitted on 8 Feb 2013

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RANTES/CCL5 inhibition.

Claire Arnaud, Pauline Beguin, Sylvie Lantuejoul, Jean-Louis Pepin,

Christiane Guillermet, Graziano Pelli, Fabienne Burger, Vanessa Buatois,

Christophe Ribuot, Jean-Philippe Baguet, et al.

To cite this version:

Claire Arnaud, Pauline Beguin, Sylvie Lantuejoul, Jean-Louis Pepin, Christiane Guillermet, et al.. The inflammatory preatherosclerotic remodeling induced by intermittent hypoxia is attenuated by RANTES/CCL5 inhibition.: Vascular remodeling due to intermittent hypoxia. American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2011, 184 (6), pp.724-31. �10.1164/rccm.201012-2033OC�. �inserm-00786346�

Concanavaline-A ( g/ml) Concanavaline-A ( g/ml) Proliferation (% of unstimulated) Migrated c e ll s (% of control) Fold inducti on Fold inducti on 400 300 200 100 0 unstimulated IFNγ 5 14 MCP-1/CCL2 18S rRNA 5 14 Fold inducti on Fold inducti on Fold inducti on RANTES/CCL5 5 14 MIP-1 /CCL3 MIP-1 /CCL4 5 14 5 14

(days) (days) (days)

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2-way ANOVA, N vs IH

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