Supplementary Table 1:5yr probabilities of NRM by conditioning regimen and prognostic variable
MAC (N=781) RIC (N=1443)
N Probability%
(95% CI)
p-value N Probability (95% CI)
p-value
Disease Stage at HSCT Responding/ Stable
Relapse, Refractory, Progression Untreated
Other
150 284 302 45
30.8 (24-40) 36.7 (31-43) 33.7 (29-40) 35.8 (24-54)
0.56 27
0 52
2 54
8 10
3
31.1 (26-38) 38.4 (34-43) 34.2 (30-39) 27.1 (19-38)
0.089
Patient age (y)
<40 40-50 50-60 60-70
>70
98 218 276 179 10
20.0 (13-30) 30.6 (25-38) 36.9 (31-44) 42.7 (35-52)
NR
0.005 68 21 1 63
6 50
1 27
22.1 (14-35) 27.9 (22-35) 32.5 (29-37) 42.5 (38-47) 20.2 (9-45)
<0.001
HLA Match Matched sibling Matched unrelated Mismatched unrelated Unrelated
317 60 19 385
24.6 (20-30) 30.2 (21-45) 42.1 (24-73) 43.5 (38-50)
<0.001 55
2 10
1 41 74 9
29.6 (26-34) 35.1 (27-46) 62.2 (48-80) 36.9 (33-41)
<0.001
Karnofsky performance status (%)
100 150 27.5 (21-37) 35 30.7 (27-35)
90 80
<80 Missing
315 142 44 130
31.0 (26-37) 40.2 (33-50) 47.9 (34-66)
0.014 6
50 1 27
9 10
8 19
6
39.2 (34-46) 38.3 (30-50) 39.4 (33-47)
0.008
Co-morbidity No
Yes Missing
210 105 466
30.3 (24-38)
35.9 (31-41) 0.39 45
9 32
3 66
1
28.7 (34-38)
36.7 (33-41) 0.028
Patient / Donor CMV Match -/-
-/+
+/- +/+
Missing
204 81 156 289 51
29.8 (24-38) 38.1 (28-51) 42.0 (34-51) 31.8 (27-38)
0.11 42
9 15
8 26
4 54
6 46
32.4 (28-38) 34.3 (27-43) 37.8 (32-45) 33.7 (30-38)
0.09
Supplementary Table 2: Multivariable analysis of NRM
MAC RIC
N RR (95% CI) p-value N RR (95% CI) p-value
Patient age (y)
<40 30-50 50-60 60-70
>70
98 21 8 27
6 17
9 10
1.00 1.36 (0.8-2.2) 1.61 (0.99-2.6)
1.83 (1.1-3.1) 3.17 (1.2-8.6)
0.23 0.052 0.021 0.023
66 204 611 490 26
1.00 1.40 (0.8-2.5) 1.60 (0.96-2.8)
2.56 (1.5-4.4) 1.14 (0.4-2.9)
0.24 0.05
<0.001 0.78
HLA Match Matched Sibling Matched unrelated Mismatched unrelated Unrelated
31 7 60 19 38 5
1.00 1.24 (0.7-2.1) 1.65 (0.8-3.5) 1.79 (1.3-2.4)
0.41 0.19
<.001
525 98 39 735
1.00 1.13 (0.8-1.6) 2.26 (1.5-3.4) 1.15 (0.97-1.4)
0.21
<0.001 0.047
Karnofsky performance status (%)
100 90 80
<80 Missing
15 0 44 14 2 31
5 15
0
1.00 1.17 (0.8-1.6) 1.65 (1.1-2.4) 2.18 (1.3-3.8) 1.77 (1.1-2.8)
0.61 0.032 0.005 0.013
347 497 270 102 181
1.00 0.93 (0.7-1.2) 1.30 (0.99-1.7)
1.46 (1.0-2.1) 1.43 (1.1-1.95)
0.58 0.063 0.043 0.022
Supplementary Table 3:5yr probabilities of survival by conditioning regimen and prognostic variable
MAC (N=781) RIC (N=1443)
N Probability%
(95% CI)
p-value N Probability (95% CI)
p-value
Disease Stage at HSCT Responding/ Stable
Relapse, Refractory, Progression Untreated
Other
150 284 302 45
59.2 (51-69) 47.8 (42-55) 55.2 (49-62) 52.3 (39-70)
0.067 27
0 52
2 54
8 10
3
54.3 (48-61) 44.6 (40-50) 53.9 (50-59) 59.0 (50-70)
0.008
Patient age (y)
<40 40-50 50-60 60-70
>70
98 218 276 179 10
74.2 (66-84) 55.9 (49-64) 50.0 (44-57) 43.0 (35-52)
NR
<0.001 68 21 1 63
6 50
1 27
73.1 (63-85) 60.0 (53-68) 54.3 (50-59) 39.0 (35-44) 65.5 (48-89)
<0.001
HLA Match Matched sibling Matched unrelated Mismatched unrelated Unrelated
317 60 19 385
61.6 (56-68) 57.9 (47-72) 47.4 (30-76) 44.7 (39-51)
0.006 55
2 10
1 41 74 9
55.5 (51-60) 47.3 (38-58) 30.0 (18-49) 49.3 (45-54)
0.001
Karnofsky performance status (%)
100 90 80
<80 Missing
150 315 142 44 130
64.0 (56-73) 56.6 (51-63) 43.3 (35-53) 37.0 (25-50)
<0.001 35
6 50
1 27
9 10
8 19
6
56.0 (50-62) 56.1 (52-61) 47.0 (41-54) 35.8 (27-47)
<0.001
Patient gender Male Female
494 287
49.8 (45-55) 58.5 (53-65)
0.027 91 3 53
0
49.8 (46-54) 53.0 (49-58)
0.13
Co-morbidity No
Yes Missing
210 105 466
56.1 (49-64)
49.7 (40-62) 0.50 45
9 32
3 66
1
60.8 (55-67)
48.4 (44-54) 0.001
Patient / Donor CMV Match -/-
-/+
+/- +/+
Missing
204 81 156 289 51
59.1 (52-67) 52.4 (42-66) 46.2 (38-56) 54.4 (48-61)
0.073 42
9 15
8 26
4 54
6 46
55.3 (50-61) 51.0 (43-60) 43.7 (38-51) 52.1 (48-57)
0.009
Supplementary Table 4: Multivariable analysis of Survival
MAC RIC
N RR (95% CI) p-value N RR (95% CI) p-value
Patient age (y)
<40 40-50 50-60 60-70
>70
98 21 8 27
6 17
9 10
1.00 1.45 (0.9-2.2) 1.78 (1.2-2.7) 2.11 (1.4-3.3) 3.20 (1.2-8.4)
0.09 0.006
<0.001 0.019
66 204 611 490 26
1.00 1.35 (0.8.1-2.2)
1.60 (1.0-2.6) 2.68 (1.7-4.3) 1.31 (0.6-2.9)
0.24 0.05
<0.001 0.51
HLA Match Matched Sibling Matched unrelated Mismatched unrelated Unrelated
31 7 60 19 38 5
1.00 1.12 (0.7-1.7) 1.39( 0.7-2.6) 1.43 (1.1-1.8)
0.59 0.30 0.005
525 98 39 735
1.00 1.13 (0.8-1.6) 2.26 (1.5-3.4) 1.15 (0.97-1.4)
0.46
<0.001 0.13
Karnofsky performance status (%)
100 90 80
<80 Missing
15 0 44 14 2 31
5 15
0
1.00 1.17 (0.8-1.6) 1.65 (1.2-2.4) 2.18 (1.4-3.5) 1.77 (1.2-2.6)
0.37 0.007 0.001 0.003
347 497 270 102 181
1.00 1.01 (0.8-1.3) 1.30 (1.02-1.6)
1.86 (1.4-2.5) 1.54 (1.2-2.1)
0.96 0.032
<0.001 0.002
Patient gender
Female 28 1.0
Male 7 19
4
1.30 (1.03-1.6) 0.039
Patient / Donor CMV Match -/- -/+
+/- +/+
429 158 264 546
1.00 1.28 (0.97-1.7)
1.38 (1.1-1.7) 1.10 (0.95-1.4)
0.079 0.005 0.14