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DTI Fiber tracking Analysis of the visual input to the pallidum in humans: preliminary results

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HAL Id: hal-01871284

https://hal.uca.fr/hal-01871284

Submitted on 8 Nov 2018

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DTI Fiber tracking Analysis of the visual input to the

pallidum in humans: preliminary results

Hachemi Nezzar, Laurent Sakka, Jerome Coste, Jean Gabrillargues, Frédéric

Chiambaretta, Jean-Jacques Lemaire

To cite this version:

Hachemi Nezzar, Laurent Sakka, Jerome Coste, Jean Gabrillargues, Frédéric Chiambaretta, et al..

DTI Fiber tracking Analysis of the visual input to the pallidum in humans: preliminary results.

Research in Vision and Ophthalmology ARVO Annual Meeting, ARVO, May 2013, Seattle, United

States. pp.5542. �hal-01871284�

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Nezzar A. et al. - ARVO – Seattle, Washington (2013)

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DTI Fiber tracking Analysis of the visual input to the pallidum in

humans: preliminary results

Hachemi Nezzar

Dept of Ophthalmology, CHU Clermont Ferrand, Clermont-Ferrand, France IGCNC EA 3295, Université d'Auvergne, Clermont Ferrand, France

Laurent Sakka

IGCNC EA 3295, Université d'Auvergne, Clermont Ferrand, France Dept of Neurosurgery, CHU Clermont Ferrand, Clermont Ferrand, France

Jerome Coste

IGCNC EA 3295, Université d'Auvergne, Clermont Ferrand, France Dept of Neurosurgery, CHU Clermont Ferrand, Clermont Ferrand, France

Jean Gabrillargues

IGCNC EA 3295, Université d'Auvergne, Clermont Ferrand, France

Dept of Radiology, neuroradiology, CHU Clermont Ferrand, Clermont Ferrand, France

Frederic Chiambaretta

Dept of Ophthalmology, CHU Clermont Ferrand, Clermont-Ferrand, France

Jean Jaques Lemaire

IGCNC EA 3295, Université d'Auvergne, Clermont Ferrand, France Dept of Neurosurgery, CHU Clermont Ferrand, Clermont Ferrand, France

Purpose

Deep brain stimulation (DBS) of the Globus Pallidus interna (GPi) and the subthalamic nucleus (STN) is a current surgical technique for the treatment of movement disorders such as those in Parkinson’s disease (PD). During GPi DBS eye movement impairments (saccade movement disturbance) were reported. The basal ganglia (BG) are well known to influence eye movement through action of the caudate nucleus, the STN and the subtantia nigra reticulata, but little is known about the GPi.GPi is the main output of the BG that has been extensively explored for movement and behavioral controls. However, recent experimental studies in monkeys have shown the existence of GPi neurons modulating their activity in relation to saccade, and smooth pursuit, suggesting that GPi might be involved in saccade and pursuit control loops. This hypothesis could be consistent with clinical observations. We hypothesized that direct visual input into the GPi could be detected using diffusion tensor imaging (DTI) and fiber tracking (FT); these fibers could belong to the supraoptic commissural system (Ganser, Meynert, Gudden).

Methods

Ten patients (5 PD; 5 essential tremor) who undergone neurosurgical stereotaxic procedure for movement disorders were retrospectively analyzed. We explored DTI acquired routinely for the surgical planning. DTI fiber tracking (FT; voxel = 0.52 × 0.62 × 2 mm3, fiber length ≥ 15 mm, FA threshold ≥ 0.22; Iplan 3 BrainLab) was carried on within the right and left hemispheres. FT was performed between the optical tract and the GPi. The two region-of-interests were outlined on the MRI anatomical images used for surgical planning.

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Nezzar A. et al. - ARVO – Seattle, Washington (2013)

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Results

In all the 20 regions (10 patients right and left hemispheres) we have found a fascicle connecting the optical tract and the GPi.In this study, using DTI FT, we identified direct optic tract connection to the GPi; this pathway could be involved in saccade, eye pursuit control.

Conclusions

Further works are mandatory to evaluate this hypothesis, using both functional and structural approaches, enabling the description of an optical-basal ganglia connectome, which could be useful to interpret clinical observations.

A: Coronal plane, MRI 1.5 T WAIR sequence. Fiber bundle is obtained from two ROIs: optic tract (yellow) and GPi (blue) B: DTI of the left GPi (blue) and and the left optic tract (yellow).Fiber bundle (red) can be seen, connecting them.

Keywords

Anatomy, eye movements: saccades and pursuits, imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)

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