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Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway

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Academic year: 2021

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Fig. 2 Expression of PTX3 in malignant melanoma. a Box and Whisker plots (10th to 90th percentile) show PTX3 mRNA expression in metastatic vs
Fig. 3 Increased PTX3 expression in BRAF inhibitor mesenchymal resistant melanoma. a Immunoblot analyses of PTX3 expression in isogenic pairs of sensitive (M229S, M238S) and vemurafenib-resistant melanoma cells (M229R, M238R)
Fig. 4 Melanoma-derived PTX3 promotes tumor cell migration. a A375, 1205Lu, M229R, M238R, and patient-derived (Pt1) melanoma cells were transfected with siCTRL or two different siPTX3
Fig. 5 PTX3 increases melanoma invasiveness in vitro. a Transwell invasion assays were performed on siCTRL and siPTX3 transfected cells (1205Lu, A375, M229R) obtained from transfections performed for migration assays (Fig
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