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Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

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Academic year: 2021

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Figure

Fig. 1 MS-induced depressive-like symptoms and hyperexcitability. a MS protocol (all schematics are original drawing made by authors)
Fig. 2 MS drives GABA B -GIRK plasticity in LHb. a Sample traces, bar graph and scatter plots depicting CGP54626-sensitive I-Baclofen (I-Baclofen Ctrl vs.
Fig. 3 MS-induced LHb neurons hyperexcitability requires reduced GABA B -GIRK signaling
Fig. 4 Chemogenetic and DBS approaches reduce LHb activity and ameliorate MS-dependent depressive-like symptoms

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