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Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease.

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Academic year: 2021

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Figure 1 Schematic representation of the sphingolipid rheostat in AD context. Ceramide can be generated de novo or by hydrolysis of sphingomyelin by sphingomyelinase
Table 2 Characteristics of patients included in the immunoblot study
Figure 3 Correlation between neurons with strong expression of SphK1 and Aβ deposits. (a) Packing density of SphK1++ neurons and density of Aβ deposits are not correlated in frontal cortex
Figure 4 Correlation between neurons with strong expression of SPL and Aβ deposits. (a) Packing density of SPL++ neurons and density of Aβ deposits are not correlated in frontal cortex

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