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Optocontrol of glutamate receptor activity by single side-chain photoisomerization

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Academic year: 2021

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Figure

Figure 1. General principle for genetic encoding photoswitchable UAAs into membrane receptors
Table 1. Screening for expression and photosensitivity of NMDAR Amber mutants. Overview of all Amber positions screened for PSAA insertion within the NTD, ABD, and TMD
Figure 2. Reversible photomodulation of NMDARs with PSAA at the GluN1-P532 site. (a) Structure of a heteromeric GluN1/GluN2B receptor (left panel)
Figure 3. Photomodulation properties of GluN1-P532PSAA/GluN2A receptors. (a) Kinetics of photoinhibition and its recovery
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