• Aucun résultat trouvé

Analyzing the sequence-structure relationship of a library of local structural prototypes.: Sequence-Structure Relationship

N/A
N/A
Info
Télécharger
Protected

Academic year: 2021

Partager "Analyzing the sequence-structure relationship of a library of local structural prototypes.: Sequence-Structure Relationship"

Copied!
32
0
0

Chargement.... (Voir le texte intégral maintenant)

Texte intégral

(1)Analyzing the sequence-structure relationship of a library of local structural prototypes. Cristina Benros, Alexandre de Brevern, Serge Hazout. To cite this version: Cristina Benros, Alexandre de Brevern, Serge Hazout. Analyzing the sequence-structure relationship of a library of local structural prototypes.: Sequence-Structure Relationship. Journal of Theoretical Biology, Elsevier, 2009, 256 (2), pp.215-26. �10.1016/j.jtbi.2008.08.032�. �inserm-00318954�. HAL Id: inserm-00318954 https://www.hal.inserm.fr/inserm-00318954 Submitted on 30 Aug 2012. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

(2)  

(3)  "!. $&%('*),+.- / %(0213(4657498;:(4<%(=>4@?5A1BC:7=D1

(4) :7B>4FEG4>) 'H1/JI.%7KL3(/MNI*OP' Q. /JR7B>'SBD+TIUO Q. I*=>'*)75A1B<:(=D1:(B>'*).VWBCIX1I 1Y+ZM74>K\[. ]*^_`a_cbedAfhgib\^jk`mlonprqsgYtLdYbLu^g7vxwyu\gAf.^gizeg{^b@l| }|"~d€beu‚Lg€^ƒgA„rdY yj

(5) †

(6) a‡l| ˆ. ‰Š>‹ŒŽ‘ ’Y‘9“HŽ”•Ž–Y—s”Y˜o™›šœŽ‹Œy‘ žXŸ –Y”•™.Ž‹Œ ‘ ‘œ¡¢”i£Ÿ¤Œ£¥š Ž˜‘ ¦cŠD“HžH¡¢§¨ ©ª(« ŠD¬>¡®­¯¡°¬H± «²{³´ ¨€­U–YŽµ‘J˜·¶Ž¸œŸ9¹.‘ –YŽ¶\¹.Ž¥’Y‘J˜”œ

(7) ± ºešJ˜Ž¶ ² ¨¤ š¶»‘ ²\¼Y¼½ ¨ ³ ¨YY£š ¤ ‘C¾Œ\¶,¶Ž¥‘Œy¨ ²•¿³¿¼ ºešJ˜Ž¶»¨€À˜»šJ–¤ ‘ Á © –¶ÂœsŽ"œŒYœ ª š·œsŽ”Y–šÃ£’Y‘ ÄL˜šJ–¶—cŒÅ¶Ž”Y– « š –{Æ{ŒyŽÇ–‘ ¦ ©ª Ä « §¨ ´ ¨Y˜ÂŒy‘9ÈX£¥‘Jɏš –Y’{˜‘ Ê>šJˏš –€‘ą̃ ²•¿m²Y½YÍ ºešJ˜Ž¶D¤ ‘’Y‘É ¼ ¿ ¨€ÀŘšJ–€¤ ‘. Î Ê>”{˜˜‘¶”i–€’iŽ–{ƛšŒYœsπ”i˜Ð ¡‚š Ž£Ž–YÆ&š ’Y’{˜‘¶,¶Ð(ÈX£¥‘Éyš –€’{˜‘Ñž.Ò(’Y‘F“C˜»‘µi‘J˜–Y¨(Š‹ŒŽ‘Ó’Y‘Ó“HŽ”•Ž–Y—s”Y˜o™›šœŽ‹Œy‘ÑžXŸ –Y”•™.Ž¥‹Œy‘6‘œ ¡‚”Y£¥Ÿ ¤Œy£¥šÃŽ˜·‘Ô¦cŠÕ“HžC¡P§¨ ©ª7« ŠÕ¬>¡ ­¯¡°¬ ± «•²{³´ ¨¯­U–YŽµy‘J˜·¶Ž"œŸx¹Ö‘ –YŽ¶×¹.Ž¥’Y‘J˜”œ;±ØºešJ˜Ž¥¶ ² ¨ © –¶ÂœsŽ¸œŒYœ  š s œ  Ž Y ” Y –. š  £ Y ’. ‘ L Ä  ˜ J š  –  ¶ c —  Œ  ¶ Ì Ž • ” –. š { – { Æ y Œ Ç Ž  –  ‘ ¨ ª « ´ ¨{˜ÂŒy‘CÈX£‘Jɏš –€’{˜·‘ Ê>šËiš –‘ą̃ ²•¿m²Y½YÍ ºešJ˜Ž¶D¤ ‘’Y‘É ¼ ¿ ¨€À˜»šJ–Y¤ ‘ Š±Â™.š Ž£Ð š £¥‘Jɏš –Y’{˜‘mÒ"’Y‘ËY˜‘Jµ‘˜o–Ùڌy–YŽµy±ÂšJ˜Ž¶±’YŽ’‘J˜”œ,Òۗ˜ ÄD‘ãcÐÜ ½Y½ ¦ ¼ §LÝYÝ*Ý Í.½YÞ*ÞYÞ ÀŚJÉÅÐÜ ½Y½ ¦ ¼ §LÝ ²S½ Ý ² Ý ½\¼. ¬>Œ–Y–YŽ–YÆ֜sŽ¸œ£‘ Ð « ‘ ‹Œy‘ –Y¤ ‘ ± « œs˜sŒy¤‡œŒ˜‘9¬H‘J£ÌšœŽÌ”i–¶ÏYŽ. ‘ à{á֔i˜»’•¶ ÐڐY˜”œ‘ŽÇ–⣔¤ š £ã¶Âœs˜ÂŒy¤·œŒ˜‘ ¨ä¶œs˜ÂŒy¤·œŒ˜šJ£‚š £•Ï€šËi‘œ¨ä¶Âœs˜ÂŒy¤·œŒ˜šJ£‚™.”{œŽ—F£Žˀ˜šJ˜à⒏‘¶Žƕ–€¨ ß J ¶‘‹Œy‘Ö€¤ ‘ ±o¶sœs˜ÂŒy¤œŒ˜‘<¤J”Y˜˜‘£šœŽ”i–€¨•š ™.Ž–Y”›š ¤ Ž’.‘ ‹ŒŽµyš £‘–Y¤‘ ¤ £š{¶·¶‘{¶‡Ò. å ’Y‘ ¤ ‘š¶‘ ’. #.

(8)  

(9)  "!.  

(10)  . ‘אY˜‘¶,‘ –œÖšØœsπ”i˜”€ŒÆYςš–Yš £Çày¶Žc¶›”— œsπ‘. ˜»‘㥚œsŽÌ”i–Pˏ‘œá֑ ‘ –‚š ™.ŽÇ–€”äš ¤ Ž¥’. œsÏ{˜»‘ ‘ ±’{Ž™›‘ –¶Ž”•–Yš £ ¶Âœs˜sŒy¤‡œŒ˜‘7ŽÇ–rY˜”{œ‘JŽ–•¶‡ÒLÈG£Žˏ˜šJ˜à‚”Y—X”{µ‘J˜£šJYŽ–YÆ á֚¶CË{ŒyŽ£¸œ Œ¶Ž–YÆ. . ÄLÏY‘ ¯ºÅ¡. š –ZŒ–¶ÂŒy‘J˜ÂµŽ¶,‘ ’פ £ŒÅ¶Âœ‘J˜Ž–mÆ. ¶‘‹Œy‘Ö€¤ ‘rš –Y’. £”¤ š£. £Ì”•¤ š £ ¶Âœs˜sŒy¤œŒY˜š£ Y˜”œs”œàm‘{¶. *à{ˀ˜oŽ¥’(ºÅ˜”œ‘JŽ–(¡x”•’Y‘ £ ¦¯º¡P§‡Ò. šYY˜”Yš ¤JÏr¤šÃ£¥£¥‘ ’. ¤ šJ˜˜Ž¥‘¶h”€ŒYœÖšÚ™XŒ£"œŽ£¥‘x¶Âœs˜sŒy¤œŒ˜šJ£<š £ŽƏ–Y™A‘ –œ.”Y—.£”•¤šÃ£ —s”£’•¶h—˜”•™Nšr–Y”Y–Y±Â˜»‘ ’Œ–Y’š –œ. . . Y˜”œ‘JŽ–׶sœs˜ÂŒy¤œŒY˜»‘S’Yš·œšËišÃ– ב –€¤ ”•’Y‘’(Ž–œ”ךA¶œs˜ÂŒy¤·œŒY˜šÃ£Åš £•Ï€šJˏ‘œ¤ ”Y™*” ¶»‘ ’7”i— ¼´ ºÅ˜”œ‘ Ž–A“ £Ì”•¤ ¶. . ¦cº“X¶§ÒYÀŔY£Ç£Ì”€á.Ž–YÆ7Y˜‘µŽ”{Œ¶>˜‘¶»‘šJ˜¤ Ï(—s”¤Œ¶Ž–{Æ;”Y–AœÏY‘ Xº¡ Ž–Øœsπ‘A£”¤ š £ ¶Âœs˜ÂŒy¤·œŒ˜‘*Y˜”œc”œàm‘{ÒÄLÏYŽ¶ ™›‘œsÏY”’Y”i£Ì”iÆ{à. ֑J–Y¤‘ ¨ Xº

(11) ¡. Y˜”œs”¤ ”Y£¨ á֑*ÏYšJµ‘.¤ ”Y–•¶Ž¥’Y‘J˜‘’ØƏšJ¶. š £Ç£Ì”€á6œsÏY‘.ÏYšJµy‘ÖµišJ˜Ž¥šˏ£¥‘.£‘ –mÆ{œsÏ(—s˜šJƏ™›‘Öœ¶Ò. . ¼³Þ £”¤ š £Õ¶Âœs˜sŒy¤œŒY˜‘*Y˜”œs”œàm‘{¶ á.‘˜‘.”€ËmœšÃŽ–‘ ’Ò ³¿. ”i—LœsÏY‘*Y˜”œ‘JŽ–7—˜»šJƕ™›‘ –œ¶<£¥‘ šJ˜–œÕˏà. ÏYš ’*ƏšJ¶‡Ò. ÈX–AŽ–{µy‘{¶ÂœŽƏšœŽ”Y–›”i—œŽƏύœÅœŒ˜–•¶>¶sŒÆYƏ‘¶Âœ‘ ’*œsÏYšœÅœsÏY‘JàhšJ˜‘¯™ÖšÃŽ–£Çàh’Y‘J˜Žµy‘ ’A—s˜”i™. Xº

(12) ¡ ¤ ”Y–Y—s”i˜™AšœsŽ”i–š £;¤ £š{¶,¶‘{¶Pá.š¶Pœš ¤ •£‘’. á.Ž"œsÏӐY˜‘ ¤ Ž¶‘F£”¤ šœsŽÌ”i–¶‚Ž–ÑœsÏY‘. ÒAÄLÏY‘ ËYà. š ™.ŽÇ–y”. š¤JŽ’. œsÏ{˜‘ ‘Cº“F¶,‘J˜Ž‘{¶. Ž–—s”i˜™›šœsŽ”Y–6¤ ”Y–œ‘ –œ°”i—לsπ‘. á.ÏY”•£¥‘.  . ™*Œy£"œŽÌµyš ˜Žšœ‘F™.‘œsπ”•’•¶»¨ YÒ DÒ¸¨(¤šJ–Y”Y–YŽ¥¤ š £×¤ ”Y˜˜‘ £šœŽ”Y–. šJ–€šÃ£à¶,Ž¶Ò © œX”YŽÇ–œ¶.”{Œ{œ<œsÏY‘(Y˜‘¶‘ –Y¤‘×”•—*¶,‘Jµi‘Ö¢š ™AŽ–€”. š¤ÃŽ¥’P‘ ‹ŒyŽµyš £‘ –€¤‘;¤Ã£¥š{¶·¶»‘{¶A¶ÏY”{á.Ž–{ÆÔÏYŽÇƏÏ. . "!. Y˜”Y‘J–•¶Ž¸œŽ‘{¶>—s”Y˜ Y˜‘J—s‘˜‘ –œŽš £\£”¤ š £Õ¶sœs˜ÂŒy¤‡œŒ˜»‘¶Ò © –.œsÏY‘S¶»šÃ™›‘ á֚Jà¨’Y‘ —ÂŽ–Ž"œŽ”•–Z”— ¤ ”Y–œs˜š¶sœD—sš ¤œ”Y˜·¶ ˏš{¶»‘ ’. ”Y–. ¶‘ ‹Œy‘ –Y¤‘ ±¶Âœs˜ÂŒy¤·œŒ˜‘®Y˜”Y‘J˜œsŽ‘¶6Œ–€’Y‘J˜£ŽÇ–‘Gœsπ‘. ¶‘¤ Ž—Ž¥¤ Ž"œÂà. ”—Ѥ‘J˜ÂœšŽÇ–. ¶Âœs˜sŒy¤œŒY˜š £. # . Y˜”œc”œà{‘¶¨ YÒ DÒ¸¨yœsπ‘*’Y‘J‘ –Y’Y‘ –€¤ ‘.”i—@ž¯£Çàؔi˜@ÈS¶–€±Â˜Ž¤ ÏSœŒ˜–¶ œ”(š¯£Ž¥™AŽ"œ‘ ’7–Œy™ÖËy‘˜>”i—Lº“X¶¨”i˜»¨iœsÏY‘ ”YYY”¶Ž"œŽ”Y– šJ˜‘P¶”. Ëi‘œá֑ ‘J–(ºÅ˜”±c˜Ž¤ Ïr¤ ”•Ž£¶Cœ”Øœsπ” ¶»‘A‘J–m˜oŽ¥¤ Ϗ‘ ’׎–. %$. Œ¶‘—Œ£Cœ”äš–Yš £Çà ‘. « ‘J˜¨LÄLÏ{˜¨LÈ*¶–rš –Y’rž¯£¸ŒÅÒÄÕÏY‘{¶‘.˜‘¶sŒ£"œ,¶. '&F¶sœs˜ÂŒy¤‡œŒ˜‘Ú˜»‘ã̚œŽÌ”i–¶ÏYŽÇ¶»¨HËmŒYœ›¤”€Œ£’Ԛ㶻”ÔËi‘. œsπ‘x¶‘‹Œy‘Ö€¤‘. Ž™.Y˜”{µ‘ —˜šJƏ™›‘ –œ±cËiš¶‘ ’.™›‘œsÏY”’*—s”i˜Lm˜”œ‘JŽ–A¶sœs˜ÂŒy¤œ¥Œ˜‘CY˜‘ ’{Ž¤œŽ”Y–.—˜”•™Ñ¶»‘ ‹Œy‘ –Y¤ ‘{Ò. Œ¶,‘ ’Pœs”.

(13)  

(14)  "!. . 

(15)

(16)   . ß –Y”{á.£‘’{Ə‘S”Y—DY˜”œ‘JŽ–AœsÏ{˜‘‘ ±’YŽÇ™›‘ –¶Ž”•–€š £\¦ ½ ¹*§C¶sœs˜ÂŒy¤œŒ˜‘¶>”Y—D¤ ”i–œs˜ŽË{ŒYœ‘¶Dœ”hŒ–€’Y‘J˜·¶sœšJ–Y’Sœsπ‘ÃŽ˜. . ˏŽ”•£Ì”iƏŽ¥¤ š £ —Œ–¤œsŽÌ”i–¶›¦c“Hš ‘˜Aš –€’. « š £Ž¨ ³ÞYÞ\¼ §ÒkºÅ˜‘’YŽ¤œŽÇ–mÆ. ¶‘‹Œy‘Ö€¤ ‘{¶°¤ ”Y–¶ÂœsŽ"œŒYœ‘¶°šW™›š»”i˜P¶¤ Ž¥‘ –œŽ—ÂŽ¥¤ã¤ πšÃ£¥£¥‘ÖYƏ‘. Y˜»”œ‘JŽ–. ¶sœs˜ÂŒy¤‡œŒ˜»‘¶.—˜”•™âš ™.ŽÇ–€”䚤 Ž’. Ëi”€œsÏU±Â˜šJà. á.π‘ –. ¤˜»ày¶Âœš ££”YÆY˜šJÏ{àӚ֏’. . –Œy¤ £¥‘ šJ˜<™›šJƕ–‘œsŽ¤*˜‘¶”Y–Yš –Y¤‘.š –Yš £Çày¶Žc¶HšJ˜‘.’YŽ—s—Ž¥¤JŒ£"œDœs”ZŒ–Y’Y‘J˜Âœš ‘{Òiº˜»‘ ’{Ž¥¤œsŽ”Y–×™›‘œsÏY”’•¶<šJ˜‘¯Ëyš¶»‘’ ”Y–. œsÏY‘Ú—sš¤œ¯œsπšœ œsÏY‘rš ™AŽ–€”äš ¤ Ž¥’. ¶‘ ‹Œy‘ –€¤ ‘. ”Y—*šr•˜»”œ‘JŽ–䶐‘¤ ŽÇ—Ž‘{¶›Ž"œ¶ ½ ¹. ¶Âœs˜ÂŒy¤·œŒ˜‘{ÒL¹*Ž—s—‘˜‘ –œ. šJYY˜”š ¤J𑍶@šJ˜‘X¤Œ˜˜‘–œs£à.Œ¶,‘ ’Öœc”A{˜‘ ’{Ž¥¤œeÆY£”{ˏš £Y˜”œ‘JŽ–Z¶Âœs˜sŒy¤œŒY˜‘¶ÐY¦ÂŽ§@¤ ”Y™*šJ˜šœŽµ‘¯™Ö”•’Y‘ £Ž–YÆZŽ¶ ¤ šJ˜˜oŽÌ‘ ’ã”{Œ{œ›á*π‘J–äœsÏY‘. Y–Y”{áU–. ½ ¹. œšJ˜Ə‘·œ×¶‘‹Œy‘J–Y¤ ‘ä¶ÏYš˜‘{¶×šPƏ”Y”’. ¶‘‹Œy‘J–Y¤ ‘䶎™›Ž£š˜oŽ¸œÂàWá.Ž"œÏWY˜”œ‘JŽ–•¶;”•—. ¶Âœs˜ÂŒy¤œŒ˜»‘¶Z¦ « š£ÇŽXš –€’Ô“H£Œ–€’Y‘㥣¥¨ ¼ÍYÍY½ §¨ ¦ŽÇŽ§AœsÏ{˜‘ š’iŽ–YÆWšJYY˜»”•š ¤Ï䎶AŒ\¶»‘ ’xá.π‘ –. œ‘J™*£¥šœ‘׶œs˜ÂŒy¤·œŒ˜‘ZŽc¶UÏYšJ˜»’. œ”. —sŽÇ–€’. ’Œy‘Øœc”Pš(£”{á. ¶‘ ‹Œy‘–¤ ‘. œsÏY‘. ¶Ž¥™AŽ¥£š˜oŽ¸œÂàyÒ © œU¶‘ š˜¤JϏ‘¶U—s”i˜ œsÏY‘ØËi‘¶Âœ. . ¤ ”Y™*šœŽˏŽ£Ž¸œÂàZËi‘œá.‘‘ÖAœsπ‘¯œšJ˜Ə‘·œC¶»‘ ‹Œy‘J–Y¤‘Sš –€’ –”€áU–ZY˜”œ‘JŽ–(—s”•£¥’•¶<¦ Œ. ‘œ>š£Ò¸¨ ³ÞYÞ\¼ §¨¦ÂŽŽŽ§

(17) .  ™Ö‘œsÏY”’•¶ š˜‘Zšœœ‘™*{œ‘ ’×—s”i˜<Y˜”œ‘JŽ–¶>á.Ž"œÏY”{ŒYœ>‘ –Y”{ŒÆYÏ ¶»‘ ‹Œy‘ –Y¤ ‘(¶Ž¥™AŽ£¥šJ˜Ž"œsà7œ”Úš–{àאY˜”{œ‘JŽ– áUÏY”¶‘¯¶Âœs˜sŒy¤‡œŒ˜‘CŽ¥¶DšJµš Ž£¥šJˏ£¥‘9á*ÏYŽ¥£‘ ÄD”. ¤JŽ˜»¤Œ™*µy‘ –œrœsπ‘. ¤ ”™*•£¥‘JÉ. . . "!# ™.‘œsπ”•’•¶k¤ ”i™*ˏŽ–‘9œsÏY‘ ™ š ££y¦c“H”Y–{–‘ šŒh‘œešJ£ Ò"¨ ³ÞYÞ{³ §Ò. Y˜”{ˏ£‘ ™Z¶Ô”•—. Ə£”iËyš £7Y˜”{œ‘JŽ–. ¶sœs˜ÂŒy¤œŒ˜‘FY˜‘ ’{ŽÌ¤œŽÌ”i–€¨Ú¶‘Jµ‘˜š£. ˜‘¶»‘ šJ˜¤ ÏZÆY˜”{Œ¶>ÏYšµ‘S—s”¤Œ¶»‘ ’(”Y–7£”•¤šÃ£L¶sœs˜ÂŒy¤œŒY˜»‘֐m˜‘ ’YŽ¤œŽ”Y–ÒÄL”AœsÏYŽ¶<‘ –Y’Y¨œsÏY‘JàZπšJµy‘S’Y‘µy‘ã̔i‘ ’. . . —˜šJƏ™›‘ –œ±cËiš€¶»‘ ’.šJYY˜”š ¤J𑀶k¦c“Cày¶Âœs˜”Y——Ś –Y’*“Hš ‘J˜¨ ¼ÍYÍ%$"& ֚{¶‘ £y‘œešÃ£ "Ò ¨  ³ ÞYÞY½ §ÒmÄk𑍶‘ šYY˜”•š¤JÏY‘{¶ ˜‘ £ఔY–(œsÏY‘(Ï{à€”€œs𑍶Ž¶ œsÏYšœ9œsπ‘AY˜”œ‘JŽ–r—s”•£¥’iŽ–YÆ°¤ š –×ˏ‘Z˜‘JY˜‘¶‘ –œ‘ ’rš¶UšZÏYŽ¥‘J˜šJ˜¤ ÏYŽ¥¤ š £DY˜”•¤‘¶·¶»¨ áUÏYŽ¤ Ï׎–Ž"œŽšœ‘¶ £”¤ š ££Çà. ". ¦('@‘{¶ rš –Y’Z¬ ”¶‘¨ ¼Í%$¼ §ÒÄLÏ{Ž¶ ÏYŽ¥‘J˜š˜¤ ÏYŽ¤šÃ£D¤”i–€¤ ‘J{œ<Ž™S£Ž¥‘¶>œsÏYšœ>Y˜”œ‘Ž–. £”¤ š £C¶Âœs˜sŒy¤‡œŒ˜š£ÕŽ–Y—s”Y˜o™›šœŽ”Y–rŽc¶X£¥šJ˜Ə‘ £à°¤ ”Y–œš Ž–Y‘ ’rŽ–r£”¤ š £ š ™AŽ–€”. š ¤ Ž¥’x¶»‘ ‹Œy‘ –Y¤ ‘{¶¨DŽÇ–€’Y‘Jy‘Ö€’Y‘ –œ. ”Y–S£Ì”i–mƏ±Â˜š –{Ə‘ Ž–œ‘J˜š¤œŽÌ”i–¶‡Ò{ÄLÏY‘ –Y¨{œsÏY‘CƏ£”iËiš £\¶Âœs˜ÂŒy¤œŒ˜‘ ¤ š –*ˏ‘X™.”•’Y‘ £¥‘ ’*ËYàZ¤”i™*ˏŽ–šœŽ”i–›”Y—L£”¤ š£ —˜šJƏ™›‘ –œ¶\á.Ž¸œsÏ.’iŽ——‘J˜‘ –œ\˜»‘J—ÂŽ–‘ ™›‘ –œ¶D¦ ©  – ˏš˜D‘œešJ£Ò¸¨ ³ÞYÞY½ §‡Ò. . Ê>£š{¶·¶Ž¥¤š £¯¶‘¤ ”i–€’YšJ˜àW¶Âœs˜ÂŒy¤œŒY˜‘r’Y‘¶»¤J˜Ž{œŽÌ”i–‚£‘šJµ‘¶›Ý ¿. . ”Y—¯Y˜”œ‘ŽÇ–W¶Âœs˜sŒy¤‡œŒ˜‘×–€”œ.’Y‘¶»¤J˜Žˏ‘’Y¨.  Ò YÒ¸¨*¤”YŽÇ£U˜‘JƏŽ”•–•¶‡Ò © – šÃ– šœœ‘J™*{œ›œs”F’Y‘¶»¤J˜Žˏ‘ œsÏY‘䣔¤ š £A¶Âœs˜ÂŒy¤œŒ˜šJ£U¤ÃπšJ˜š ¤œ‘J˜Ž¶ÂœŽ¤{¶×Ž– š ™.”Y˜‘ š ¤ ¤Œ˜šœ‘FšJ–€’. . ¤”•™*Y˜‘ ÏY‘ –¶ŽÌµy‘ãá֚à€¨(™›š –Yà6˜‘¶»‘ šJ˜,¤JÏÑÆY˜”{Œ¶PϏšJµ‘F’Y‘{¶ŽƏ–‘ ’6£”•¤šÃ£r¶Âœs˜sŒy¤œŒ˜šJ£. š £ÏYšJˏ‘œ¶»¨ YÒ DÒ¸¨¦ « šJ–€’Y‘J˜ ‘œDš £Ò¸¨ ³ÞYÞY´)& ­.–{Æy‘J˜@‘œDš £Ò¸¨ ¼Í%$mÍ §ÒYÄLÏY‘Jàh¤ ”Y˜˜‘¶”i–€’Öœc”(¶‘œ¶@”Y— ¶Âœs˜ÂŒy¤·œŒ˜šJ£.

(18)  

(19)  "! Y˜”œc”œà{‘¶DšJˏ£‘9œc”AšJYY˜”{ÉYŽ™›šœ‘CY˜”œ‘JŽ– ½ ¹Ó¶Âœs˜ÂŒy¤·œŒY˜‘¶D¦X——s™›šÃ–Y–Ö‘œešJ£Ò¸¨ ³ÞYÞY² §‡Ò. . ‘*ÏYšJµ‘U’Y‘µi‘ £”i‘’ZšS¶ÂŒy¤ Ï(¶sœs˜ÂŒy¤·œŒ˜šJ£š £•Ï€šJˏ‘œk¦’Y‘ “<˜‘µi‘J˜–Y¨ ³ÞYޕ¿& ’Y‘ “<˜‘Jµ‘˜o–h‘œDš £Ò¸¨ ³ÞYÞYÞ §. Ž"œD˜‘’Œy¤ ‘¶Õœsπ‘¯Y˜”{œ‘JŽ– ½ ¹. ¤ ”•™*£¥‘JɏŽ"œÂà7Ž–œ”(”Y–Y‘ ±’{ŽÇ™h‘J–¶Ž”•–€š £k¶sœs˜Ž–{Æ7”•—D¤ πšJ˜š ¤œ‘˜·¶Ò{“Hš¶‘’Z”i–.œsÏYŽÂ¶. ’Y‘¶»¤J˜Ž{œŽÌ”i–€¨ÖœsÏY‘W£”¤ š £×¶Âœs˜ÂŒy¤·œŒ˜‘W’Y‘¶¤˜oŽ{œŽ”Y–•¶×á֚{¶P‘É{œ‘J–€’•‘ ’㜝”. *àmËY˜Ž¥’. Œ–•¶sŒ‘˜ÂµŽ¶,‘ ’Ѥ £Œ¶Âœ‘J˜Ž–{Æ6™›‘œsÏY”’Ѥ š£Ç£¥‘’. ֚$”{Œ{œ¨. &. ›š$”{ŒYœs¨. ³ÞYÞ\¼& ’Y‘x“<˜‘Jµ‘J˜–Fš –€’. £”Y–{Ə‘˜. —˜šJƏ™›‘ –œ¶¨*Œ¶Ž–YÆњ –.  . º\˜”œ‘JŽ–F¡‚”’Y‘ã P¦ ¯º¡‚¨Z¦’Y‘. Xº\¡. ³ÞYÞY½ §§,Ò ÄLÏY‘. œ”i€”i£”YÆ{à. “<˜‘µi‘J˜–Ӛ֏’. Ž¶ršW–Y‘Œ˜š £›–Y‘œá֔i˜. . ˜‘JY˜»‘¶‘J–œ‘ ’(ËYచA˜Ž–{Æ°”i—<–Y‘Œ˜»”i–¶ÒŠ>š ¤ Ïז€‘Œ˜”Y–r¤ ”Y˜˜‘¶”i–€’•¶Cœs”°šA¤ ”Y–{—s”Y˜™.šœŽ”Y–Yš £ ¤ £¥š¶¶X”Y— œsÏY‘ £Žˀ˜·š˜»à7ÆY˜»”€ŒŽ–{Æ. . ¶sœs˜ÂŒy¤œŒY˜»šJ££ÇàP¶Ž™AŽ¥£¥šJ˜ —˜,šJƕ™›‘ –œ¶H’Y‘J—Ž–‘ ’(ËYà. ”€Œ˜X¶œs˜ÂŒy¤‡œŒ˜»šJ£Lš £•Ï€šJˏ‘œ,ÒÄLÏY‘ ¯º¡. Y˜”¤ ‘ ’Œ˜‘9ËmŒŽ£¥’•¶ ¶sœs˜ÂŒy¤œŒ˜šJ££à›’Y‘J‘ –Y’Y‘ –œe¤ ”Y–•¶»‘ ¤ŒYœŽµy‘ ¤Ã£Ìš€¶,¶,‘¶Lˏ‘ ¤šŒ\¶»‘9œsÏY‘*¶ÂŒy¤ ¤‘€¶,¶Žµy‘ –€‘Œ˜”Y–•¶D”•—. . $. œsÏY‘C˜Ž–{Æ7¶ÏYšJ˜»‘ ¤ ”•™.™.”•–›”{µ‘J˜£¥šJYŽÇ–mÆZŽ–Y—s”i˜™›šœŽ”i–yÒ{ÄLÏY‘ Xº

(20) ¡. $. ¦ ß ”YÏY”Y–Y‘ –Y¨ ³ÞYÞ\¼ §CœsÏY‘Z¤”i–€¤ ‘J{œH”i— ¶»‘㥗s±”Y˜ƏšJ–YŽ mšœsŽ”Y–. œc”. ¶πšJ˜‘¶Lá.Ž"œÏ « ‘ £—± ˜Əš –YŽ ŽÇ–YÆ.¡‚šJ¶. ¤ š˜˜Âà. . . “>ŒYœ<—s”i˜>œsÏY‘ Xº

(21) ¡x¨

(22) œsÏY‘ZŽ–Y—s”i˜™.šœŽ”Y–r’YŽÇ——cŒÅ¶Ž”Y–ÚŽ¶XŽ™›•£Ž¥¤ Ž"œ£Çà. . ”€ŒYœ œsπ‘Z¤ £š{¶·¶Ž—Ž¤šœŽÌ”i–r”Y— œsϏ‘Z’Yšœš{Ò ”i‘J˜»šœ‘ ’ØœsπšJ– ¶Cœs”(œsπ‘Z”€µi‘J˜£šJYŽÇ–YÆ. . . . ˏ‘œá.‘ ‘ –.œsÏY‘*¤ ”Y–¶‘¤ŒYœŽµi‘Ö–€‘Œ˜”Y–•¶‡Ò•ÄLϏ‘ Xº¡N˜‘JY˜»‘€¶»‘ –œ¶>š ·¶Âœs˜ÂŒy¤œŒ˜»šJ£Y˜”Y—ÂŽ¥£¥‘ C¦ž ˜ŽË¶ ”€µ;‘œ@š £Ò¸¨ ¼Í%$m² §¨Õ˜»‘¶ÂŒy£"œsŽ–{Ƃ—˜”•™ ¬H‘ £šœ‘ ’. œsÏY‘×™*Œ£¸œŽ£¥‘×£”•¤šÃ£šÃ£¥Žƕ–Y™›‘ –œ ”i—>œsÏY‘غ“. $. šYY˜”š ¤J𑍶›šJ˜‘. $ $. $ $. ¶Âœs˜sŒy¤‡œŒ˜š£. $. ¶sœŒy’à€¨Öá֑. —˜šJƏ™›‘ –œ¶. ¶‘¤ÃŽ—Ž¥¤ Ž"œsàâŽÇ–®œ‘J˜™Z¶. $. ¶ÂŒy™A™›šJ˜Ž ‘ ’‚ŽÇ–‚¦ž¯”Y– š £¥‘ ±c¹.ŽÌš °‘œ.š £Ò¸¨ ³ÞYÞ%$ §¨<šJ–Y’‚‘ɏš ™.£‘{¶›¤ š –. —s”{Œ–€’SŽ–.¦žX”i– š £¥‘ ±c¹.Ž¥š X‘œLš£Ò¸¨ ³ÞYÞY²%& ¡ © –ãœsÏY‘äY˜‘¶»‘Öœ. ‘ –Y¤”•’Y‘ ’P¶Âœs˜ÂŒy¤œŒ˜šJ£ —˜,šJƏ™›‘Öœ¶Ò. ’Œ˜Ž–{Æ. ÏYšJµi‘ œsÏY‘. Ëy‘. Œ–œ‘ š –Œh‘œÅš £Ò¸¨ ³ÞYÞ%$ §Ò. ’Y‘ —Ž–‘ ’. š. –€‘á. œs˜šŽÇ–YŽ–YÆÒ;ÄkÏYŽ¶. ”•—F¶»‘ ‹Œ‘ –€¤ ‘ ±o¶sœs˜ÂŒy¤œŒY˜»‘. ¯º¡. ËYàӚ ££Ì”€á.Ž–YÆ. Y˜”•¤‘ ’Œ˜‘. ˜‘J£¥šJœsŽ”i–¶ÏYŽÒ. $. ƏšJ¶. Ž–ãœsÏY‘äY˜”{œ‘JŽ–. à€Ž‘ £¥’¶äœs”GŽ–Y¤˜‘ š¶,‘ © –âš ’Y’YŽ"œŽ”•–€¨¢á֑. ¤JπšJ˜š ¤œ‘˜oŽ šœŽ”i–°”•—>œsÏY‘(™Ö” ¶sœ —˜‘ ‹Œy‘ –œ*¶‘¤ ”i–€’YšJ˜àP¶œs˜ÂŒy¤·œŒY˜‘¶¯—s”{Œ–Y’. Ž–rœsÏY‘(£””Y¶¨. œsÏY‘6£ŽÌˀ˜šJ˜à. ¤ šJ˜˜Ž¥‘ ’. ”{ŒYœFš. .  Ò YÒÛ¨\œsÏY‘AœsŽƏύœ. . œŒ˜–¶¨YŽÇ–Xœ‘J˜™A¶D”—\£”¤ šœsŽ”Y–.Ž–¯œsÏY‘ Xº¡âš –Y’¯º“㶎Ə–šœŒ˜‘¶Ò © –Øœsπ‘(¶‘ ¤ ”Y–Y’ —˜”•™. œsπ‘. £Žˀ˜šJ˜àӔ•—;¤ ”i–Y—s”Y˜™.šœŽ”Y–Yš £Z¤ £¥š¶¶‘¶Ò ¹ÖŽÇ——‘J˜»‘Öœrš–Yš £Çày¶‘{¶×á.‘˜‘䐏‘J˜—s”i˜™›‘ ’ãËYàFŒÅ¶ŽÇ–YÆ. ™*Œ£¸œŽµyšJ˜Žšœ‘Ñ™›‘œsπ”•’•¶. . &. ¶sœ‘J¨

(23) á.‘›‘JÉ{œs˜š ¤·œ‘ ’׎–Y—s”i˜™.šœŽ”Y–;”i–rY˜”œ‘JŽ–r¶,‘ ‹Œy‘ –Y¤ ‘ ‚¶Âœs˜ÂŒy¤œŒ€˜‘S˜»‘ã̚œŽÌ”i–¶ÏYŽÇ. ¶ÂŒy¤ Ï. ¦ ֔œ‘J££ŽÇ–YƏ¨ ¼ÍY½Y´ §ÐC¦Ž§Aœc”. š{¶WÏYŽ¥‘J˜šJ˜»¤JÏYŽ¥¤š £°¤ £Œ¶œ‘J˜Ž–{Æ. Ž’Y‘ –œŽ—à. ”•—Z¶‘ ‹Œy‘ –€¤‘. š –Y’. ¤šÃ–€”i–YŽ¥¤š £°¤ ”i˜˜‘J£šœŽ”Y–. š –Yš £Çày¶ŽÂ¶. Y˜»‘×s‘˜‘ –Y¤ ‘{¶7—s”i˜7‘š ¤JÏã¶sœs˜ÂŒy¤œŒ˜šJ£X¤ £¥š¶¶»¨¯¦ÂŽŽ§Aœ”.

(24)  

(25)  "! $&%'(%*)(+-,./%10 +2,.&34065 ,7$8% 96:,;<0 =7% .&5%15>=706??@%A?BC?@3ED&,F&D&=7,FGD',.AFH'ID&%JF/=3LKL0>=M?@% 96:<% .&5 %JNO?I'I)P:<5':/)% $&%*Q/%*.R$G% .R5 %S0 .&$&BUT@,,7,WVX'(3Y%ZA'I)@0 5[']\5 3&.6'I)06?']^I0 5'(3A)_?`a3&Q&Q&3?,W.bFY5 %*)P'(0 ,.c?P'I)I:<5':/)0*=dQ&)36'e36'fbQ% ?P:&K?@%'?g0 55 3L)@$A,W.bFM'I3h'ID&% ,)i?@% 96:<% .&5 %jNk=3G50>=?I'I)P:<5':/)(% $&%*Q/%*.R$&%>.R5%Al. monqpsrtuvAw(r

(26) x(yzr

(27) {}|4psu&t~}€q|iy b‚ƒA„ 2†&‡/„ˆ‰ Š&‹‡Š&Œ&‡Š&ŒA7ŒAŽ/Œ&‡&}†‘-’b“]”•ˆ†&‰–‡dWˆ[‹— 7‹˜ˆ[‰* ™›š 3c$&0'(0KL0*.Aœ?. š %)%:?@% $c,.Y3R:/)ž?P':<$6fRB Ÿ[¡¢X£c,.&5 =:<$&,W.&F¥¤&¦G§¨.R3L.R©P)% $6:<.&$&0 .6'ªQ&)36'(%,.. ?P'I)I:<5[':/)%?i%ZA'I)0 5'(% $-^)3/+«'IDR%C¬q)36'(%*,.M­®0'(0°¯ 0 .bœdTP¯±%*)+z0 .d%'²0>=³l"B/´/µ&µ&µAVB0*.R$-Ÿ¡¢¶dB0C)@% 5%>.'i?@%'(B ,./5 =·:<$&,.&FS¸&¸¹/º».R3L.R©P)% $6:<.&$&0 .'¼Q&)36'(%*,.½?I'I)P:<5':&)@%6?l ™ D&%?_%¾?P'I)P:<5':&)%6?@B°?% =%5'(% $X^)3/+s'ID&% ¬­M¯±© ¿}À ¬ ¿ ­¼¯. $&0'(0K/06?@%STÁ23&FA:<5*D&,Â0 .&$Äà œ/,WfL0 +20B ´/µ&µ&ºAVBdD&0$Å´ÇÆ. Q&)%6?@%*.6'(%$È=7%6??2'IDR0>.ɺ&µAÊ. 3&)XK/%'7'(%*)X)%?3&=":&',·3L.<l ™ D&% f. 3G^d?_% 96:<% .&5 %H,7$&%>.',Ë'PfÉ0 .&$ž0E+z,.G,7+20 =¼)3/36'2+Ì% 0 .«?@96:<0*)%H$&%*;/,70'(,3G.. TeÍ_ÎhŸ_Ï/V°3&^¼¸µÐÆÑ0 ^'(%*)}Q/0 ,W) š ,?% ?I:/Q/%*),+zQ/3?,"',·3L.<l À 0 5*D1?P'I)P:<5':R)%z3L^o'ID&%z$&0'(0K/0 .Aœ? š 0A?Ò% .&53G$&% $ ,.6'(3d3A:/)j?I')P:<5':/)0*=˜0>=Q/D&0*K/%'_l ™ D&,?Ó=0''(%*)•,?Ó5 3G+ÔQ/3˜?@%6$®3L^g0z?%'²3L^Ò¸¤Õ?P'I)P:<5':R)0 =GQ&)@3R'e36'fAQ/%?}5 0 ==7% $ ¬q)36'(%,W.2¯±=3/5*œ

(28) ?ÖTe¬¯¼?B²?@% %h×q,WFA:/)@%Õ¸VÒ0K/=7%C'(3U0*Q&Q&)(3RZR,+®0'(%M=3/5 0 ==WfUQ&)36'(%*,.Uº6­Ø?I'I)P:<5':/)%6?l ™ D&%Õ¸¤ ¬¯¼?}5 0 .d0Q&Q&)3RZ/,7+®0'(%M=3G50>==f2'ID/%hQ&)36'(%,W.dK/05*œLKL3L.R% š ,"'IDd0zD&,F/DdQ&)% 5 ,?,3G.dTÍÎMŸ_ÏUÙXµlÚ¹&´UÆ V}T$&% ¯Ò)%;L%*).&B´/µ&µG§Vl ™ DR%*fU0*)%z=70KL% =%$ K&fU=7%''(%*)?Ó^)3G+ÜÛU'I3iݼl À 0 5D-¬¯a3&^j§k5 3&.G?@% 5:&'(,·;L%M)%6?,7$6:<%A?},P? $&% ^P,./% $hK&fdÞÔ$&,D/% $A)0 =/0 .AF/=%A?gT. φ. 0*.R$. ψ. V[l*ßz%*.R5 % B&Q&)36'(%*,.zº6­Ñ?P'I)P:<5':/)%6?g0)% %*.&53G$&% $M,.z0h?I'I),.AF®3L^. 5*DR0*)0 5'(%)?ÒTPàlÚ¡&lËBL'IDR%h¬

(29) ¯¼?(VB˜'IDR%-53G$A,.AFUQ&),.&5 ,QG=7%ÌKL% ,.AFUK/06?_% $U3&.d)3&36'i+Ì% 0 .J?96:<0*)%z$&%*;/,70'(,3L.U3&. 0*.bFA:=70*)z;/0 =:<%6?®Tá/5 D6:<5 D&D&0*)@$6'z%'z0=lËB-¸â&â&¤AVl À 0 5*DHQ&)36'(%*,.8º6­ã?I'I)P:<5':/)%Õ3&^ 'ID&%J.&3&.&©P)@% $6:.R$&0 .6' $&0'(0KL0*.Aœ/BÓ0¾?P'I),.AFª3L^°¬¯¼?B š 0A?Ô5:&'¼,.6'(3X3A;/%)ä=·0*Q&QG,7.AFH^I)0*F/+®%>.'?Ô3L^gåÄ?I:<5 5 %A??,;<% ¬¯¼?lqæä.]3A:/) ?P':<$6fRB

(30) åaç½´bè°é}¸B š ,Ë'D1èÇçêº&B•àlÚ¡&lËB•^)0FG+®% .6'?Ô3&^M¦J¬

(31) ¯¼?[l²ÃØ^I)0*F/+®% .6'¼3&^•ågé¹80 +z,W.R3E05>,7$G?z,? 06?_?3/5>,·0'(% $-'I3U% 0 5DÕ?P'I)I:<5[':/)0=

(32) ^)@0*FG+®% .6'Ó0.&$d,e?Ö$&% ^P,.<% $2^)3G+Ç©èÒ©P´2'(3déGè}é´UT,W.k3R:/)Ò?P':<$6fRBAå•é¹dç ¸&¸Vl. #.

(33)  

(34)  "! b‚&„ȐˆŒ&‰g‘†AˆiŽ/‹–7Š&–‡ dŒ –Ž&ˆŒAˆU†‘zˆ‹— ‹ˆ[Œ ”•ˆ†&7†& ”i‰*

(35)  Ž&ˆ[–Šiˆ†&‰–‡ ½†&Š&‰ ™ D&%¼\*ßMfAKR),$-¬q)36'(%,W. 83/$&% =`zTeß¼¬HV},?}0 .z:/.?P:/Q/%*);/,?_% $d5 =":q?P'(%*),.bFÕ+®%'IDR3G$lAæ'gQ/%)^I3L)+2?g'ID&% 5 3&+MQ&)%6??,·3G.13&^Ö'IDR%Õ?P'I)P:<5':/)0*=g,W.&^I3&)+®0',·3L.ÕK&f¾%R?I'(0K/=,?D&,.&F]0 =7,K&)_0*)f13/^°3A;/%)ä=·0*Q&QG,.&F8?P'I)P:<5':/)0*= Q&)36'e36'fAQ/%?UT$&%¾¯Ò)%;L%*).ž0 .&$Eßz03R:&'eBC´/µ&µ&µVl ™ D&%X=,K/)0*)fž3/^ ?I'I)P:<5':R)0*=¼+z3R'(,^ä?U,?U%6?I'(0K/=,?DR%6$ $6:/),.AFd0°'I)0 ,.&,.&F2Q/D&0A?%Al ™ D/%°'I)0 ,.&,W.bF š 0A?Ó5 0*)()ä,7% $d3A:A' š ,Ë'IDÌ'IDb)% %M96:<0)P'(%*)?Ó3&^

(36) 'ID&% Ÿ¡¢›£®T*¸µG§bBºA¹/µ ^)0*F/+®% .6'?V[l ™ D&% ;/0 =,7$&0'(,3&.Õ?P'(%Q š 06?ÓQ/%*)^I3&)+z% $d3&.-'ID&%M=% ^'Ó96:<0*)I'(%*)i3&^›Ÿ¡>¢²£®TºA¹/B¸¤&º-^)@0*FG+®% .6'?(V 0*.R$-,"'?i?I'(0K/,=7,"'If š 0A?g5 3&.&^P,)+®% $ š ,"'IDhŸ[¡¢G¶®TP´/¦&¦&B¤›¸ Þ ^)0*F/+®% .6'?V[l. ¶ ¶ £AÍÛ/à /  à!"$#%z¢'&/¡(*),+6ÍàWÏ-iÍ.#/¢W¡ à. /0#AÏ/¡1. ™ D&% Q&),./5>,QG=7%M3&^

(37) 'ID/%°'I)0*,.&,.&Fd,?}$&%6?_5*),K/%$ ,.-×q,FA:/)%h´l ™ DR%±ß¼¬ã,?}0 ),W.&Fk3L^o./%:/)3L./?BGà(lÚ¡&lËB0 5 =3?% $s=,./%0*)ž./%:/)0 =X.R%' š 3L)œ. š ,"'ID. 5 3&.&.&% 5'(%$s%Zb'I)% +z,"',7%6?êTכ,FlU´/0*Vl. ™ D&%Üß¼¬. 5 0 .. K<%. 5 3&.G?,7$&%*)%$J06?±0-Q&)3AK/0K/,7=,e?I',75zQ&)36'(%*,.J53G+MQ/3?% $J3&^32Ø?,"'(%?l À 0 5*D1?,"'(%̟Ô,? $&% ^I,W./%$ÂK&fÐ02=0 š. 3G^. Q&)3AK/0K/,7=,"'Pf$4 Ÿ Te¬¯°V@B•5 3&)I)%6?Q/3&.&$&,.AFJ'(3 'IDR%d$L,?P'I)(,·Kb:&'I,3G.13&^i'ID&%5a¬

(38) ¯¼?¼53G+MQ/3?,W.bFJ'ID&%Õ?P'I)I:<5':/)0*= 0 =Q/D&0*K/%'ÖT,.U3R:/) ?':<$6fRB65Sç긤AVl ™ D&%hß¼¬, ´AK&V[l

(39) Ã. 53L))@%6?IQ/3L.R$G?i'I3J0M+z0'I),ZÂ3&^i$&,+®% .G?,3/.72aZ 5aTe×q,Fl. ?P'I)P:<5':R)0*=Ó5 =0??BoàlÚ¡&lËB•02.R%:/)3&.15 =:?P'(%*)?¼^)0 F/+z% .6'?M?DR0*),.&F»?,7+2,7=0)h=3/5 0 =°?I'I)P:<5[':/)@%Alæe'Ò,?. $&% ^P,./% $ÕK&f®åS?P:<5 5%R?_?,;<%2=0 š ? 3/^iQ&)3AK/0K/,7=,"'If1T,.Â3R:/)¼?P':<$6fRBGåžç8¦AVl ™›š 3ª?I:<5 5 %6?_?,;<% ?P'I)I:<5':&)0 = 5 =0A??@%R?40*)@%Ü3A;/%*)=70*Q&Q/,.&Fs?,./5%'IDR%f. ?DR0*)%aTWåÓ©*¸VÈ?,Ë'(%6?l ™ D6:?@B 'ID&%Ç?P:<5 5 %A?_?,·;<%a.&%:/)3&.?40*)%. $&%*Q/%*.R$G% .']0*.&$c?DR0*)%O53G+z+z3G.¨,./^I3L)+z0'(,3&.l ™ D/%È'I)0*,.&,.&FÇ,W./5 =:<$&%A?¾' š 3Ç$A,?P'I,./5'H?I'(%*Q?8z0*. ,7$&% .6'(,W^I,750',·3L.MQ&DR0A?% 0 .&$z0 =3G50>=/% .b)ä,·5>D&+®% .6'qQ&DR06?_%Al. T,V9&/¡-àÏ/¡:<¢Wà %&à;*Û<¢à#9ÒÝ&&Û&Ÿ¡. 8. À 0 5*DJ?I'I)P:<5':/)0*=›^)@0*FG+k%*.6'Ö3&^

(40) åê?P:<5 5 %A?_?,·;<%h¬¯M?Ò,?i'(0*œ/%*.d)0 .R$&3G+z=f. ,.J'ID&%-'I)0 ,.&,.&FE?%'_l ™ D&%d+z3?P'¼?,+2,=70*) Q/0''(%*).JQ&)%?%*.' ,.Õ'ID&%2ß¼¬, ?53L)%z,?±02=3LF/0)ä,Ë'ID&+. ,?z?_% 0*)5 DR% $1Te×q,WFl´/5*Vl ™ D&,P?. 3L^}=,œ/% =,DR3G3/$Õ)0'I,3/Bo0*.&$&B›+z%0A?P:/)@%6?j'IDR%20 $&%96:<0 5*fÂ3G^}0 ?I'I)P:<5':/)0*=o^)0*F/+®% .6'. š ,"'IDk0hF/,·;L% .d.&%:/)3&.dTIàlÚ¡&lÚBAå½?I:<5 5 %6?_?,·;<%M=70 š ?}3G^oQ&)@36K/0*K/,=7,"'PfbVl ™ D&%M%*ZRQ&)%6??,3G.k3L^›'IDR%-?53L)%=<>;TeŸV 0' 0jF&,;L%>.¼ßh¬ã?,"'(%jŸjTeŸi;/0)@f/,.&F®^)3G+ظ•'e3?2¼V›,?8.

(41)  

(42)  "!.   

(43)          +   =   . =−.      53L)I)%6?(Q/3L.R$G?-'e3»'ID&%J¬›)(36'(%*,.H¯ =35œÈ=·3G5 0'(% $E,.EQ/3?,"'(,3&.  . ;/0)@f/,.&F1^)3G+¥©è'(3Jé/è¼l. 4 0 . 132 / -. ' $ # ! % & " +.  =+. ,?}'ID&%2^)@% 96:% .R5fÂ3/^. ,?›'IDR%°)% ^I%*)% .&5 % ^)% 96:<% .R5f-3G^. )+* (. )+* (. T*¸_V ,W.H'ID&%H?P'I)P:<5':/)0*= ^)0*F/+®% .6'(B ,.ÕQ<3?,"'(,3&.JTeŸ[é,CV ,.d'ID&%Ìß¼¬žl. B&àPlÚ¡&lËBA,"'?²3RK<?%*)P;L% $-^)@%696:<%.&5*f®,W.¼'ID&% $&0'(0KL0 .Aœl ™ D/%. ,7$&% .6'(,W^I,750',·3L.]QGDR06?%15 3&.G?,?P'?z,.ž?% =7% 5'(,.AFX'ID&%UQ/3˜?,'I,3&.¾Ÿ 3LQA' B²'IDR%ÕQ/3?,"'(,3&. ?53L)%. š ,"'(D¾'IDR%¾+®0*Z/,+Ì:˜+. 6 BDCFE :?>A@ 9;:=< 86 7 5 l Á®3¨36'IDR%*)XQ/3?,"'(,3&.¨D&0A?ª0ÈK/%''(%)H0 $&% 96:<05*f¨^I3&)¾'IDR%ÈQ&)%?% .6'(% $ [ ( )] =. ^)0*F/+®% .6'_l. T,,V. 9&/¡=1# ;*Û>1¡&Íà;&GÎÔ¡:<¢äÝ&&Û&Ÿ[¡ 8. ™ D&,?oQ/D&06?_% 53L./?,e?I'?g,W.d?=,FGD'=f®+z3/$L,^Pf/,.&FM'ID&%j¬¯É$L,?I'I)ä,Kb:&',3&.?. 3&^

(44) 'ID&%z?P'I)P:<5':/)0*=5 =706??Ó5 3&))%6?(Q/3L.R$L,.bF-'(3Ì'IDR%Ì?,Ë'(%CŸ 3&QA' B,.®3L)$&%)›'I3d,W.R5*)% 0?%C'IDR%h=,œ/% .&%A??gK<%' š % %*. 'ID&%E¬¯¼?]$L,?I'I)ä,Kb:&',3&.a3&^X?,"'(%ɟ 3LQ'. 0.&$O'ID&%½Q&)%A?% .6'(%$Ü^)0*F/+®%>.'1Tכ,FlÕ¸$AVl ™ DR%È% .b)ä,75 D&+®% .6'. Q&)3/5 % $6:/)%d,?Ì0*Q&QG=,7% $¾'e3Ð'ID&%MåO¬¯Y$&,?P'I),KA:&'(,3&.?M^I3&)C'IDR%Ð?,Ë'(%6?M^)3/+. TeŸ 3LQA' ©7èjV '(3XTeŸ 3LQ' é/èjVlqæP' ,?. 5 0*)()ä,·% $z3R:b'o0?o^I3L==3 š ?

(45) 8. L OUPVQSR T I JMK + _ aUbVcSd \ ]M^ +`. L OPQSR I JK +N +α G H ← H. +α. [. _ abcSd \ ]^ +` ← Z [. XY. =. XY W. TP´&V. % =?% š D&%*)% T'ID&%2¸ §Ô36'ID&%*)›¬¯¼?V[l. +α. 0'¼QR3˜?(,"',·3L.ªTfe 3&Q6' égAVBgJ;/0*)fR,W.&F8^)3G+ ™ D&%6?@%d% 96:<0'(,3L./?¼0 ==3 š. ,W^. ©fh¨'(3Héih¼l ™ DR%¾?f/+MK/3G=. ←. ?Q/% 5 ,^(,%?z\ ,?z5 D/0 .AF/% $H,.6'(3&`&l. 3L.R%-'(3J,W.R5*)% 0A?@%Ì'ID&%d^)% 96:<% .R5>,7%A?±3G^•'ID&%d^)0*F/+®% .6'}Q&)36'(%,W.UK/=3G5œÐ¬¯. g. ,.. =3/5 0'(% $M^)3/+je 3&QA' ©kh»'(3le 3&Q6' émh BG0 .R$Ô'e3-)%$6:<5 %Ö'IDR%°^)% 96:˜%>.R5 ,%?g3G^'ID&% 36'IDR%*). 'ID&%h?,Ë'(%6?g3&^˜'IDR%jßh¬. ¬¯¼?MTonqpsrDtvuxwkrDt=wj.R3R'±3AK?@%*)P;/%$AVl,83&)% 3A;/%)B 'ID&,? 'I)0.G?^I3&)+20',3&.]% .G?P:/)@%R? '(3Xœ/% %QÐ'IDR%Õ^)% 96:<% .R5>f ;/0 =:<%A? š ,"'ID&,.h'ID/%°)@0*.AF/%zyµ&B&é}¸v{o0*.&$ 'ID&%h?P:<+a3&^›^)% 9A:<%*.R5>,7%A?g% 96:<0 =A'(31¸ l ™ D&%1Q/0*)0 +®%'(%*). α. ,?2'ID&%¾'I)@0*,.&,W.&Fê5 3/%*^I^,75 ,% .'_liæ.&,"'(,0 =7=Wfž^,Z<% $ž0'-0Ð;<0 =:<%. $&% 5*)@% 06?%?g$6:/),W.&FM'IDR%Ö'I)0*,.&,.&F®0 5 5 3&)$&,.AFM'I3h'ID&%°^I3/=W=·3 š ,.AF®% 96:<0'(,3&.8. α|. TA}&l ~gl}µlÚ´/µAVB°,"'.

(46)  

(47)  "!. α=& š D&%*)%. α' +. % $. uz$&% .&3A'(%6?z'ID&%H.6:<+MK<%*)U3L^d^)@0*FG+®% .6'? 0>=)%06$Af4Q&)%A?% .6'(% $E'e34'IDR%¾ßh¬. Tº6V. 0 .R$)(½'ID&%¾'(36'(0*=. .6:<+MK<%*) 3&^}^P)@0*FG+®% .6'?±,W.d'ID&%M'I)0 ,.&,W.&FÐ$&0'(0K/0 .bœl

(48) ÃM?°'IDR%Ì'I)0,W.&,.&F1,? ,"'(%*)@0'I,;<% B•?%*;/%)0 =g5fL5 =%A?±0*)% .&%56%??_0*)f¼'(3-3AKA'(0,W.Ì0h?P'(0K/,7=,   0'(,3&.z3L^'IDR%j¬

(49) ¯É$&,e?I'I),K&:&'I,3&.-=70 š ?l ­z,^^(%*)% .6'qQ/0*)@0*+z%'(%*)_?•,+zQ/=,75 0'(% $ ,.h'ID&% 96:<0 =7,"'PfÌ3G^'ID&%j'I)@0*,.&,W.&F®0*)@% $&%;/% =3&Q/% $-,.2?I:/Q&QG=³% +z% .6'(0*)fÌ$&0'(02¸l. *,+*,+*,-/.1032. t r,4 } 0 6} 5 ue rop u7}98;:< uVt nw5w=5 ~. > 0*Q? š %*)%U,W.'I)3/$6:<5 % $¾,.'I3»?I'I),.AF?¼3/^Ö¬q¯c?_%96:<%>.R5%6?¼$&%A?5*),K/,.&FE?I'I)P:<5':&)@0*=i^)0*F/+®% .6'?l ™ D&,P? ?P'I)@0['(%*FAfU=7%0 $G?i'(32'ID&%z$&% ^P,./,"'(,3L.U3/^i0z+Ì:<="'(,QG=7%2?P'I)P:<5':/)0*=q0 =,FG.&+®% .6' š ,"'IDdF/0Q?l›á/3/B

(50) ,"'ÓQ/%*)+z,"'_?i'(3 '(0*œ/% ,.6'I3®0 5 5 3A:/.6';L0*),0*K/=%¼=% .bFA'ID-^)_0*F/+®% .6'o,./?P'(% 0 $®3L^q3&.&=Wf®^,Z<% $z=% .bFA'ID2T?•V[l ™ D&%°)P:<=%A?g0 $&$/% $z,. 'ID&%j'³)0*,.&,.&F®0*)% %*Z&Q&)%??% $z0A?8AT,VoF/0Q?g0*)% ,.6'I)3/$6:<5 %$-0'q3L.R%°Q/3˜?(,"'(,3L.Ì3L^'ID&%h?I'I)P:<5':/)0=G^)0FG+®% .6'(B 0*.R$Ì'ID&% ,)i=7% .AFA'ID®50 .-;/0)@fk^)3G+. ¸j'(3Õ§bB0.&$2T,,Vi0¼5:/'I3&^P^A@Ü,?i^,Z<% $M'(3Õ?% =% 5'g3&.&=·fz'IDR%-?,FG.&,^,750 .6'. F/0*Q?[l ™ DR%CF/0Qd,?Ó5 3L./?,7$&%*)% $M'(3ÌK/%M?,F/.&,^,75 0 .' š D&% .M'ID&%¼3LQ'I,W+®0 =›?@5 3L)@%h3&^

(51) 'IDR%C^)0FG+®% .6' š ,"'IDzF/0*Q ,?B@sTIç

(52) ¹&V¼',+®%6?®D&,WF/D&%)h'ID&0 .¾'IDR%¾+®0*Z/,+20 =¼?5 3&)%13RKb'(0*,.&% $H^I3&)h'ID&%1^)0*F/+2% .' š ,"'ID&3A:&'¼F/0*Ql ™ 3 5*DR%65œÐ'IDR%2)% =%*;/0 ./5 %d3&^i'ID&%d,W.'I)3/$6:<5'I,3&.13L^}F/0*Q?¼,.Õ'ID&%Õ?I'I)P:<5':/)0*=g^)0*F/+®% .6'?B š %d06??@%R?_?% $Õ'ID/% ;/0)ä,70'(,3&.G?±3G^•'IDR%-¬

(53) ¯Ñ0 .R$ª?@% 96:<% .&5%2,.&^I3L)+®0'(,3&.J5 3&.6'(%.6'?°KL%' š %%*. 'ID/%MßMfAK/),$Õ¬q)36'(%*,. »  3G$&% =? KA:<,=Ë' š ,"'IDd3&) š ,"'ID&3A:&'gF/0*Q?[l ™ 3 ,./?P:/)%M0Ô5 3L.',.:,"'IfU3&^›'ID&%z?P:<5 5 %A?_?,·;<%M=3/5 0 =Q&)36'I36'fbQ/%A?B0*.R$d0 =e?@3 $&,W+®,.G,?DM'ID/%h,.G^I=:% .R5 %M3&^ š % 0œG=f2)@%*Q&)%A?% .6'(%$ ?P'I)I:<5':/)0*=^)_0*F/+®% .6'?B<$&% $L,·5 0'(% $zQ/0*)0 +®%'(%*)?ÓD&0*;/% K/%%>.Ì0>=?@323&Q6'I,+z,!b% $zTä?@% %h?P:/Q&Q/=7% +2% .'(0*)fz$&0'(0°´&V_l. CEDF,GIHKJ

(54) LNMOL,P QRMS"TL,QSVU,WXUYBQJR9Z;[\,MOS] ^9MU,QVR SW`_aU,],RbSWcQVR6MdfeIUYBbU,P L,bgeQ=MOhP QhMR ™ D&%j¬¯¼?}?Q/% 5 ,7^,75>,Ë'Pf®0'o%0 5*Dhß¼¬3ã?,Ë'(%. e. } k<B š 06?g96:˜0 .6'I,^,7% $MK&f®0 .z% .6'I)3&QAfR©$&%*),;/% $z+2%06?I:/)%ji. wl }&lËB›\% 96:<,·;L0 =% .'°.:+MK<%*)±3G^•¬¯M?(`&læP'?±%Z&Q&)@%R?_?,3G.J,I?j'IDR%d%*Z&Q/3&.&% .6'(,0 =g3G^ á/D&0 .&.&3&.1% .6'I)(3LQAfB8kTfeV Tá&D&0 .&.R3L.RB²¸âA¹ÞVl. #.

(55)  

(56)  "!.    = 

(57) [ ( )] š D&%*)%. . š ,"'ID.            =−     .  . =. TI¹&V. =. e T Ag V¼$&%*.&3A'(%6?°'IDR%2^)% 96:<% .&5*f]3/^Ö'IDR%-¬q)36'(%*,.J¯ =3/5*œ g¾=·3G5 0'(% $J,W.ÂQ/3˜?,"'(,3&. e®3G^i'IDR%-ßh¬. "!. T Òç}¸¤-^I3&)g3R:R)j?'I)P:<5':/)0*=<0 =QGDR0*K<%'IVl ™ DR% i. } kz;/0 =":˜%C+®% 0A?P:/)@%6?o'ID&%¼0;/%*)@0*F% .6:<+MK<%*)Ó3L^ 3L^¬

(58) ¯¼?gQ/%*) ?,"'(%Alæ'i;L0*),%6?°KL%' š %%*.E¸¼¬

(59) ¯ÑT w l }&lËB3L.&=fÐ3L.R%̬¯¨,?¼3AK?@%*)P;L% $AV 0 .&$8¸¤ ¬¯h?±TAw(l }Rl"BG'IDR%¾¸¤ ¬¯¼? 0)% il}kÌ;L0 =·:<% +z%0*.?g0°D&,F/D&=WfÌ$&%'(%*)+z,./% $2?,"'(%Al. %;L%>.&=f®$&,e?I'I),·Kb:&'(% $AVl ™ D&%*)@%*^I3L)@% BG0°=·3 š. $# &% bVUN\gL,b/L,WL,b [eSeIUYfQVJ

(60) R eOR(',hR WP R6GeOQ=MOh

(61) PQhMR MOR bL,QVSU,WeJS ) *,++*N+$,-- 0 w5rln/. w"0 2 t=r 2 }65se w uFwk}ve n/1krN5 ~ u 7}98 :< e=woux} e 2 %H0 .&0 =Wf b% $E'ID&%H$&,?P'I),KA:&'(,3&.ž3L^M'IDR%H0>+z,.&3ê0 5 ,7$˜?U=3/5 0'(% $½,.E'IDR%H5 % .6'I)0*= Q/3?,"'(,3&.ž3L^M'ID/% ^)0*F/+®% .6'?•'(3dQ&3&,.6'Ó3A:A'Ó0 +z,.&3U0 5 ,$2Q&)@3LQ/%*.?,Ë',%A?Ö0>=·3G.AF2'IDR%Ôß¼¬ ?,"'(%6?[l 2 %-53G+MQA:&'(% $d0*.U0 +z,./3. CED NG. 0 5 ,$J3/5 5:/)()%*.&5%-+®0'I),ZÂ3G^i$&,+®% .G?,·3G. i¨ZU´/µÂT š ,"'ID`i¨ç긴/µAVB š D&,75 DdF/,·;<%A?Ò^I3L)Ò% 05>D1?P'I)I:<5':&)0 = 5 =0A??8'ID&%¨0 +2,.R3s0 5 ,$Ø$&,?P'I),KA:&'(,3&.Ø3&^X'ID&%¨5 % .'I)0 =J)%?,$6:<%bl ™ D&%?_%¨3G55:/))%*.R5 %6?. 43. š %*)@%«'ID&% .. .&3&)+z0 =,!b% $z,.6'(3 Ó©?53L)%?g06?o^I3G==3 š ?8. @?. ×q3&)10*.0>+®,.&3a065 ,$ S,.Oßh¬. < : 5>8 < 9 6 >8 < 7 5 = ; 5>8 = − < Tä§ V 9 6 > 8 =7 5 Q/3˜?,"'(,3G. eB;5 e T A ? V]$&%*.&3A'(%6?1,"'?Ð3RK<?%*);L% $S3G55:/))%*.R5 % B (p AbT ?bV¾,Ë'?. )%*^(%*)% .R5 %X^)% 96:<% .&5*fÉTAwl }&lËBi'ID&%X^)% 96:<% .R5f43AK?%)@;L%$É,.H'ID&%]$&0'(0K/0 .bœ&VB 0*.&$ ^)0*F/+®% .6'?U06??@3G5 ,0'(% $E'I3»'IDR%E?,"'(%. el. ™ D:?B°'ID&%J'(%*)P+. F C J E GIH D B. i ? 'ID&%X.:+MK<%*)k3L^. 5*3&))%?Q&3&.&$G?®'I3E'ID&%H%ZRQ/% 5'(% $.

(62) ?. 3/5 5:/))%.&5 %¼3L^›'IDR%h0 +®,W.R3Õ05>,7$ d0'q'ID&%M?,"'(%  e l ™ 32+®%06?P:/)@%±'IDR%-?% 96:<% .R56%¼,W.&^I3&)+®0',;/,"'Ifk3G^o0 ßh¬ ?,"'(%leB š %z$&%'(%)+z,W./%$ š D&,75 DÂ0>+z,.&310 5 ,7$G? š %*)%z3R;<%)©}0*.&$2:.R$&%*)©P)@%*Q&)%6?@%*.6'(% $l/ë'IDb)%6?DR3G=$ š 0A?. K3. ^,Z<% $d0'g´l§b¦dT0K?3&=":&'(%C;L0 =·:˜%M^I3L)Ö0h),?œU3&^ ¸ÊJVl ™ DA:?B Ó©ä?53L)%?iF&)% 0'(%*)²'IDR0*.2´l§b¦dTP)@%6?Q/% 5'I,·;L% =Wf =3 š %). 'IDR0 .. N/´l·§b¦AV. 5 3A)()%6?QR3L.R$. 'e3. 0*+z,.&3. 05>,³$. 3A;/%)©P)%*Q&)@%6?%*.'(% $. TP)%6?(Q/% 5'I,";<% =Wf. :.R$G%)©. )%*Q&)@%6?%*.'(% $AVl&æ+MQ/=,75 ,"'(=WfLB š %z06??P:<+®%C'ID&0'o'ID&%M.6:<+MK%*)Ö3L^g3/5 5:/))@%*.&5%6?}^I3G=7=3 š ?Ò0C¬ 3G,?_?3&.&,0 .d=70 š 'ID&0'q5 0*.hK<% 0Q&Q&)3RZ/,+®0'(% $hK&fÌ0C.R3L)(+z0 =$&,?P'I),KA:&'(,3&.l.

(63)  

(64)  "!. +* $, -. *,+ N+ -. /. w"0. w5opsrDt 0 n uxw4 w u & n/1krN5 ~ u 7}98. 0 w 5rzn. e woux}?e'. :<. 0. ™ D&%)( :=7=K<0 5*œ/©+*Ó% ,·K<=7%*)z0A?f&+®+®%'I),51$L,;<%*)F/%./5 %J+2%06?I:/)%JT-,I? /VB}3&)M)%*=0',;/%1% .6'I)(3&QAf&B}+®0*œ%?2,"' Q/3??,K/=7%±'(3d0*.R0 =Wf >%C'ID&%¼0 +2,.&3U0 5 ,7$2,W./^I3&)ä+Ì0',;/,"'Ifk3L^›'IDR%M5 % .6'I)@0>=/)%6?,7$6:<%M,.d% 05 Dd?P'I)P:<5':/)0*=<5>=70A??. 0. T.( :<==K<0 5*œ®0 .&$/*Ó% ,K=7%*)@B²¸âG§¸Vl ™ D&%0,I? z;/0 =":<%A? š %*)% 5 3&+MQA:&'(% $z0*=·3L.bFÌ'IDR%jiÜ?,Ë'(%6?8. GIH J < F ; N OL M K. =. 89 A1= E A =. :. C. < D. => ;@? 567. E. < D C. < D. E. ;. B. ?. 4 ; 3. T¤AV 2. ?,"'(%;eBg0*.&$. $&%*.R3R'(%?j'IDR%2^)% 96:<% .&5*f]3G^i'IDR%d0>+z,.&3]0 5 ,7$ Â^I3L)¼02F/,;/% .Õß¼¬,. ?. S T Q R P. ,?°'IDR%. 0. )%*^(%*)% .R5 %C^)@% 96:<% ./5f-3L^'ID&% 0 +®,W.R320 5 ,7$ z,W.M'IDR% $&0'(0K/0 .bœl ™ D&%°)% =70'(,;/% % .6'I)3&QAfU, ? <Tfe[V•+®% 0?P:/)%A? W V. 'ID&%H$&,;/%*)(F/%>.R5 %XK/%' š % % .E'ID&%H0 +®,W.R3O0 5 ,7$ž$L,?I'I),KA:&'I,3G./?. Y X l ™ D&%XD&,FGDR%*)2'ID&%X)@%>=70'(,;/%. 0*.R$. %*.'I)3LQAfÌ,e?@B6'ID&% +z3&)%°,.&^I3L)+®0'I,;<%j'ID&%h?,"'(%°,?@BG,.h'(%*)+d?g3&^q0>+z,.&3®0 5 ,7$l. Z\[^]@_a`cbed-fgihdjkilmknIoqp risp lh pt_eoqd-fqs

(65) hdsfp uipvwpl

(66) uipl

(67) hjpxoyhkizIz{kil{dkcv0fqkidkid |vwptos}iop do ™ D&%¼QA:/)Q/3˜?@%M3G^g5 0 .R3L.&,750 =›53L))@%*=70'I,3&.Õ,?i'(3U%ZA'I)05['Ó?%*),%A?}3/^oQ0 ,)?}3/^g5 3L)()% =0'(% $d^I0 5'(3&)?}T w l }AlËB =,./% 0)}5 3G+MK/,./0'(,3L.U3&^•;L0*),0*K/=7%6?(VÖK<%' š % %.-' š 3Ð?@%'?}3&^•;/0)ä,70*K/=7%6?l/è=,./%60)}5 3G+MK/,./0'(,3L.k3G^Ó0k?@%' 3&^›3&),F/,./0 =G;/0*),70*K/=7%6?g,e?Ó5 0 =7=%$-0 50>.R3L.&,750 =L;<0)ä,·0K/=7%Al ™ DR% 3RK~_% 5'(,;/% 3&^'ID&%¼0>.R0 =Wf?,?g,?o'(3Ì^I,./$zT@,^o,"' %Z/,?P'?(V°'ID&%2)% =0',3&.G?D&,Q1K/%' š % %*.1$&,?P'I),Kb:&',3&.13G^Ò0*+®,.&3X05>,7$10*.R$ÐQ&)@3R'e36'fAQ/%?læ.13A:/)M?e':<$6fRB›'ID&%. 3. ;/0)ä,70*K/=7%Ì?@%'?Ó0*)%°'ID&3?%¼$&%6?5),K/,W.&Fk3L.M'IDR%h3&.&% D&0 .&$&BA'ID&%¼=3G50>=?P'I)I:<5':/)% T Ó©ä?@5 3A)%6?Ó3&^

(68) 'IDR% ¸¤M¬

(69) ¯¼?

(70) 8. 3. U€ e TAVVg0*.R$M3&.h'ID&% 36'IDR%*)oD&0 .&$&BA'ID&% 0 +z,.&3®0 5 ,$2?@% 96:%.&5% T Ó©ä?@5 3L)@%6?g3&^˜'IDR%°´/µz0>+z,.&3®0 5 ,7$G?8 . e oT n/VV. 06?_?3/5>,·0'(% $2'I32'ID&% ic?I'I)P:<5[':/)@0*=q5>=70A??@%A?Ò3L^o'ID&%hß¼¬3žl ™ DR%z5 0 .&3&.&,50>= 5 3&))%*=70'I,3&.Â0>.R0 =Wf?,?Ò0 ,+d?±0' ^,./$&,W.bF2'ID&%M+®0*Z/,+®0 =›53L))@%*=70'I,3&.2K/%' š % % .d0M=,./%60)}5 3&+ÌK/,./0'(,3&.d3&^›'ID&%M^,)?I'}?%'²3L^›;L0*),0*K/=7%A?}0 .&$ 0h=,./% 0*)Ó5 3G+MK/,./0'(,3L.®3G^'ID&%-?@% 5 3&.&$d?_%'g3&^

(71) ;<0*),0*K/=7%A?l ™ D&%¼5 0 .&3&.&,50>=q?_5 3L)@%6?Ó0*)%°'ID&%°;/0 =:%6?Ó3G^'ID&% ' š 3z5 0*.R3L.&,75 0 =G;L0*),0*K/=%A?g^I3&)g0°F&,·;L% .hßh¬ã?,Ë'(%  el . ‡ ‹ Ž †. =. ‰‚= ‰. ƒ„. =. α‹ . ‡ Œ. ‡ . †@ˆ Š. Œ †. 0*.R$. . ” ™ œ “. =. —= —. ‘’. =. ‘. β™. ” š. › • ” “@– ˜. š “. žŸ¡ . #%$.

(72)  

(73)  "!. %'&)($*(,+.*. /PFQ9 ^ ;(. ?. &)(. ;H\. [NDo95p. 8 1$359>3)DS81. ( 4. H. (. FD3. **d($H. 89. **( H. 8 9. 4. *. ž1. ( C % ( ( ? 3. 1?:D9)3iL. +,-. -BZ. 1 354j6. ( \ α- ž0b  M13)4 β- ž:c¡ M1 *d( 4 ( ? $( * C J D3 4_L ($=N(. 13)4k1 3lD3N4. 3)4. (. (m%. 3)8. D"?. & ?. &)(. *n;. FQ18?09. - ]srt&5( - A & & *:*( H ( %@( ( + ; &)( B ? E 1 3   8 9 1?:D9)3uL ? 3 ž0/q v1 3)4w6 ž0/ vD ? ?. HS(<;;. 1$3Bq. Z)xyz y{}|.-v~. 1?:D9)3. H\; ; Z &)( ( ( ; D ? 8 9 FaFDS8 D 3<?. 1?:D9)3`1 351. **d($H. 89. &)( -BA C & = * **($H ( H ( * ; &)(M; ( ? 1ED 9>FG8 9 1? 4 DI3 1 89KJMLNDI3N1?D9)3 D3O? D"?. 9>354@?09@?. &)(VUWX;($* Y ( ;Z)*(<;:=N( ( H\] D 8?QD[. 1 3)4T?. H H. ??QD3Yef1gJR1$hNDJR1. =)*(. ;. 81$3)9)3)DS8<1. *:*(<;=. ž/ 28 9. 1$JCD3)9R1 8 DS4. &5(. 3_?. -. ž0/ 21$35476. *:* , + -<Z - ]r&)(€=N($* ( ( K = H ( * ( ; ( \ &N( ž 6   8 < 3 ?G9)F h 1 D3 4T[1 D1 3N8 D eKD[ 3ML ?. 89. H ( &5( H **(H ; ƒ * ( ZE| †„ ] [N1 p 9)F‚? 8 1 3)9)3)DS8 1 8 9 1?:D9>3 p 1 4  ‡. H. 81E359>3)DS8 1. F:1 8?:9. *ˆH. ;. 9N1 4)D3Ye‰D. ?. &)(. * HS( ZMxyz ySZ * * + ZTŒs * [N1 SD 1$L 8$9 ž ž0/q  žbi   9 H. ;. 9N1 4)DI3)e. *. D3`9. 4. ($*. ($*=)*(. ?Q9wDI3?. &)(. ?,?. **. 8 9 (. J. **( H. 8 9. -. ž6. ž0/ . ZTŒ.Ž . 1 3)D3)e9KF,?. &)(. žc¡   . ]€i(. 8 13)9)3)D81. 1 8. &. — ]™˜]>i( 9)F‚? * 9. ])r&)($\. 1 JCDI359•1 8 DS4OqNDI354. &5(T;ƒ. DeNDI3N1. 3<pJML. =. 8 9>J. H. *d(. p1. *(M;. DIeN3)DFDS81$3<?–DF

(74) ?. &5($\ 1. ( H ; &)( H H \ p)? ˆ 4 1 7 9 ? 8 1 359>3)DS8 1 89KJCJ@p3)1 D"? H. 4C8 1$3)9)3)DS8 1. * HS(š›; [>1 D 1$L. ($*. 1. * ( [N1 SD 1 3)8. 9>F8 1 3)9)3)D81. H. 8 9. *H. F:1 8?:9. *:*($H. 9N1 4)DI3Be. ;*($=)* D. 1?:D9)3. ; L. ;. *. FQ9. 9N4<p8 DL. 1€e)D[ H(. *( e (. 89. 1?. ?. *. 1 3X9. 8 1 3)9)3)D81. H. H. DeND3N1 *. F18?:9. * HS(<; *d(EH ( &)( * H [>1 D 1$L 1?:D[ ?:9ˆ? 9 DeND3N1 ?. (*. ( &)( p)? i 4 ?. &N(u;. DeK3)DSFDS8 1 3)8. (. 9)F. (. 1 8. &wU

(75) W. 1E3N4. & ( = * H ( ? $ 1 3R1E3 J D DS8 1 8p)?:9>FQFFaDh 4R1?. ( %'& & **(;= ; &)(7; FQFaDS8<D < 3 ? D8 8 9 9)3)4 ?Q97? pJ. * HS(Y] ^ ( ; *(Y;& % 3M[N1 oD 1L ?sJ 1 p 9 (. * F > 9 J. ( @ % ( ( % ? 3u? 9. *(. * HS(`% & [>1 SD 1L D"? =. 8 9KJ. H. * HS(<;]’‘ *'( &“; * * H H ;”;n(<;dZ &)(ŠH ;O;:=N( \ [N1 SD 1$L 9 1 8 ?  p 8?p 1 8 1 ? 9K14>D3)e 8EDF (. H. 1?:D9)3j9NFŠ1‹8 1 359>3)DS81. &5(. 8 1 3)9)3)DS8 1. H. &. JTp8. * HS(5;œ]Crt&5( [1 D 1$L. (. 9)Fs1€eKD[. 3. JC1$hNDJMpJ. ;( ; * HS(5; ;MH ( &5( (* ? 9>F.[N1 DS1$L D DJRD"? 4_?09_? 3pJML 9KF. ^ & * HS(<; * &5(T; HHS(<; d; ( ZYxyzy{”žŸv&)($*(B]E ¡= (V% ; d; ( ( H ( Ztž£)£)Ÿ ] [N1 SD 1$L FQ9 ? JC1 ? ? 1 8$qN1$e 1 p 4 ž 1$qN1 1$3)4C¢ 3<? 7 J 1 3  . ¤¥’¦_§K¨ ©–ªa«œ¨ ¬B­®Y¯°P±I²)³œ´Y³µŠ¶·•¶)¸ ¹$³œº´»)»,±S¼>½•¾œ¿I³ÀÁ ¿SÀ³´)ºN•¶)¿± ·K¾ r&)(`H. DL. * * \ 1. H ;”;d(5;œ]€É & 8 1 1 8. * ( * ( $ \ 1  1 8? D à 4‹L. H ;; 8 1. * ( ; žaF 1 eKJ 3<?. 9KF. *($=)*d(<;(. (. 3?:1?QD[. & 8. Ÿ 9)F€?. ;. H (<; D3N8  p 4 p8 8. (Y;”;. &)(u=)*. D[. ( 9<? D 3. ?. &)(. FQD3N1. H€ÄvUÅ. * ( ;`;:& * F $ 1 eNJ 3<? 1 D3)e. (ËUWv; H. 9K81. H. 8 9. *:*(<;=. ; D ;. 89)J. = 9. ;(. 4Æ9)F. žÇ —. 9Y[. (*ÈH ) = = 1 D3)e. ; * * H ? p8œ?p 1. H *wH H•; * *(<;_( ( DIJRD 1 9N8 1 ?  p 8?p 3)8 9N4 4ÊD3<?:9. 9)3)4YD3BeÌ?09. ž)ž. H ; ;($* ( &5( FQ9 4 9YL [ 4“D3m?. 1 JCD3)9Í1<8 D4 4)1?:1LN1 3Yq. ; ˆ ] r&)(Y;d(  . ]–£YÎ]}Ç)Ï. 9)F€?. H ;n;(Y; 8 1 &)(. UWv; 1. *n(. * ( ; F $ 1 eNJ 3?. #$#.

(76)  

(77)  "!. * &5( * d; ( %C($*d( H ( &)(VÄvU’Å F K 9 Jj? ? 1 D3)DI3)e ? D3Y[N9 [ 4OD3M? *(. %. JC1 D3KD3)e. *($=)*d(<;( ‡. ; 1. ; * ( ( &5( * H %ÍH ;v; *(<; ;d( (ˆ; =)=NHS( ( *d\ 4)D. 8 1 4 4u4<p ?:9 ? D 9 9>e_9K4)4 8 9 ž p J 3<?:1. &)(€H(Y;”;. 3??. F. *(ƒ. H\; ; &)( D 9KF€?. 3)1. * Z>x:]›z5]"ZN£)£YZÇžΕ; * * H * ( ;œ]Yr&)( ? 1 D3ND3)e ?  p 8”?p 1 F 1eKJ 3<?. ( p. (. HS(<;. 3)1$L. H. ?:9. 9K8 1?. (ˆ*(. ;. eBD9K3. *(. 9)F. H *7;( *\¡; * *( eYp 1 89>354K1 ?  p 8?p. &)( . * =)*( ($*d( H * ; ;œ]>‘ *(C˜ ;& %R; &)( * UW D F 3?Do1 ? 1$3 D"?Do9>3 DeYp 1 9 ? JR1? D"h 9KF ?. =)*. = 9. & 8. * H 9 Q? D9)3)1. UW. ?:9. *( ƒ F. ]r&)( \  . ;($* Y ( ; U

(78) Wv;œ] D 9)F. 3?. HVÄvUÅ. FaD3N1. Ç. 4)1?:1. p. (. 358ED. (<;œ]ur&)(ËÄM\. * L. UG*. DS4. ( 9<? D 3. Å. 1$3N4. ; * ;,% & * \ HS( ( Ha; 4)D ? DLYp)?:D9)3 D"? e 1 [ ( H. 9N4. (; * ( 8 DL 4 4. &N($*(. HIH R % ; 9 1. ?. &)(. * ( * ; * * H)=)* \B=N(5;G*($=)*(<;d( ( &)( H HK=)* ( * ( ; ;d($* ( 1. 1 8? D Ã1?:D9>3@9>F ? p8”?p 1 9<?09<? 3<?:1?QD[ 9)F? 9N8 1 9<? DI3CF 1eKJ 3<? 9YL [ 4 &)(. D3j?. ]€É. 4)1?:1L>1 3Yq. * ( ;] F $ 1 eNJ 3<? 9. (. &. 1 8. &. 18. ; * * H H ;n; ? p8?p 1 8 1. 9KF•?. &)(ÆH. * d* \ 1. DL. H ;; (u*(=)*(<;n( ( \ 8 1 8 1 3‹L 3<? 4`L ?. ; D. &)(u=)*. =. 8 9NJ. ( 9<? D 3. ;d( 9. ; * * HH\ ? p8?p 1. 4Ê9)F. ;. H * DIJRD 1. * ( ; * *(Z ( ( ; F 1 eKJ 3<? ? p8”?p 4 FQDI3 4‹1. ; * * HK=)* \B=N( Z &)( H ;(<; &5( ( * $ (vH H H ]<‘ *d( Î ; =)=NHS( ( *d\ ˜ ? p8œ?p 1 9<?09<? ? 8 9 ?

(79) ?09@? 1[ 1 e $ 9K81 FQ9 4 DIeYp ž1$3)4 p J 3<?:1 4)1?:1   ;& 9Y[. %R; 9. & * &)(Æ; * * H =)* \B=N(<; ? D 4k9KFM? ?  p 8?p 1 95?09<?. 9>F7?. &5(gH. * * \ 1. DL. Ä ž. =K&B*($\f(. pJ. ? 1. H ]"Z•ž£)£)Ÿ. ]Prt&5(  . ($*H = ; *(<; ; * * H \'* ( ( %C(( &)(T; (<;; (T; * * H H ;”;d(5;dZ * ( &)(Y; 1 D3 p 1 ? p8?p 1 8 9)3<?:DI3pD™? 1? L ? 3M? p88 D[ ?  p 8”?p 1 8 1 D"? 1 8  — ϓ]<Å. Ÿ. (. 9)3. *( 9. ($*dZ 5 & ( H (<; = ( H &)(€ÄvU

(80) Å ? /ˆ[>1 p 8 9KJ p)? 471 9)3Ye7?. 9Y[. ; * * H ; H \]2r &)( ? p8œ?p 1 ?:1LND D"? ;].r&)(. 1 JCDI359k1 8 D4. (*. 1$[. (  . 1$e. H ( /Æ[N1 p. H ; ($*”; ( *d( 8 p ? 95LB?:1 DI3 4Æ1. žB]"£YÎ

(81) . 9>F. *2(. D. FQ9 ;C*. 1?. 1 8. &C=)*. &5($*•;. JC1. H HSHI\k& ( ( ;Š; ( e > 9 LN1 9KJC9)e 3 9Yp DI3N8. \B=N(. 9Y?Q9<? HH ?. FQ9. *. D3N4)D81?. (. & 1. &. DIe. * ( ; ž)ž F 1 eKJ 3<? 9)F. &)( . H (<; *\ / k[>1 p [N1. & &)(T* ( — ]™˜ ˜]"˜’ž n])rt&N(vH %@(Y; H ( ; ( * &)(C; ()ÇNŸ ”; ; ( D"? D 3C? 1 3Be 9 ?s[N1 p D 9YLY?:1 D3 47FQ9 ? D"? 1 N 9 8 DS1? 4@?09•1 % H. 9K3Be. A α 5& (EH Dh. 1 3)4l?. &5(. H. J71$hNDSJ71. H ( [1 p. FQ9. *. &)(l; ?. D™?. (Ç. 89. **d(<;=. 9)3)4)D3Yej?:9‰1. *(. e)D9)3. %O(. 1$q. H\. ; * * ( ] ? p8œ?p 4 r&)(. H\; ; &)(_ÄvUÅ D 9)F ?. NrG  ^. 1 3)1 É ž. 1 8 8 9. *. 4)D3Ye“?:9. ?. &5( ?. &B*( (`;. ?:1”?. (<;•;d(. ‡ * ‘* ; & ;Zž£)£ Z‚;:& %7; & &)(VUWM; D JR1 3R1E354 eN9   9 ? 1??. 8 9)3)4)1. *\k; * *( ? p8?p =)=)*. 1 3)4  1. 9YhNDJR1?. (V%. ;n; 1. D"?. &. DeK3. (. 1 8 8p. \. 4gL *. \. 18. A A α )& ( H DS8 (<; 1E354 β ; ? * 1$3)4 ;–*(Y;:=N( 8?:Do[ ( HI\5Z 1E354@? & 1?’? &5( [N1 * DS1$LND H D"? \ 9KF? &)( 89KD H’; ?:1? ( D ; e H 9>L>1 HSHI\ ?:1$q ( 3 D3<?:9“1 88 95pN3?.L. \. &)( ?. 9<?. &)($* UWv;]r&Y*((. * HS( H ( & * [N1 SD 1$L D3 3 eY? ždF 9KJ B ÇN£"ZSΞ A Î#aZ$Ÿ * žaF N 9 J. ˜. ?09. Ÿ. Ÿ. A Ÿ. UWv;€H. — . Î. ?09. 1$3)4•1. 9)3Yei 8. &. *d(TH. £7UWT; 1$L. ( H( 4.  P1. ? *(. \Y=N(Y;. 9)F. A α 5& ( H Dh 8 & 1 * 1 8? $( * D à ( 4_L \ ;n($* D (Y; 9>F UW!. ; ;& HS(Y]r&)($\ 4YD :? D3YeYpD 1$L 1. *(CH. α žZ αÇ 1$3)4 α˜)Z*(<;=N( 8?QD[ ( HI\‚]. * ( * ( $ \`;n($* (Y; UW 1  1 8? D à 4•L D 9>F. 1. *d(. . 1$3)4. ( &)(M*( ;Çž A 9N8 1? • 4 D37? eND9)3 DIFQF. ($*(. 3<??. \B=N(<;. ; ;& HS(@% & 4YD ? D3YeYpD 1$L D™? 1. 9>F. A β ; ? * 1$3)4. ; * UW ? 9)3Ye. #.

(82)  

(83)  "!. ;. *(Y]$. DeN3N1?p A ˜. ˜. A ž)ž. ”ž)žŸ. 1$354. A β ; ? * 1$354 ; 1 *d(@%@(EHH 4 ( H SD J7D"? ( 4 Z’x]}z)]}Z ? & 9 ;(OH 9K8 1? ( 4ˆD3 ? &5(O*( eKD9N3 ;. &)(. 9KF–?. ”]vr&)(. Ÿ. * D3<? N 9 4<p8”?QD9>3. 4)DFF. U

(84) W. 9)F. (*(. A β ; ? * 1$354 ; 1 *(ÆH 1$L ( H( 4. 3<?. ;d($* < ( ; UW D 9>F. D3. HS( . ;. 1 4. ( C % ( ( &5(<;(u*( H *•; * * H.*( ; *( ? 3`? eYp 1 ?  p 8”?p 1 eKD9N3 1 L. *( ž. ˜. e)D9>3. AÎ —  Ÿ. Î. (.  v4. (;. FQDI3. ⠞ ?09 ⠟Ê1 H 9)3Yej? &5(‹ÄTUÅk]vr&)(. ; * ( ?:9“4)D :? 9 ? 4. A β ; ? * 13)4 ;]’Us*( F ($*( 3?D1 H ? * 1$3 ; D"?:D9K3 ;. * ; ( %C(( 1O? $ 1 3 D"?:D9)3uL ? 3w1. ;n($* ( ] ‡ ; [ 4 1 3. **d(<;=. 89. ;(* 5 ( ; - D. HH ; * Z &)(ˆUW D p ? 1?QD9)3 ?. A A β ; ? * 1$354w1$3)4w1 3 α &N( H Dh Z ? &5(OUW. ;($* < ( ;

(85)  D b. A & ( H A ; * Z &)(7;($* (Y;2zNx ; (Y; αN Dh•?:9Š1 β ? 1$354 13)47? D b ž D"?. A β ; ? * 1$354 ;]. * ; ( %@( ( %  M17? 1 3 D"?:D9K3wL ? 3u? 9. A BŸ"QZ B£ A £YÇ QZ”ž)ž)ž A žÇ — ]r&)($\ Ÿ. A ž˜"Z Ÿ. * F ) 9 J. 9YL. ; (; ÇN£ A ˜)˜" & * ( * (5; $ H =ˆH ž "D ?  .8 1 1 8? D à 1 9N9 D3)qKD3Beu1 3 A ”ž — Ç ž — #. . A ž —)— :Z5%'& H ( &5($*”; *( H ( ($**d( ;Z)z)] –]"Z " A Ÿ’ž aZ  — A Ç Z”ž — A ž — £# D 9<? 1 9K8 1? 4OD3CFpNà ÃD e)D9)3 Ÿ. QZ £YÎ. Ÿ. (. 9)J. . %v&. 9)3)4 ?09. (ˆ*(. 9)J. 1?sD. ;. eKD9)3 (. e. 3. ;. 9KFV?. &5( ÄvU

(86) Å 1. *(. ($*Z z5] –]™Z. FpNà ÃD. ($* H HI\ ; ($*( ; HN*( ;] 1 89>3 D4 4O1 8 9)D eND9)3. ¬B­)¯$¼¿I³œ¶)ÀÁ ±¼)½M½´» ¾.±Â.» ³œ¶)¸ ¹$¾.¿

(87) ¹€¾œ¿I³œÀ

(88) Á¿À³´)º» ³œ¶)¿¶)¿ µ»,¹ º±²)³´Y³µ ‘. *(Ƙ. DeYp. ;& L. %7; 9. ?. &)(. ($*. 3pJML. * ( ; 9>FŠF $ 1 eNJ 3?. H ;”;d(5;œ],r&)(“; * * H * ( ; *d(m( ( H\ 8 1 ?  p 8”?p 1 F 1eKJ 3<? 1 [ 3 ;( ;. *\Æ; * *(ˆ*d( ; H *”; ? p8?p e)D9)3 žaL 1 8$q“L1 D3. 8 9>354)1 D"?. (<;vÇž. ÇN£. 1$3)4. 8 9)3<?:1 D3. ;. & 1. &. De. 3pJML. ($*. ;n; 1. ( &)( 9N8 D1? l 4 ?09i?. 4>DFQF. ($*d(. ; * ( H &)(ˆÄvUÅ 4>D ? DLBp)? 4‹1 9)3Ye“? ‘. DIe. ]–˜. ; * * H * ( ; H\ ? p8?p 1 F 1$eKJ 3<? JC1 D3. 9)F. (. hN8. ($=. ; * * H ? p8”?p 1 *O*d(. ?CFQ9. H * eYp 1. A & ( H * ( ( ( ( %@( ( αN Dh e D9K3 N hY? 354>D3)e“L ? 3. ]–rt&5(. L  . ÄTUÅ. 3?. ( 8. 3?. ($*(. ;. 41œ?. D"?. ( )Ç)Î. ž˜)Z £ — * ( ; ])r&)(TH %@(Y; ($*n; * ( ; *( ”; ; ( H*( ;Z>% &ˆ; ( Ÿ F 1$eKJ 3<?   9 ?3pJML 9NFF 1eKJ 3<? 1 1 K 9 8 DS1? 4M?Q9•89>D eKD9N3 D™? D"? ž. &)(wH( ? ;. ; = = H ( 1 ? 9 p 1? 4. *(;Z. 89. ÄvU

Références

Télécharger maintenant ( PDF - 32 Page - 610.92 KB )

Documents relatifs

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport.

To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed

Valorisation des boues de désencrage : production et purification de l'acide lactique

Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à

ATAXIE SPINOCÉRÉBELLEUSE ET POLYNEUROPATHIE AXONALE CAUSÉES PAR UNE MUTATION DU GÈNE MME : CAS CLINIQUE

Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine

Atelier 2 : Hyperpaysages

En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages

Utilisation du cadre théorique de la planification pour la conception d'algorithmes complexes par des élèves de lycée

Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur

Time-varying respiratory system elastance: a physiological model for patients who are spontaneously breathing.

A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated

TIMELY FUNGICIDE APPLICATION: A STRATEGY TO MINIMIZE FUSARIUM HEAD BLIGHT AND ASSOCIATED MYCOTOXIN PRODUCTION IN WINTER WHEAT

The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide

'Nature never did betray / The heart that loved her' : l'éthique du retour à la nature dans l’œuvre de Mary Shelley

Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to