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Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process

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Academic year: 2021

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Fig. 2 Impact of AMPK hyper-activation on synaptic markers expression. Primary neurons were treated at 20 DIV for the indicated times with the AMPK activator, AICAR (1 mM)
Fig. 3 Effect of AMPK hyper-activation on synaptic density. AMPK hyper-activation was induced in primary neurons using AICAR (1 mM) at 20 DIV for the indicated times
Fig. 5 Involvement of autophagy in post-synaptic markers degradation. Neurons were treated with AICAR (1 mM) at 20 DIV for the indicated times
Fig. 7 Impact of AMPK hyper-activation on synaptic markers in vivo in mice. Two-month-old WT mice were injected with lentiviral vectors (LV) to allow the expression of the CA-AMPK in the hippocampus

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