PLAN OF THE THESIS I. General introduction

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I. General introduction

PART ONE

Ambulatory diagnostic tools for sleep disordered breathing assessment

I. Introduction

1.Introduction to sleep disorders 1.1 Epidemiology

1.2 Classification

2. Obstructive sleep apnea syndrome and sleep disordered breathing 2.1 Definition

2.2 Epidemiology and risk factors 2.3 Pathophysiologic consequences

2.4 Health-related morbidity and mortality

3. Ambulatory diagnostic tools for sleep disordered breathing assessment

3.1Introduction and Gold Standard 3.2Home sleep testing

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III. Personal contributions:

 First work: study comparing unattended home-based polysomnography and in-lab polysomnography

 Second work: Review of the literature

 Third work: study on hook-up location for home-based unattended polysomnography

 Forth work: the « Sleepbox » Study

 Fifth work: Screening for sleep disordered breathing in acute coronary syndrome

PART TWO

Monitoring techniques to assess impact of treatment on clinical outcomes in sleep disordered breathing

I. Introduction

1. Treatment of sleep disordered breathing 1.1 Introduction

1.2 Positive airway pressure treatment

1.3 Monitoring the impact of treatment on clinical outcomes of sleep disordered breathing

1.3.1Assessment of treatment effectiveness

1.3.2Assessment of objective compliance to CPAP treatment

1.3.3Assessment of improvement of daytime and night time symptoms

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II. Aim of the thesis

III. Personal contributions:

 First work: Physical activity and quality of life in obstructive sleep apnea patients

 Second work: Changes in sleep patterns in treated patients with OSA

DISCUSSION AND PERSPECTIVES I. Introduction

1. Home unattended polysomnography

2. Ambulatory assessment of the impact of SDB treatment on clinical outcomes

II. Clinical implications III.Managerial implications IV.Discussion

2. Ambulatory assessment of the impact of SDB treatment on clinical outcomes

V.Conclusion

VI.Futures directions

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