• Aucun résultat trouvé

Genistein induces pancreatic β-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice

N/A
N/A
Protected

Academic year: 2021

Partager "Genistein induces pancreatic β-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice"

Copied!
13
0
0

Texte intégral

Loading

Figure

FIG. 1. Genistein (Gen) stimulates proliferation of ␤-cells. A, INS1 cells were incubated with various concentrations of Gen or vehicle in RPMI 1640 medium for 24 h, followed by addition of BrdU (10 ␮ M ) for 4 h
FIG. 3. Genistein (G)-induced ␤-cell proliferation is ER independent. A, INS1 cells were preincubated with ICI (I; 2 ␮ M ) or vehicle for 30 min, followed by addition of G (1 ␮ M ) or vehicle (C)
FIG. 5. Genistein (Gen) stimulates intracellular cAMP accumulation, activates PKA and ERK1/2, and subsequently stimulates cell
FIG. 7. Genistein (Gen) has no effect on plasma lipid profiles and hepatic antioxidant enzyme activities in STZ-induced diabetic mice.
+2

Références

Documents relatifs

Treatment satisfaction and quality of life using an early insulinization strategy with insulin glargine compared to an adjusted oral therapy in the management of Type 2 diabetes:

They also inhibited suppression of STZ-induced insuli- noma cell death by DPQ (Fig. 4b, bars 6–9 from the left for okadaic acid and vanadate), supporting that inhibition of

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des

Ainsi, on s’attend, pour l’ensemble de la Suisse, à une proportion accrue de séniors vivant également de plus en plus longtemps, avec des besoins d’aide et de soins

To examine if undifferentiated MDSC could differentiate in vivo into functional beta cells, MDSC were isolated from a donor mouse expressing mCherry under the control of the rat

Plasma insulin levels, determined at baseline, 15 and 90 min following glucose load were similar in mice treated by 1 versus control vehicle, suggesting that the impaired

In almost all data, Aloe QDM has been demonstrated to significantly improve insulin resistance and suppresse mRNA expression of proinflammatory cytokines in WAT

With the aim to develop a regionalization procedure for the parameters, based on the identification of homogeneous ar- eas with respect to the basic component of the rainfall