Voltage-gated sodium channels from the bees Apis mellifera and Bombus terrestris are differentially modulated by pyrethroid insecticides

In addition we also reported drug-induced use-dependent modifications of current peak and current tail, that have previously been proposed to result from (i) accumulation

In conclusion, our work demonstrates for the first time that density, gating and pharmacological properties of Na v channels expressed in Xenopus oocytes can be modulated by an

When tracking the conformational rearrangements of the voltage sensor experimentally, one usually measures a gating charge transferred across the membrane (see

We used 3794 variants in the Genome Aggregation Database (gnomAD) (Karczewski et al., 2019) as variants with inferred neutral effects (see Table S2) during training of

Hypoxic Condi- tions Promote Rhythmic Contractile Oscillations Mediated by Voltage-Gated Sodium Channels Acti- vation in

We demonstrate with functional studies using the patch clamp technique that the sodium currents observed in the cancerous H23, H460 and Calu-1 cells are due to

The aim of this review is to describe the current knowledge on the functional expression of voltage-gated sodium channels and their biological roles in different cancers such as

Cancer Cell Colony Growth and Three-dimensional Matrix Inva- sion—As we have previously re- ported, sodium channels promote cell invasion but do not participate in in