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A long-lasting calcium-activated nonselective cationic current is generated by synaptic stimulation or exogenous activation of group I metabotropic glutamate receptors in CA1 pyramidal neurons.

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Academic year: 2021

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Figure 2. I AC PD is associated with an increase in intracellular [Ca 21 ].
Figure 6. I CAN induced by 1S,3R-ACPD is not regulated by forskolin, an activator of adenylyl cyclase, and also can be induced by carbachol, a selective agonist of muscarinic receptors
Figure 7. The divalent cation magnesium induces a voltage-dependent block, whereas divalent cations cadmium and zinc induce a voltage-independent block of CAN currents produced by 1S,3R-ACPD

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